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  • Springer  (84)
  • 1980-1984  (52)
  • 1975-1979  (15)
  • 1920-1924  (1)
  • 1905-1909  (16)
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  • 1
    ISSN: 1432-1424
    Keywords: plasma membrane ; lung ; histamine receptors ; 5′ nucleotidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary A simple and rapid method of isolating plasma membranes from human peripheral lung tissue is described. The method involves homogenization of tissue in 0.25m sucrose-buffered medium followed by differential and sucrose density gradient centrifugation. Enzymatic and morphological characterization of the plasma membrane fraction revealed minimal contamination by nonplasma membrane fragments. The isolated plasma membranes showed an 18-fold purification of 5′-nucleotidase activity compared to the original homogenate. Electronmicroscopic studies of the plasma membrane fraction revealed the presence of small membrane vesicles having a trilaminar membrane structure. To further examine the purity of the plasma membrane preparation, the binding of the H1 receptor antagonist,3H pyrilamine, to the plasma membrane-enriched fraction was compared to the binding to crude membrane preparations. Both the plasma membrane-enriched fraction and the crude membrane preparation had similar Kd's for the histamine antagonist, but the plasma membrane-enriched fraction had a threefold greater binding capacity, reflecting the relative enrichment of plasma membranes of the preparation. Thus, a method has been developed for the isolation of plasma membranes from human peripheral lung which should provide material for a variety of biochemical and pharmacological studies.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 33 (1981), S. 545-548 
    ISSN: 1432-0827
    Keywords: calmodulin ; calcium ; mineralisation ; tooth germ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Calmodulin, a calcium binding protein, has been implicated in the regulation of many calcium-dependent biological processes. Since calcium has an important role in hard tissue genesis, both at intra- and extracellular levels, we anticipate that calcium binding proteins may modulate this process. The present study investigated a mineralising tissue, the rat molar tooth germ, to determine the presence of calmodulin-like activity. A heat-treated cell-free extract of tooth germs provided enhancement of Ca2+-dependent Mg2+-ATPase and 3′:5′-nucleotide phosphodiesterase activity. No enhancement occurred in the absence of calcium or in the presence of trifluoperazine. SDS-polyacrylamide gel electrophoresis of this extract revealed a protein band of approximately 18,000 mol. wt. These findings indicate the presence of calmodulin-like activity in rat molar tooth germs and support the proposal that calcium and calcium binding proteins, in particular calmodulin, have a major regulatory role in the biology of mineralising tissues.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Meteorology and atmospheric physics 26 (1977), S. 39-50 
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Description / Table of Contents: Zusammenfassung Im Dezember 1975 wurden durch eine Fesselballonsonde die vertikalen Temperatur- und Windprofile im Gore River Valley im westlichen Colorado ermittelt. Aus Beobachtungen an einem wolkenlosen Morgen bei einer anfangs starken Inversion im Tal zeigte sich, daß die Inversionsobergrenze stetig um 120 m Std−1. absank und nach ungefähr vier Stunden den Talgrund erreichte. Schwache Talabwinde wehten innerhalb der Inversionsschicht. während stärkere Talaufwinde oberhalb derselben herrschten. Eine Hypothese wird vorgeschlagen, um diese Beobachtungen zu erklären. Die Abkühlung am späten Nachmittag und am Abend, wobei die Bildung einer Inversion einsetzte, deren Schichtdicke in weniger als zwei Stunden 175 m betrug, ist Gegenstand einer gesonderten Untersuchung. Winde innerhalb der Inversionsschicht wurden nicht mehr von den Winden in der freien Atmosphäre beeinflußt und blieben im Laufe der Nacht sehr schwach. Bewölkung während der Erwärmungsperiode an einem Morgen hatte zur Folge, daß das Temperaturprofil sich Isothermie näherte, indem Erwärmung gleichmäßig im ganzen Luftraum des Tales sich fortsetzte.
    Notes: Summary A tethered balloon sounder was used to collect vertical temperature and wind structure data in the Gore River Valley of Western Colorado during December, 1975. Observations taken on a clear morning in which a deep inversion was initially present in the valley showed that the inversion top descended at a steady rate of ∼120 m hr−1. reaching the valley bottom after approximately 4 hours. Weak down-valley winds were present within the inversion layer while stronger up-valley winds prevailed above. A hypothesis is presented to account for these observations. A case study is presented for afternoon and evening cooling in which a ground-based inversion developed to a depth of 175 m in less than 2 hours. Winds within the inversion became decoupled from the synoptic-scale winds and remained very weak during the night. The effect of cloud cover during a morning heating cycle was to make the temperature soundings approach isothermal while sensible heating continued throughout the valley volume.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Geo-marine letters 4 (1984), S. 207-210 
    ISSN: 1432-1157
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Sedimentological, geochemical, and physical-oceanographic studies of the Brazilian continental shelf near the Amazon River help provide a broad understanding of this major sediment dispersal system. Amazon River sediment accumulates as a subaqueous delta, with the most rapid accumulation (∼10 cm/yr) occurring near the seaward edge of the topset beds and in the foreset beds. Amazon River sediment is dispersed northwestward along the shelf and is transported beyond the Brazilian border. Radiographic studies of sediment cores delineate three sedimentary environments: interbedded mud and sand, faintly laminated mud, and bioturbated mud. The distribution of these environments is a function of proximity to the river mouth and of sediment accumulation rate.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Reviews of physiology, biochemistry and pharmacology 23 (1924), S. 212-273 
    ISSN: 1617-5786
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Zusammenfassung Kurz zusammengefasst sind die wichtigsten, hier niedergelegten Tatsachen folgende: Es wurde eine Methode für die totale Entfernung der Leber bei Hunden ausgebildet, welche frei von den meisten Fehlerquellen ist, die früheren Exstirpationsmethoden des Organs bei Säugetieren anhaften. Es wurde gefunden, dass eine geeignete Einführung von Glukose bei derart operierten Hunden das Leben viele Stunden nach Verlust des gesamten Lebergewebes erhält. Von den vielen an hepatektomierten Tieren gemachten Beobachtungen möchten wir hervorheben, 1. dass die Leber zur Erhaltung des Blutzuckerspiegels absolut wesentlich ist; 2. dass die Leber der wichtigste Faktor, wenn nicht der einzige, bei dem Prozess der Desamidierung und der Harnstoffbildung ist, und 3. dass Bilirubin auch ohne Mitwirkung der Leber gebildet werden kann.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 29 (1982), S. 731-733 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 30 (1983), S. 99-104 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 30 (1983), S. 58-64 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Conclusions Pollution abatement technologies instituted by recycling paper mills have resulted in a decrease in PCBs in final effluents discharged to the Lower Fox River. Concurrent declines in fish PCB body burdens have also been noted. It is not certain, however, whether the resultant decrease in PCB final effluent concentrations is sufficient to protect aquatic life from bioaccumulation of PCBs above an acceptable level. Furthermore, sediment PCB concentrations remain high in previously impacted areas.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 29 (1982), S. 68-75 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 31 (1983), S. 526-529 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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