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  • International Union of Crystallography (IUCr)  (14)
  • American Association for the Advancement of Science (AAAS)  (13)
  • 1
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    Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉The interaction between gastric epithelium and immune response plays key roles in 〈i〉H. pylori〈/i〉–associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in 〈i〉H. pylori〈/i〉 infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by 〈i〉H. pylori〈/i〉 and IL-22 via the ERK pathway. Human gastric MMP-10 was correlated with 〈i〉H. pylori〈/i〉 colonization and the severity of gastritis, and mouse MMP-10 from non–BM-derived cells promoted bacteria colonization and inflammation. 〈i〉H. pylori〈/i〉 colonization and inflammation were attenuated in IL-22〈sup〉–/–〈/sup〉, MMP-10〈sup〉–/–〈/sup〉, and IL-22〈sup〉–/–〈/sup〉MMP-10〈sup〉–/–〈/sup〉 mice. MMP-10–associated inflammation is characterized by the influx of CD8〈sup〉+〈/sup〉 T cells, whose migration is induced via MMP-10–CXCL16 axis by gastric epithelial cells. Under the influence of MMP-10, Reg3a, E-cadherin, and zonula occludens–1 proteins decrease, resulting in impaired host defense and increased 〈i〉H. pylori〈/i〉 colonization. Our results suggest that MMP-10 facilitates 〈i〉H. pylori〈/i〉 persistence and promotes gastritis.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Improve traffic death statistics in China (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Improve traffic death statistics in China (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-11-09
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    RIT1 oncoproteins escape LZTR1-mediated proteolysis (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉RIT1 oncoproteins have emerged as an etiologic factor in Noonan syndrome and cancer. Despite the resemblance of RIT1 to other members of the Ras small guanosine triphosphatases (GTPases), mutations affecting RIT1 are not found in the classic hotspots but rather in a region near the switch II domain of the protein. We used an isogenic germline knock-in mouse model to study the effects of RIT1 mutation at the organismal level, which resulted in a phenotype resembling Noonan syndrome. By mass spectrometry, we detected a RIT1 interactor, leucine zipper–like transcription regulator 1 (LZTR1), that acts as an adaptor for protein degradation. Pathogenic mutations affecting either RIT1 or LZTR1 resulted in incomplete degradation of RIT1. This led to RIT1 accumulation and dysregulated growth factor signaling responses. Our results highlight a mechanism of pathogenesis that relies on impaired protein degradation of the Ras GTPase RIT1.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    White collar-1, a DNA binding transcription factor and a light sensor (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-07-06
    Description: Blue light regulates many physiological processes in fungi, but their photoreceptors are not known. In Neurospora crassa, all light responses depend on the Per-Arnt-Sim (PAS) domain-containing transcription factor white collar-1 (wc-1). By removing the WC-1 light, oxygen, or voltage domain, a specialized PAS domain that binds flavin mononucleotide in plant phototropins, we show that light responses are abolished, including light entrainment of the circadian clock. However, the WC-1-mediated dark activation of frq remains normal in this mutant, and the circadian clock can be entrained by temperature. Furthermore, we demonstrate that the purified Neurospora WC-1-WC-2 protein complex is associated with stoichiometric amounts of the chromophore flavin-adenine dinucleotide. Together, these observations suggest that WC-1 is the blue-light photoreceptor for the circadian clock and other light responses in Neurospora.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Qiyang -- Cheng, Ping -- Yang, Yuhong -- Wang, Lixing -- Gardner, Kevin H -- Liu, Yi -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):840-3. Epub 2002 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098705" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Circadian Rhythm/radiation effects ; Color ; DNA, Fungal/genetics/metabolism ; DNA-Binding Proteins/chemistry/deficiency/genetics/*metabolism ; Darkness ; Dimerization ; Flavin Mononucleotide/metabolism ; Flavin-Adenine Dinucleotide/metabolism ; Fungal Proteins/chemistry/genetics/metabolism ; Gene Deletion ; Gene Expression Regulation, Fungal/radiation effects ; *Light ; Molecular Sequence Data ; Neurospora crassa/genetics/*metabolism/radiation effects ; Oxygen/metabolism ; Photoreceptors, Microbial/chemistry/genetics/*metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Structure, Tertiary ; Response Elements/genetics ; Temperature ; Transcription Factors/chemistry/deficiency/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Chemical bond-making, bond-breaking, and electron transfer in solution (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-01-26
    Description: A method is described for determining heats of heterolysis, DeltaH(het), from the heats of reaction of resonancestabilized carbenium ions with carbanions in solution. These results can be converted into heats of homolysis, DeltaH(homo), for the same bonds by combining DeltaH(het) values with electron transfer energies, deltaG(ET) (deltaG(ET) approximately deltaH(ET)), obtained from redox potentials of the reacting ions. The results provide a comprehensive tabulation of DeltaH(het), DeltaH(homo), and DeltaG(ET) values for an extended series of organic compounds and are examined in terms of their interrelationships and a number of related properties of the ions and radicals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnett, E M -- Amarnath, K -- Harvey, N G -- Cheng, J P -- New York, N.Y. -- Science. 1990 Jan 26;247(4941):423-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17788608" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Direct observation of nodes and twofold symmetry in FeSe superconductor (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-06-18
    Description: We investigated the electron-pairing mechanism in an iron-based superconductor, iron selenide (FeSe), using scanning tunneling microscopy and spectroscopy. Tunneling conductance spectra of stoichiometric FeSe crystalline films in their superconducting state revealed evidence for a gap function with nodal lines. Electron pairing with twofold symmetry was demonstrated by direct imaging of quasiparticle excitations in the vicinity of magnetic vortex cores, Fe adatoms, and Se vacancies. The twofold pairing symmetry was further supported by the observation of striped electronic nanostructures in the slightly Se-doped samples. The anisotropy can be explained in terms of the orbital-dependent reconstruction of electronic structure in FeSe.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Song, Can-Li -- Wang, Yi-Lin -- Cheng, Peng -- Jiang, Ye-Ping -- Li, Wei -- Zhang, Tong -- Li, Zhi -- He, Ke -- Wang, Lili -- Jia, Jin-Feng -- Hung, Hsiang-Hsuan -- Wu, Congjun -- Ma, Xucun -- Chen, Xi -- Xue, Qi-Kun -- New York, N.Y. -- Science. 2011 Jun 17;332(6036):1410-3. doi: 10.1126/science.1202226.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory for Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, the People's Republic of China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21680839" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Mouse brain organization revealed through direct genome-scale TF expression analysis (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, Paul A -- Fu, Hui -- Luo, Ping -- Zhao, Qing -- Yu, Jing -- Ferrari, Annette -- Tenzen, Toyoaki -- Yuk, Dong-In -- Tsung, Eric F -- Cai, Zhaohui -- Alberta, John A -- Cheng, Le-Ping -- Liu, Yang -- Stenman, Jan M -- Valerius, M Todd -- Billings, Nathan -- Kim, Haesun A -- Greenberg, Michael E -- McMahon, Andrew P -- Rowitch, David H -- Stiles, Charles D -- Ma, Qiufu -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2255-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618518" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Brain/anatomy & histology/embryology/*growth & development/*metabolism ; Cloning, Molecular ; Corpus Striatum/anatomy & histology/embryology/growth & development/metabolism ; DNA Primers ; Databases, Factual ; *Gene Expression Profiling ; *Genome ; Hypothalamus/anatomy & histology/embryology/growth & development/metabolism ; In Situ Hybridization ; Mesencephalon/anatomy & histology/embryology/growth & development/metabolism ; Mice ; Neocortex/anatomy & histology/embryology/growth & development/metabolism ; Polymerase Chain Reaction ; Rhombencephalon/anatomy & histology/embryology/growth & development/metabolism ; Spinal Cord/anatomy & histology/embryology/growth & development/metabolism ; Thalamus/anatomy & histology/embryology/growth & development/metabolism ; Transcription Factors/*genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 9
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    Properties of metallic nanowires: from conductance quantization to localization (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-03-24
    Description: Material structures of reduced dimensions exhibit electrical and mechanical properties different from those in the bulk. Measurements of room-temperature electronic transport in pulled metallic nanowires are presented, demonstrating that the conductance characteristics depend on the length, lateral dimensions, state and degree of disorder, and elongation mechanism of the wire. Conductance during the elongation of short wires (length l approximately 50 angstroms) exhibits periodic quantization steps with characteristic dips, correlating with the order-disorder states of layers of atoms in the wire predicted by molecular dynamics simulations. The resistance R of wires as long as l approximately 400 angstroms exhibits localization characteristics with In R(l) approximately l(2).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pascual, J I -- Mendez, J -- Gomez-Herrero, J -- Baro, A M -- Garcia, N -- Landman, U -- Luedtke, W D -- Bogachek, E N -- Cheng, H P -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1793-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17775806" target="_blank"〉PubMed〈/a〉
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    Electronic ISSN: 1095-9203
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  • 10
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    Design of a monomeric 23-residue polypeptide with defined tertiary structure (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-01-19
    Description: Small proteins or protein domains generally require disulfide bridges or metal sites for their stabilization. Here it is shown that the beta beta alpha architecture of zinc fingers can be reproduced in a 23-residue polypeptide in the absence of metal ions. The sequence was obtained through an iterative design process. A key feature of the final design is the incorporation of a type II' beta turn to aid in beta-hairpin formation. Nuclear magnetic resonance analysis reveals that the alpha helix and beta hairpin are held together by a defined hydrophobic core. The availability of this structural template has implications for the development of functional polypeptides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Struthers, M D -- Cheng, R P -- Imperiali, B -- New York, N.Y. -- Science. 1996 Jan 19;271(5247):342-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8553067" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Circular Dichroism ; DNA-Binding Proteins/chemistry ; *Genes, Synthetic ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Sequence Data ; Peptides/*chemistry ; *Protein Engineering ; Protein Folding ; Protein Structure, Secondary ; *Protein Structure, Tertiary ; Proteins/*chemistry ; Transcription Factors/chemistry ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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