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  • American Association for the Advancement of Science (AAAS)  (11)
  • 2000-2004  (11)
  • 1970-1974
  • 1
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    Complete genome sequence of a virulent isolate of Streptococcus pneumoniae (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-07-21
    Beschreibung: The 2,160,837-base pair genome sequence of an isolate of Streptococcus pneumoniae, a Gram-positive pathogen that causes pneumonia, bacteremia, meningitis, and otitis media, contains 2236 predicted coding regions; of these, 1440 (64%) were assigned a biological role. Approximately 5% of the genome is composed of insertion sequences that may contribute to genome rearrangements through uptake of foreign DNA. Extracellular enzyme systems for the metabolism of polysaccharides and hexosamines provide a substantial source of carbon and nitrogen for S. pneumoniae and also damage host tissues and facilitate colonization. A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low-guanine/cytosine (GC) Gram-positive species. Several surface-exposed proteins that may serve as potential vaccine candidates were identified. Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tettelin, H -- Nelson, K E -- Paulsen, I T -- Eisen, J A -- Read, T D -- Peterson, S -- Heidelberg, J -- DeBoy, R T -- Haft, D H -- Dodson, R J -- Durkin, A S -- Gwinn, M -- Kolonay, J F -- Nelson, W C -- Peterson, J D -- Umayam, L A -- White, O -- Salzberg, S L -- Lewis, M R -- Radune, D -- Holtzapple, E -- Khouri, H -- Wolf, A M -- Utterback, T R -- Hansen, C L -- McDonald, L A -- Feldblyum, T V -- Angiuoli, S -- Dickinson, T -- Hickey, E K -- Holt, I E -- Loftus, B J -- Yang, F -- Smith, H O -- Venter, J C -- Dougherty, B A -- Morrison, D A -- Hollingshead, S K -- Fraser, C M -- R01 AI40645-01A1/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Jul 20;293(5529):498-506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11463916" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, Bacterial ; Bacterial Proteins/chemistry/genetics/immunology/metabolism ; Bacterial Vaccines ; Base Composition ; Carbohydrate Metabolism ; Carrier Proteins/genetics/metabolism ; Chromosomes, Bacterial/genetics ; Computational Biology ; DNA Transposable Elements ; DNA, Bacterial/chemistry/genetics ; Gene Duplication ; Genes, Bacterial ; *Genome, Bacterial ; Hexosamines/metabolism ; Oligonucleotide Array Sequence Analysis ; Recombination, Genetic ; Repetitive Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Species Specificity ; Streptococcus pneumoniae/*genetics/immunology/metabolism/*pathogenicity ; Virulence ; rRNA Operon
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Evolution and immunology. The economics of immunity (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: Our vigilant immune systems are ready to mount an attack as soon as an invading pathogen is spotted. But what is the cost of keeping this sophisticated defense system on red alert? In a provocative Perspective, Read and Allen discuss new findings showing that the cost of immune defense in animals is very high (Moret and Schmid-Hempel), and the claim that, in some circumstances, the cost may be worth the benefit gained (Nunn et al.).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Read, A F -- Allen, J E -- New York, N.Y. -- Science. 2000 Nov 10;290(5494):1104-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK. a.read@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11185007" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bees/*immunology ; *Biological Evolution ; Female ; *Immunity ; Immunity, Active ; Immunity, Cellular ; Immunity, Innate ; Leukocyte Count ; Male ; Primate Diseases/immunology ; Primates/*immunology ; Selection, Genetic ; Sexual Behavior, Animal ; Sexually Transmitted Diseases/immunology/veterinary ; Species Specificity
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Further scrutiny of scientific whaling (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownell, R L -- Tillman, M F -- di Sciara, G N -- Berggren, P -- Read, A J -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1696.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186389" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antarctic Regions ; *Commerce ; Conservation of Natural Resources ; Japan ; *Research ; *Whales
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Plant biology. Prime time for cellulose (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Read, Steve M -- Bacic, Tony -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):59-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Resource Management and Forest Science Centre, University of Melbourne, Creswick, Victoria 3363, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778033" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Arabidopsis Proteins ; Binding Sites ; Carbohydrate Conformation ; Catalysis ; Cell Membrane/metabolism ; Cellulase ; Cellulose/*analogs & derivatives/*biosynthesis/metabolism ; Dextrins/metabolism ; Glucans/biosynthesis/metabolism ; Glucose/metabolism ; Glucosyltransferases/*metabolism ; Gossypium/enzymology/*metabolism ; Membrane Proteins/*metabolism ; Models, Biological ; Organisms, Genetically Modified ; Plants/enzymology/genetics/*metabolism ; Sitosterols/*metabolism ; Uridine Diphosphate Glucose/metabolism ; Yeasts/genetics/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    The ecology of genetically diverse infections (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-05-16
    Beschreibung: Microparasite infections often consist of genetically distinct clonal lineages. Ecological interactions between these lineages within hosts can influence disease severity, epidemiology, and evolution. Many medical and veterinary interventions have an impact on genetic diversity within infections, but there is little understanding of the long-term consequences of such interventions for public and animal health. Indeed, much of the theory in this area is based on assumptions contradicted by the available data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Read, A F -- Taylor, L H -- New York, N.Y. -- Science. 2001 May 11;292(5519):1099-102.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK. a.read@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11352063" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacteria/genetics/pathogenicity ; Bacterial Infections/epidemiology/*microbiology/therapy/transmission ; *Biological Evolution ; Drug Resistance/genetics ; Ecology ; Genetic Variation/*genetics ; Humans ; Malaria/parasitology ; Parasitic Diseases/epidemiology/*parasitology ; Plasmodium/genetics/physiology ; Selection, Genetic ; Virulence/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Managing climate risk (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-10-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Obersteiner, M -- Azar, C -- Kauppi, P -- Mollersten, K -- Moreira, J -- Nilsson, S -- Read, P -- Riahi, K -- Schlamadinger, B -- Yamagata, Y -- Yan, J -- van Ypersele, J P -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):786-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11681318" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-11
    Beschreibung: Comparison of the whole-genome sequence of Bacillus anthracis isolated from a victim of a recent bioterrorist anthrax attack with a reference reveals 60 new markers that include single nucleotide polymorphisms (SNPs), inserted or deleted sequences, and tandem repeats. Genome comparison detected four high-quality SNPs between the two sequenced B. anthracis chromosomes and seven differences among different preparations of the reference genome. These markers have been tested on a collection of anthrax isolates and were found to divide these samples into distinct families. These results demonstrate that genome-based analysis of microbial pathogens will provide a powerful new tool for investigation of infectious disease outbreaks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Read, Timothy D -- Salzberg, Steven L -- Pop, Mihai -- Shumway, Martin -- Umayam, Lowell -- Jiang, Lingxia -- Holtzapple, Erik -- Busch, Joseph D -- Smith, Kimothy L -- Schupp, James M -- Solomon, Daniel -- Keim, Paul -- Fraser, Claire M -- R01-LM06845/LM/NLM NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2028-33. Epub 2002 May 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA., Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004073" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anthrax/microbiology ; Bacillus anthracis/classification/*genetics/isolation & ; purification/pathogenicity ; Bacterial Typing Techniques ; Base Sequence ; Bioterrorism ; Chromosome Inversion ; Computational Biology ; Disease Outbreaks ; Genetic Markers ; *Genetic Variation ; *Genome, Bacterial ; Genomics ; Humans ; Minisatellite Repeats ; Molecular Sequence Data ; Mutation ; Phenotype ; Phylogeny ; Plasmids ; *Polymorphism, Single Nucleotide ; Recombination, Genetic ; Repetitive Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Sequence Deletion ; Species Specificity ; Transposases/genetics ; Virulence/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Temperatures, winds, and composition in the saturnian system (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-12-25
    Beschreibung: Stratospheric temperatures on Saturn imply a strong decay of the equatorial winds with altitude. If the decrease in winds reported from recent Hubble Space Telescope images is not a temporal change, then the features tracked must have been at least 130 kilometers higher than in earlier studies. Saturn's south polar stratosphere is warmer than predicted from simple radiative models. The C/H ratio on Saturn is seven times solar, twice Jupiter's. Saturn's ring temperatures have radial variations down to the smallest scale resolved (100 kilometers). Diurnal surface temperature variations on Phoebe suggest a more porous regolith than on the jovian satellites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flasar, F M -- Achterberg, R K -- Conrath, B J -- Pearl, J C -- Bjoraker, G L -- Jennings, D E -- Romani, P N -- Simon-Miller, A A -- Kunde, V G -- Nixon, C A -- Bezard, B -- Orton, G S -- Spilker, L J -- Spencer, J R -- Irwin, P G J -- Teanby, N A -- Owen, T C -- Brasunas, J -- Segura, M E -- Carlson, R C -- Mamoutkine, A -- Gierasch, P J -- Schinder, P J -- Showalter, M R -- Ferrari, C -- Barucci, A -- Courtin, R -- Coustenis, A -- Fouchet, T -- Gautier, D -- Lellouch, E -- Marten, A -- Prange, R -- Strobel, D F -- Calcutt, S B -- Read, P L -- Taylor, F W -- Bowles, N -- Samuelson, R E -- Abbas, M M -- Raulin, F -- Ade, P -- Edgington, S -- Pilorz, S -- Wallis, B -- Wishnow, E H -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1247-51. Epub 2004 Dec 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Aeronautics and Space Administration (NASA)/Goddard Space Flight Center, Code 693, Greenbelt, MD 20771, USA. f.m.flasar@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618486" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Atmosphere ; Carbon ; Extraterrestrial Environment ; Hydrogen ; Methane ; *Saturn ; Spacecraft ; Spectrum Analysis ; Temperature ; Wind
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Jupiter's atmospheric composition from the Cassini thermal infrared spectroscopy experiment (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-08-21
    Beschreibung: The Composite Infrared Spectrometer observed Jupiter in the thermal infrared during the swing-by of the Cassini spacecraft. Results include the detection of two new stratospheric species, the methyl radical and diacetylene, gaseous species present in the north and south auroral infrared hot spots; determination of the variations with latitude of acetylene and ethane, the latter a tracer of atmospheric motion; observations of unexpected spatial distributions of carbon dioxide and hydrogen cyanide, both considered to be products of comet Shoemaker-Levy 9 impacts; characterization of the morphology of the auroral infrared hot spot acetylene emission; and a new evaluation of the energetics of the northern auroral infrared hot spot.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kunde, V G -- Flasar, F M -- Jennings, D E -- Bezard, B -- Strobel, D F -- Conrath, B J -- Nixon, C A -- Bjoraker, G L -- Romani, P N -- Achterberg, R K -- Simon-Miller, A A -- Irwin, P -- Brasunas, J C -- Pearl, J C -- Smith, M D -- Orton, G S -- Gierasch, P J -- Spilker, L J -- Carlson, R C -- Mamoutkine, A A -- Calcutt, S B -- Read, P L -- Taylor, F W -- Fouchet, T -- Parrish, P -- Barucci, A -- Courtin, R -- Coustenis, A -- Gautier, D -- Lellouch, E -- Marten, A -- Prange, R -- Biraud, Y -- Ferrari, C -- Owen, T C -- Abbas, M M -- Samuelson, R E -- Raulin, F -- Ade, P -- Cesarsky, C J -- Grossman, K U -- Coradini, A -- New York, N.Y. -- Science. 2004 Sep 10;305(5690):1582-6. Epub 2004 Aug 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, University of Maryland, College Park, MD 20742, USA. Virgil.G.Kunde.1@gsfc.nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15319491" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylene ; Atmosphere ; *Carbon Dioxide ; Ethane ; Extraterrestrial Environment ; *Hydrocarbons ; *Hydrogen Cyanide ; *Jupiter ; Spacecraft ; Spectrum Analysis ; Temperature
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-03-29
    Beschreibung: The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paulsen, I T -- Banerjei, L -- Myers, G S A -- Nelson, K E -- Seshadri, R -- Read, T D -- Fouts, D E -- Eisen, J A -- Gill, S R -- Heidelberg, J F -- Tettelin, H -- Dodson, R J -- Umayam, L -- Brinkac, L -- Beanan, M -- Daugherty, S -- DeBoy, R T -- Durkin, S -- Kolonay, J -- Madupu, R -- Nelson, W -- Vamathevan, J -- Tran, B -- Upton, J -- Hansen, T -- Shetty, J -- Khouri, H -- Utterback, T -- Radune, D -- Ketchum, K A -- Dougherty, B A -- Fraser, C M -- AI40963-02/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2003 Mar 28;299(5615):2071-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12663927" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adhesins, Bacterial/genetics ; Bacterial Adhesion ; Bacterial Proteins/genetics ; *Biological Evolution ; Carrier Proteins/genetics/metabolism ; Chromosomes, Bacterial/genetics ; Conjugation, Genetic ; Conserved Sequence ; DNA Transposable Elements ; Digestive System/microbiology ; Drug Resistance, Multiple, Bacterial ; Enterococcus faecalis/drug effects/*genetics/pathogenicity/physiology ; Gene Transfer, Horizontal ; *Genome, Bacterial ; Gram-Positive Bacterial Infections/microbiology ; Humans ; *Interspersed Repetitive Sequences ; Lysogeny ; Open Reading Frames ; Oxidative Stress ; Plasmids ; *Sequence Analysis, DNA ; Synteny ; Vancomycin Resistance/*genetics ; Virulence/genetics ; Virulence Factors/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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