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Miniaturized plastic micro plates for applications in HTS

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Abstract

This paper is focused on the development of plastic nano titer plates for applications in high throughput screening (HTS). For screening systems with integrated confocal microscopes plastic chips have been fabricated by injection molding and injection compression molding which contain micro wells with volumes of 0.9 μl and 1.4 μl and bottom plates with thicknesses of 120 μm and 200 μm. In addition, plastic chips with through holes have been joined with 160 μm glass plates by an adhesive printing process. First fluorescence correlation spectroscopy (FCS) measurements show that the plastic plates with glass bottoms are qualified as screening grade FCS nano titer plates.

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Authors and Affiliations

  1. Institut für Mikrotechnik Mainz GmbH, Carl-Zeiss-Str. 18–20, D-55129 Mainz, Germany, , , , , , DE

    M. Niggemann, W. Ehrfeld & L. Weber

  2. Evotec BioSystems AG, Schnackenburgallee 114, D-22525 Hamburg, Germany, , , , , , DE

    R. Günther & O. Sollböhmer

Authors
  1. M. Niggemann
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  2. W. Ehrfeld
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  3. L. Weber
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  4. R. Günther
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  5. O. Sollböhmer
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Received: 15 May 1999 / Accepted: 19 May 1999

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Niggemann, M., Ehrfeld, W., Weber, L. et al. Miniaturized plastic micro plates for applications in HTS. Microsystem Technologies 6, 48–53 (1999). https://doi.org/10.1007/s005420050174

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  • DOI: https://doi.org/10.1007/s005420050174

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