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  • 1
    Electronic Resource
    Electronic Resource
    Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 287-293 
    Details
    ISSN: 1432-1041
    Keywords: Rifampicin ; induction of drug metabolism ; cirrhosis ; cholestasis ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased more than two-fold and that of tolbutamide almost two-fold. The results suggest that rifampicin is able to stimulate hepatic drug metabolism in patients with liver disease. It was apparent in general that the induction did not lead to improvement of hepatocellular function during disease as judged by laboratory findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607679
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  • 2
    Electronic Resource
    Electronic Resource
    Minority-carrier kinetics in heavily doped GaAs:C studied by transient photoluminescence (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 5072-5078 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Room-temperature photoluminescence decay time measurements in heavily doped GaAs:C-layers designed as base layers for heterojunction bipolar transistors are reported. These measurements provide access to nonequilibrium minority carrier lifetimes that determine the current gains of those devices. By systematically studying transient luminescence spectra over a wide range of excitation densities between 1013 and 1018 cm−3, we demonstrate the importance of carrier trapping processes at low excitation densities. Optimized excitation conditions that achieve trap saturation but also avoid stimulated emission are found for densities of (1–3)×1017 cm−3/pulse. Detection is limited to a spectral window well above the energy gap (beyond 1.5 eV). Values for both Auger and radiative recombination coefficients are given. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1456244
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  • 3
    Electronic Resource
    Electronic Resource
    Gold electrodes from recordable CDs for mercury quantification by flow injection analysis (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 444-448 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The development of a new methodology for the construction of very efficient flow cells for mercury detection by potentiometric stripping analysis, employing the thin gold layer of recordable CDs as working ¶electrode is reported. This new source of electrodes (CDtrodes) show very attractive performance, similar to that obtained with commercial gold electrodes, with superior versatility. The low cost of this new source of “gold electrodes” allows a frequent replacement of the electrode, avoiding cumbersome clean-up treatments. Various experimental parameters have been optimized to yield low detection limits (0.25 ng/mL of mercury for 5 min deposition at 0.3 V) and good precision (standard deviation of 1.9% was obtained for 15 repetitive measurements using 10 ng/mL of mercury). Standard curves were found to be linear over the range of 0.5–100 μg L–1 of mercury. The flow cells developed were used for the quantification of mercury in oceanic and tap water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050090
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 219-227 
    Details
    ISSN: 1432-1041
    Keywords: Rifampicin ; induction of drug metabolism ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five healthy volunteers took 1.2 g rifampicin daily for 8 days, and before and afterwards each received hexobarbital (7.32 mg/kg) and tolbutamide (20 mg/kg) by i.v. infusion on two consecutive days. The plasma concentrations of the two drugs were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 325 to 122 min and of tolbutamide from 418 to 183 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased about three-fold and that of tolbutamide more than two-fold. Significant changes in the distribution kinetics of the two drugs were not observed. The results suggest that rifampicin is capable of inducing drug metabolism in man, which leads to an increased rate of elimination of drugs that undergo biotransformation in the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614021
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  • 5
    Electronic Resource
    Electronic Resource
    Mischungen von primären aliphatischen Alkoholen mit Chlorex und anderen organischen Stoffen (1949)
    Springer
    Monatshefte für Chemie 80 (1949), S. 749-758 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Zusammenfassung 1. Die untersuchten Chlorex-n-Alkoholsysteme zeigen hohe endotherme Mischungswärmen, die sich mit steigender Temperatur noch vergrößern. 2. Bei den niederen Alkoholsystemen treten Volumkontraktionen, bei den höheren Volumdilatationen auf. 3. Das System Chlorex-Methanol ist in flüssiger Phase unbeschränkt mischbar; sämtliche anderen Alkoholsysteme besitzen Mischungslücken. Die KLT-Werte steigen mit wachsendem Molgewicht des Alkohols an, und zwar ab C3H7OH ziemlich regelmäßig oszillierend. 4. Mit steigendem Molgewicht der Alkohole verschieben sich die ΔH max-Werte in das Alkohol-reichere, dagegen die ΔV max- und KLT-Werte ins Chlorex-reichere Gebiet. Die Systemreihen n-Alkohole-Benzol und n-Alkohole-n-Hexan weisen ganz ähnliche Anomalien auf, die offenbar in der Assoziation und dem mit der Temperatur veränderlichen Assoziationsgrad der Alkoholkomponente begründet sind. 5. Chlorex stellt für die niederen n-Alkohole ein selektives Lösungsmittel dar, währendAnilin mit denselben Alkoholen (bis C8H17OH) in flüssiger Phase unbeschränkt mischbar ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00898375
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  • 6
    Electronic Resource
    Electronic Resource
    Über binäre flüssige Mischungen X (1949)
    Springer
    Monatshefte für Chemie 80 (1949), S. 510-516 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00899155
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  • 7
    Electronic Resource
    Electronic Resource
    Über die Mischbarkeit von Chlorex (β,β′-Dichlordiäthyläther) mit Halogenkohlenwasserstoffen (1949)
    Springer
    Monatshefte für Chemie 80 (1949), S. 856-863 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00898388
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  • 8
    Electronic Resource
    Electronic Resource
    Die Mischungen von Chlorex mit n-Oktan und 2,2,4-Trimethylpentan (1949)
    Springer
    Monatshefte für Chemie 80 (1949), S. 572-582 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Zusammenfassung 1. Die Mischungswärmen der SystemeChlorex—n-Oktan undChlorex—i-Oktan (2,2,4-Trimethylpentan) sind bei 25°C sehr starkendotherm (495, bzw. 440 cal/Mol Mischung bei XChl=0,300) und besitzen einennegativen Temperaturkoeffizienten. 2. Das SystemChlorex—n-Oktan zeigt bei 20°C — das heißt bei eben noch vollständiger gegenseitiger Löslichkeit — eine kleine Volums-dilatation, die sich mit steigender Temperatur (35°) vorerst nur wenig ändert, dann aber (50°) deutlich ausgeprägt ist. Das SystemChlorex—i-Oktan weist bei 20°C — also noch sehr nahe der KLT — eine geringfügige Volumskontraktion auf, die bei 35° noch ebenso gering ist, dann aber (50°) bemerkenswert groß wird. 3. Das Dipolmoment desChlorex-Einzelmoleküls errechnet sich bei 20°C zu 2,47 (Debye) in n-Oktan und 2,60 (Debye) in i-Oktan. 4. Die Zustandsdiagramme beider Systeme sind sehr ähnlich und zeigen tiefe, fast über den gesamten Konzentrationsbereich laufende Zonen beschränkter Mischbarkeit. Die KLT desChlorex—n-Oktan-systems liegt bei+19,7°C, die des i-Oktansystems bei+18,2°C. Für die Schmelzwärme vonChlorex finden wir als Mittelwert 2070 cal/Mol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00899161
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  • 9
    Electronic Resource
    Electronic Resource
    Hydroxyapatite nucleation on Na ion implanted Ti surfaces (2000)
    Springer
    Journal of materials science 19 (2000), S. 1029-1031 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006782818468
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  • 10
    Electronic Resource
    Electronic Resource
    Surface sensitivity of ion implanted titanium to hydroxyapatite formation (2000)
    Springer
    Journal of materials science 19 (2000), S. 443-445 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006759309358
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