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  • 1
    Electronic Resource
    Electronic Resource
    Cell free system from HeLa cells active in initiation of protein synthesis (1975)
    s.l. : American Chemical Society
    Biochemistry 14 (1975), S. 5315-5321 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00695a015
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  • 2
    Electronic Resource
    Electronic Resource
    Materials of LIGA technology (1999)
    Springer
    Microsystem technologies 5 (1999), S. 105-112 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract  The progress in microfabrication technologies is currently characterized by an increasing number of microproducts and corresponding efforts for cost effective mass fabrication. In this context, the development and utilization of new application specific materials has become one of the key challenges for the commercial production of miniaturized functional units. This applies, in particular, to the LIGA technique, a sequence of process steps combining deep lithography, microelectroforming and micromoulding, which offers an extremely broad spectrum of materials for the generation of ultraprecise three-dimensional microstructures. A wide variety of polymers, metals, metal alloys and ceramic materials are by now accessible for fabricating microdevices. There are practically no major limitations in selecting the desired material properties, e.g. in respect of mechanical stiffness or biocompatibility, optical transparency or magnetic properties, resistance against corrosion or whatever is required by the specific function of a microdevice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050150
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  • 3
    Electronic Resource
    Electronic Resource
    Miniaturized plastic micro plates for applications in HTS (1999)
    Springer
    Microsystem technologies 6 (1999), S. 48-53 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract This paper is focused on the development of plastic nano titer plates for applications in high throughput screening (HTS). For screening systems with integrated confocal microscopes plastic chips have been fabricated by injection molding and injection compression molding which contain micro wells with volumes of 0.9 μl and 1.4 μl and bottom plates with thicknesses of 120 μm and 200 μm. In addition, plastic chips with through holes have been joined with 160 μm glass plates by an adhesive printing process. First fluorescence correlation spectroscopy (FCS) measurements show that the plastic plates with glass bottoms are qualified as screening grade FCS nano titer plates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050174
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  • 4
    Electronic Resource
    Electronic Resource
    Measurements of the vapor pressures of difluoromethane, 1-chloro-1,2,2,2-tetrafluoroethane, and pentafluoroethane. [Erratum to document cited in CA121:187948] (1995)
    s.l. : American Chemical Society
    Journal of chemical & engineering data 40 (1995), S. 1164-1164 
    Details
    ISSN: 1520-5134
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/je00021a031
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  • 5
    Electronic Resource
    Electronic Resource
    Incorporation of First-Order Uptake Rate Constants from Simple Mammillary Models into Blood-Flow Limited Physiological Pharmacokinetic Models via Extraction Efficiencies (1995)
    Springer
    Pharmaceutical research 12 (1995), S. 263-269 
    Details
    ISSN: 1573-904X
    Keywords: tissue uptake ; extraction efficiency ; blood flow-limited models ; 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Incorporation of First-Order Uptake Rate Constants from Simple Mammillary Models into Blood-Flow Limited Physiological Pharmacokinetic Models via Extraction Efficiencies. W. L. Roth, L. W. D. Weber, and K. Rozman (1995). Pharm. Res. 263–269. First-order rate constants obtained from classical pharmacokinetic models correspond to mammillary systems in which all of the blood (or plasma) is assumed to be located in a central compartment. In such models the rate at which chemicals are transported out of this pool and into another compartment is the product of the mass of chemical in the central compartment multiplied by a rate constant, which is not limited in magnitude by the blood flow, or the rate at which chemicals from the blood are delivered to the peripheral compartment. Most of the physiologically-based models published to date dispense with some of the information available from mammillary models by assuming that all of the chemical delivered by the flow of blood rapidly equilibrates and can be taken up by the tissue under the control of a “partition coefficient” (Rij = Cj/Ci). We show that the partition coefficient alone does not retain the uptake rate (kji) information available from a classical mammillary model, but that the uptake rate information can be incorporated via unitless extraction efficiency parameters, εj.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016239212118
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  • 6
    Electronic Resource
    Electronic Resource
    X-irradiation of mice in early fetal period influences dose-dependently sex ratio of offspring until weaning (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 541-543 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fractionated X-irradiation of mouse fetuses on gestation days 11–13 resulted in a significantly increased postnatal mortality of female litters. This occurred only at 3×110 rad, which was the threshold for the formation of typical neuroepithelial, rosette-like malformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922758
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  • 7
    Electronic Resource
    Electronic Resource
    Sexual dimorphism of mouse fetal brain lesions after X-irradiation prior to gonadal differentiation (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1653-1655 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fractionated X-irradiation of gestational days 11–13 in the mouse, with doses between 3×1.05 and 3×1.33 Gy resulted in rosette-like clusters of primitive ependym-resembling cells dispersed within the cortex walls. Quantification of these abnormalities showed a general prevalence in the female fetuses, especially due to the larger number of rosettes in the females than in the males. It was concluded that X-irradiation acts on sex-specific differentiation steps, which are fully developed at the beginning of the fetal period. At is was recently speculated that these are linked to an early divergence of gene expression between the sexes, we suggest that X-chromosome damage may be involved in the pathogenesis of the dimorphic lesion pattern. While, in principle, this will be valid for any fetal tissue, it only becames evident in the forebrain because of the outstanding relationship between cell necrosis and rosette development in this specific organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953250
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  • 8
    Electronic Resource
    Electronic Resource
    Sex-dependent action of prenatal fractionated X-irradiation in the mouse. Biochemical findings (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1656-1657 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary X-Irradiation of pregnant NMRI-mice on gestational days 11–13 with 3×1.05 Gy increased postnatal mortality of the female offspring only. Weights, protein content and acetylcholinesterase, as well as Na, K-ATPase activities in the brains of all treated offspring, were changed. There were, however, no differences between females and males with respect to these parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953251
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  • 9
    Electronic Resource
    Electronic Resource
    Design of a high-pressure ebulliometer, with vapor-liquid equilibrium results for the systems CHF2 Cl + CF3 CH3 and CF3 CH2 F + CH2F2 (1996)
    Springer
    International journal of thermophysics 17 (1996), S. 873-888 
    Details
    ISSN: 1572-9567
    Keywords: activity coefficients ; chlorodilluoromethane (R22) ; difluoromethane (R32) ; ebulliometry ; phase equilibriun ; refrigerant mixtures ; 1,1,1-trifluoroethane (R143a) ; 1,1,1,2-tetrafluoroethane (R134a)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We describe the design and operation of a new high-pressure metal ebulliometer which can operate at pressures to at least 3 MPa in the range 220–400 K. Infinite-dilution activity coefficients are presented for the system CHF2Cl + CF3-CH, at 275 K and for the system CF3-CH2F + CH2F2, at 260, 230, and 300 K. The Wilson activity coellicient model and a virial coefficient model are applied to these systems, and the phase equilibrium conditions are calculated. The results are shown to agree well with predicted and with published measured values. The excess enthalpy is calculated and compared with results from a Peng Robinson equation of state. Vapor densities on the dew curves are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01439194
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  • 10
    Electronic Resource
    Electronic Resource
    Dynamics of magnetospheric ion Composition as observed by the GEOS mass spectrometer (1978)
    Springer
    Space science reviews 22 (1978), S. 537-566 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract After one year of operation the GEOS-1 Ion Composition Experiment has surveyed plasma composition at all local times in the L range 3 ∼ 8 and the energy per charge range from thermal to 16 keV/e. From measurements made in the keV range during eleven magnetic storms we find that the percentage of heavy (M/Q 〉 1) ions present in the outer magnetosphere increases by a factor of 3 to 10 during disturbances. We conclude that two independent sources (solar wind, characterized by 4He2+, and ionosphere, characterized by O+) give on the average comparable contributions to injected populations, although in a single event one or the other source may dominate. However, in magnetically quiet periods protons are the dominant species with a few percent of heavy ions. With the help of special satellite manoeuvres magnetic field aligned fluxes of ≈0.05-3 keV/e H+, He+, O+ with traces of O2+ have been observed which may be related to ion beams found previously at lower altitudes in the auroral zone. At still lower energies (∼ 1 eV/e) the thermal plasma population is found to be made up of six ion species, three of which, D+, He2+ and O2+, were unknown in the magnetosphere prior to the GEOS-1 measurements. We present here a study of the evolution of doubly charged ions and their parent populations over four consecutive days. Various production mechanisms for doubly charged ions are discussed. We argue that ionization of singly charged ions by UV and energetic electrons and protons is the dominant process for plasmasphere production. Furthermore, the observed high concentrations of O2+ at high altitudes are a result of production in the upper ionosphere and plasmasphere combined with upward transport by thermal diffusion. Throughout the 1 year lifetime of GEOS-1 the ICE functioned perfectly and, because of its novel design, a short review of technical performance is included here.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223940
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