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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 9 (1976), S. 387-392 
    ISSN: 1432-1041
    Keywords: Defibrinogenisation ; peripheral arterial disease ; clinical trial design ; medical statistics ; sequential analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of Arwin® on peripheral arterial occlusive disease has been studied in two multicentre trials. In the first, in cases of severe peripheral arterial circulatory disorders of the lower extremities with permanent rest pain (stages III and III + IV according to Fontaine) Arwin® had a better intravenous therapeutic effect than anticoagulant treatment. A further trial was done to investigate whether subcutaneous administration of Arwin® would have an effect superior to classical conservative therapy with vasodilator drugs in this type of disease. The results were assessed by sequential analysis. Arwin® was again shown to be a much better treatment. Problems of medical documentation and statistics are discussed in relation to the value of sequential analysis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 10 (1976), S. 101-108 
    ISSN: 1432-1041
    Keywords: Cardiac glycosides ; methyl proscillaridin ; plasma concentrations ; electrocardiogram ; bioavailability ; 86Rb-erythrocyte assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The aim of this study was to obtain data about the pharmacological properties of a new glycoside derivative in man. Plasma concentrations and ECG parameters were measured after oral and intravenous administration of a single dose of 1.2 mg methyl proscillaridin in 16 healthy volunteers, using a strictly randomized, two-period change-over design. Glycoside concentrations were measured using a modified86Rb-erythrocyte-assay. QT-duration, corrected for frequency (QTc), was the principal variable measured in the ECG. By either route, there was a maximum plasma level after 1 hour, which had decreased to a minimum at 3 hours, followed by a second peak at 4 to 10 hours (orally〉iv). From 10 to 72 hours the concentrations decreased with a median t 1/2 of 23.3 hours (iv) and 33.0 hours (orally). Comparison of the ratio of plasma concentrations following oral and iv administration resulted in a bioavailability of 69 % using the 48 hour plasma levels, and 59 % using the areas under the concentration-time curves. The mean QTc was maximally shortened to 28 msec at 1 hour after iv and to 19 msec at 10 hours after the oral dose. A distinct similarity between time-concentration and time-QTc curves was seen after the initial distribution phase, both after oral and intravenous administration. The new derivative shows a rapid elimination. Its bioavailability is reasonably high.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 30 (1979), S. 853-857 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Ion bombardment - a method for Investigating and preventingDuring the last years the technique of ion implantation gained increasing importance. It allows to introduce very element at any temperature in any material and to produce stable as well as metastable alloys. Applications for this method in corrosion science are pointed out in the light of results from different laboratories.First the stability of titanium and zirconium against thermal oxidation after ion bombardment is discussed. Then the passivation behaviour of iron irradiated with chromium and tantalum ions is mentioned. The third section deals with aqueous corrosion of iron and hydrogen evolution in diluted acids. The implantation of lead, gold and platinum is shown to modify the reaction rates by several orders of magnitude. Finally the possibility of using ion bombardment for the investigation of hydrogen embrittlement of metals is demonstrated.The results prove this method for the formation of alloys to allow studies being not accessible with more conventional techniques.
    Notes: In den letzten Jahren hat die Technik der Ionenbestrahlung von Materialien steigende Bedeutung gewonnen. Sie gestattet es, beliebige Elemente bei jeder Temperature in beliebige Basismaterialien einzubringen und sowohl stabile als auch metastabile Oberflächenlegierungen herzustellen. An Hand einer Reihe von Beispielen aus in- und ausländischen Labors werden Anwendungsmöglichkeiten in der Korrosionsforschung vorgestellt.Zunächst wird die Oxidationsbeständigkeit von mit Ionen bestrahltem Titan und Zirkon diskutiert, sodann das Passivierungsverhalten von Eisen, das mit Chrom- und Tantalionen beschossen wurde. Der Befund, daß die Korrosionsgeschwindigkeit und die Wasserstoffentwicklungsrate von Eisen in verdünnter Säure durch Implantation von Blei-, Gold-und Platinionen um mehrere Zehnerpotenzen verändert werden können, wird mitgeteilt. Schließlich wird die Möglichkeit, Ionenbeschuß zur Untersuchung der Wasserstoffversprödung von Metallen heranzuziehen, aufgezeigt. Die Ergebnisse beweisen, daß diese „Legierungsmethode“ Untersuchungen ermöglicht, die mit konventionellen Techniken kaum zugänglich sind.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 1976-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 5
    Publication Date: 1976-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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