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  • 1
    Publication Date: 2009-11-11
    Description: Deprotonation of alkyl and vinyl carbon-hydrogen bonds for synthetic purposes is often hindered not merely by the need for an exceptionally strong base, but by the inherent instability of the resultant anion. Metalation of cyclic ethers adjacent to oxygen, for example, has invariably initiated a ring-opening decomposition pathway. Here, we show that the use of a bimetallic base can overcome such instability through a cooperative combination of zinc-carbon and sodium-oxygen bonding. Both tetrahydrofuran and tetrahydropyran reacted cleanly over days at room temperature to yield alpha-zinc-substituted products that were sufficiently stable to be isolated and crystallographically characterized. A related zincation-anion trapping strategy, with sodium replaced by potassium, induced clean deprotonation of ethene to yield a stable product. Preliminary electrophilic quenching experiments with the alpha-zinc-substituted cyclic ethers and benzoyl chloride gave satisfactory yields of the tetrahydrofuran-derived ketone but only trace amounts of the tetrahydropyran-derived ketone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Alan R -- Klett, Jan -- Mulvey, Robert E -- Wright, Dominic S -- New York, N.Y. -- Science. 2009 Oct 30;326(5953):706-8. doi: 10.1126/science.1178165.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900927" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-11-15
    Description: The regioselectivity of deprotonation reactions between arene substrates and basic metalating agents is usually governed by the electronic and/or coordinative characteristics of a directing group attached to the benzene ring. Generally, the reaction takes place in the ortho position, adjacent to the substituent. Here, we introduce a protocol by which the metalating agent, a disodium-monomagnesium alkyl-amide, forms a template that extends regioselectivity to more distant arene sites. Depending on the nature of the directing group, ortho-meta' or meta-meta' dimetalation is observed, in the latter case breaking the dogma of ortho metalation. This concept is elaborated through the characterization of both organometallic intermediates and electrophilically quenched products.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez-Martinez, Antonio J -- Kennedy, Alan R -- Mulvey, Robert E -- O'Hara, Charles T -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):834-7. doi: 10.1126/science.1259662.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. ; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. r.e.mulvey@strath.ac.uk charlie.ohara@strath.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395533" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2014-07-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazer, David -- Kennedy, Ryan -- King, Gary -- Vespignani, Alessandro -- New York, N.Y. -- Science. 2014 Jul 11;345(6193):148-9. doi: 10.1126/science.345.6193.148-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lazer Laboratory, Northeastern University, Boston, MA 02115, USA. Harvard Kennedy School, Harvard University, Cambridge, MA 02138, USA. d.lazer@neu.edu. ; Lazer Laboratory, Northeastern University, Boston, MA 02115, USA. Institute for Quantitative Social Science, Harvard University, Cambridge, MA 02138, USA. University of Houston, Houston, TX 77204, USA. ; Institute for Quantitative Social Science, Harvard University, Cambridge, MA 02138, USA. ; Laboratory for the Modeling of Biological and Sociotechnical Systems, Northeastern University, Boston, MA 02115, USA. Institute for Scientific Interchange Foundation, Turin, Italy. Institute for Quantitative Social Science, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25013053" target="_blank"〉PubMed〈/a〉
    Keywords: *Disease Outbreaks ; Humans ; Influenza, Human/*epidemiology ; Office Visits/*trends ; Social Media/*utilization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazer, David -- Kennedy, Ryan -- King, Gary -- Vespignani, Alessandro -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1203-5. doi: 10.1126/science.1248506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lazer Laboratory, Northeastern University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626916" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.) ; Data Collection/statistics & numerical data ; Data Interpretation, Statistical ; *Disease Outbreaks ; Humans ; Influenza, Human/*epidemiology ; Office Visits/statistics & numerical data/*trends ; Prognosis ; Social Media/*utilization ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1996-05-31
    Description: Helioseismology requires nearly continuous observations of the oscillations of the solar surface for long periods of time in order to obtain precise measurements of the sun's normal modes of oscillation. The GONG project acquires velocity images from a network of six identical instruments distributed around the world. The GONG network began full operation in October 1995. It has achieved a duty cycle of 89 percent and reduced the magnitude of spectral artifacts by a factor of 280 in power, compared with single-site observations. The instrumental noise is less than the observed solar background.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey -- Hill -- Hubbard -- Kennedy -- Leibacher -- Pintar -- Gilman -- Noyes -- Title -- Toomre -- Ulrich -- Bhatnagar -- Kennewell -- Marquette -- Patron -- Saa -- Yasukawa -- New York, N.Y. -- Science. 1996 May 31;272(5266):1284-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. W. Harvey, F. Hill, R. P. Hubbard, J. R. Kennedy, J. W. Leibacher, and J. A. Pintar are with the National Solar Observatory, National Optical Astronomy Observatories, Post Office Box 26732, Tucson, AZ 85726-6732, USA. P. A. Gilman is with the High Altitude Observatory, National Center for Atmospheric Research, Post Office Box 3000, Boulder, CO 80307, USA. R. W. Noyes is with the Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138, USA. A. M. Title is with the Lockheed Solar and Astrophysics Laboratory, Palo Alto, CA 94304, USA. J. Toomre is with JILA, University of Colorado, Boulder, CO 80309, USA. R. K. Ulrich is with the Department of Physics and Astronomy, University of California, Los Angeles, CA 90024, USA. A. Bhatnagar is with the Udaipur Solar Observatory, Physical Research Laboratory, Udaipur, India. J. A. Kennewell is with the Learmonth Solar Observatory, IPS Radio and Space Services, Exmouth, Western Australia, Australia. W. Marquette is with the Big Bear Solar Observatory, Big Bear City, CA 92314, and California Institute of Technology, 264-33, Pasadena, CA 91125, USA. J. Patron is with the Observatorio del Teide, Instituto Astrofisica de Canarias, La Laguna, Tenerife, Spain. O. Saa is with the Cerro Tololo Interamerican Observatory, National Optical Astronomy Observatories, La Serena, Chile. E. Yasukawa is with the Mauna Loa Solar Observatory, Hilo, HI 96720, and High Altitude Observatory, National Center for Atmospheric Research, Post Office Box 3000, Boulder, CO 80307, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662455" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1996-05-31
    Description: The Global Oscillation Network Group (GONG) project estimates the frequencies, amplitudes, and linewidths of more than 250,000 acoustic resonances of the sun from data sets lasting 36 days. The frequency resolution of a single data set is 0.321 microhertz. For frequencies averaged over the azimuthal order m, the median formal error is 0.044 microhertz, and the associated median fractional error is 1.6 x 10(-5). For a 3-year data set, the fractional error is expected to be 3 x 10(-6). The GONG m-averaged frequency measurements differ from other helioseismic data sets by 0.03 to 0.08 microhertz. The differences arise from a combination of systematic errors, random errors, and possible changes in solar structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hill -- Stark -- Stebbins -- Anderson -- Antia -- Brown -- Duvall Jr -- Haber -- Harvey -- Hathaway -- Howe -- Hubbard -- Jones -- Kennedy -- Korzennik -- Kosovichev -- Leibacher -- Libbrecht -- Pintar -- Rhodes Jr -- Schou -- Thompson -- Tomczyk -- Toner -- Toussaint -- Williams -- New York, N.Y. -- Science. 1996 May 31;272(5266):1292-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉F. Hill, E. R. Anderson, J. W. Harvey, R. P. Hubbard, J. R. Kennedy, J. W. Leibacher, J. A. Pintar, C. G. Toner, R. Toussaint, and W. E. Williams are with the National Solar Observatory, National Optical Astronomy Observatories (NOAO), Post Office Box 26732, Tucson, AZ 85726-6732, USA. P. B. Stark is with the Department of Statistics and Space Sciences Laboratory, University of California, Berkeley, CA 94720, USA. R. T. Stebbins and D. A. Haber are with JILA, University of Colorado, Boulder, CO 80309, USA. H. M. Antia is with the Tata Institute of Fundamental Research, Bombay, India. T. M. Brown and S. Tomczyk are with the High Altitude Observatory, National Center for Atmospheric Research, Boulder, CO 80307, USA. T. L. Duvall is with the NASA Goddard Space Flight Center, Stanford University, Center for Space Science and Astrophysics (CSSA), Stanford, CA 94305, USA. D. H. Hathaway is with the NASA Marshall Space Flight Center, Mail Code ES82, Huntsville, AL 35812, USA. R. Howe and M. J. Thompson are with the Astronomy Unit, Queen Mary and Westfield College, London E1 4NS, UK. H. P. Jones is with the NASA Goddard Space Flight Center Southwest Station, NOAO, Tucson, AZ 85726, USA. S. G. Korzennik is with the Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138, USA. A. G. Kosovichev and J. Schou are with Stanford University, CSSA, Stanford, CA 94305, USA. K. G. Libbrecht is with the California Institute of Technology, 264-33, Pasadena, CA 91125, USA. E. J. Rhodes is with the Department of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662457" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2009-09-26
    Description: New impact craters at five sites in the martian mid-latitudes excavated material from depths of decimeters that has a brightness and color indicative of water ice. Near-infrared spectra of the largest example confirm this composition, and repeated imaging showed fading over several months, as expected for sublimating ice. Thermal models of one site show that millimeters of sublimation occurred during this fading period, indicating clean ice rather than ice in soil pores. Our derived ice-table depths are consistent with models using higher long-term average atmospheric water vapor content than present values. Craters at most of these sites may have excavated completely through this clean ice, probing the ice table to previously unsampled depths of meters and revealing substantial heterogeneity in the vertical distribution of the ice itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Byrne, Shane -- Dundas, Colin M -- Kennedy, Megan R -- Mellon, Michael T -- McEwen, Alfred S -- Cull, Selby C -- Daubar, Ingrid J -- Shean, David E -- Seelos, Kimberly D -- Murchie, Scott L -- Cantor, Bruce A -- Arvidson, Raymond E -- Edgett, Kenneth S -- Reufer, Andreas -- Thomas, Nicolas -- Harrison, Tanya N -- Posiolova, Liliya V -- Seelos, Frank P -- New York, N.Y. -- Science. 2009 Sep 25;325(5948):1674-6. doi: 10.1126/science.1175307.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA. shane@lpl.arizona.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19779195" target="_blank"〉PubMed〈/a〉
    Keywords: Extraterrestrial Environment ; *Ice ; *Mars ; Meteoroids ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 1980-03-14
    Description: Fluorescent light induced a dose-dependent malignant transformation in mouse C3H10T1/2 cells. A plateau in the dose-response curve for transformation was correlated with that observed with ultraviolet light exposure. The similarity in the two dose-response patterns suggests that similar molecular processes may be involved in the induction of malignant transformation by the two types of radiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, A R -- Ritter, M A -- Little, J B -- New York, N.Y. -- Science. 1980 Mar 14;207(4436):1209-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355282" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Survival/radiation effects ; Cell Transformation, Neoplastic/*radiation effects ; Cells, Cultured ; DNA/radiation effects ; Dose-Response Relationship, Radiation ; Embryo, Mammalian/radiation effects ; Fluorescence ; *Light ; Mice ; Pyrimidine Dimers/radiation effects ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2018-12-20
    Description: After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorded provenance, making their repatriation very difficult or impossible. To determine whether DNA-based methods could resolve this important problem, we sequenced 10 nuclear genomes and 27 mitogenomes from ancient pre-European Aboriginal Australians (up to 1540 years before the present) of known provenance and compared them to 100 high-coverage contemporary Aboriginal Australian genomes, also of known provenance. We report substantial ancient population structure showing strong genetic affinities between ancient and contemporary Aboriginal Australian individuals from the same geographic location. Our findings demonstrate the feasibility of successfully identifying the origins of unprovenanced ancestral remains using genomic methods.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 10
    Publication Date: 2018
    Description: 〈p〉After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorded provenance, making their repatriation very difficult or impossible. To determine whether DNA-based methods could resolve this important problem, we sequenced 10 nuclear genomes and 27 mitogenomes from ancient pre-European Aboriginal Australians (up to 1540 years before the present) of known provenance and compared them to 100 high-coverage contemporary Aboriginal Australian genomes, also of known provenance. We report substantial ancient population structure showing strong genetic affinities between ancient and contemporary Aboriginal Australian individuals from the same geographic location. Our findings demonstrate the feasibility of successfully identifying the origins of unprovenanced ancestral remains using genomic methods.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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