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  • 1980-1984  (81)
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  • 1
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    Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-10
    Description: The gene for the circumsporozoite (CS) protein of Plasmodium falciparum has been cloned and its nucleotide sequence determined. The gene encodes a protein of 412 amino acids as deduced from the nucleotide sequence. The protein contains 41 tandem repeats of a tetrapeptide, 37 of which are Asn-Ala-Asn-Pro and four of which are Asn-Val-Asp-Pro. Monoclonal antibodies against the CS protein of Plasmodium falciparum were inhibited from binding to the protein by synthetic peptides of the repeat sequence. The CS protein of Plasmodium falciparum and the CS protein of a simian malaria parasite, Plasmodium knowlesi, have two regions of homology, one of which is present on either side of the repeat. One region contains 12 of 13 identical amino acids. Within the nucleotide sequence of this region, 25 of 27 nucleotides are conserved. The conservation of these regions in parasites widely separated in evolution suggests that they may have a function such as binding to liver cells and may represent an invariant target for immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dame, J B -- Williams, J L -- McCutchan, T F -- Weber, J L -- Wirtz, R A -- Hockmeyer, W T -- Maloy, W L -- Haynes, J D -- Schneider, I -- Roberts, D -- New York, N.Y. -- Science. 1984 Aug 10;225(4662):593-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6204383" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antibodies, Monoclonal/immunology ; Antigens, Surface/*genetics/immunology ; Base Sequence ; Epitopes/genetics ; *Genes ; Humans ; Liver/parasitology ; Malaria/*immunology ; Plasmodium/genetics ; Plasmodium falciparum/*genetics/immunology ; *Protozoan Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Albumin and Australian frogs: molecular data a challenge to speciation model (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: Vertebrate speciation in the southwest of Australia has long been viewed as resulting from multiple invasions of eastern source stocks during the Pleistocene. Microcomplement fixation studies of serum albumin evolution in frogs of the genus Heleioporus provide the first hard data on age and phylogenetic relationships among species in this genus and lead to rejection of the multiple invasion model in favor of speciation occurring in Western Australia. The albumin molecular clock was used to estimate that the species divergences in this genus occurred between 4 million to 12 million years ago in the late Tertiary (Pliocene-Miocene), rather than in the Quaternary (the last 2 million years).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maxson, L R -- Roberts, J D -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):957-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17779867" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Ownership of computer program (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, J D -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):110-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17769189" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Drosophila larval fat body surfaces (1983)
    Springer
    Development genes and evolution 192 (1983), S. 1-7 
    Details
    ISSN: 1432-041X
    Keywords: Fat body ; Basement membrane ; Ageing ; Transplantation ; Monoclonal antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The hemocytes oftu-Sz ts melanotic tumor larvae ofDrosophila melanogaster encapsulate heterospecific and surface-modified homospecific tissue implants, but do not encapsulate unmodified homospecific implants (R. Rizki and Rizki 1980). In the present study we usedtu-Sz ts hosts to assay changes in larval fat body surfaces during development. Donor fat bodies from various ages of larvae were accepted (remained unencapsulated) intu-Sz ts hosts whereas fat bodies from donors with everted spiracles and all subsequent stages of development that were tested were rejected (encapsulated). Since the demarcation between acceptance and rejection by thetu-Sz ts blood cells did not coincide with the gross morphological changes that appear in the fat body during metamorphosis (dissolution of the basement membrane and dispersal of the freed fat body cells at pupation), we compared acceptable and nonacceptable fat body surfaces by three other methods. Fat body surface ultrastructure was examined, fat bodies were treated with fluorescein isothiocyanate-conjugated lectins, and fat body surfaces were reacted with a monoclonal antibody specific for basement membrane. These approaches did not uncover fat body surface changes associated with eversion of the anterior spiracles, suggesting that recognition of tissue surface heterogeneities by the insect hemocytes exceeds the resolving power of the other three methods. However, the monoclonal antibody fails to bind to the basement membrane ofD. virilis larvae, whose fat body is always rejected intu-Sz ts hosts. This supports our suggestion that the molecular architecture of the basement membrane may be important in eliciting the encapsulation response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848762
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  • 5
    Electronic Resource
    Electronic Resource
    Growth and reproductive rates of Littorina rudis from three contrasted shores in North Wales, UK (1980)
    Springer
    Marine biology 58 (1980), S. 47-54 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Data are presented on growth and reproductive rates of Littorina rudis Maton from 3 contrasted habitats: a sheltered saltmarsh, a moderately sheltered boulder shore and an exposed cliff face. Growth was fastest in L. rudis from the moderately sheltered boulder shore, followed closely by snails from the sheltered saltmarsh. Growth was much slower and the asymptotic size much less in L. rudis from the exposed cliff face, this being attributed to the reduced time available for foraging caused by longer and more erratic periods when the substratum dries out. Eggs extracted from the brood chambers of the saltmarsh L. rudis took about 72 d to hatch in the laboratory at 10°C. No seasonal trend was detected in the percentage of sexually mature snails, which fluctuated erratically round about 54 to 99% in each population. Similarly, the ratio of females: males fluctuated erratically about 1.0. The number of eggs and embryos held in the brood chamber peaked in May–June and birth rates (release of young from the brood chamber) peaked in July-August. Following a lull in August, the brood chamber contents were maintained at moderately high levels throughout the winter, whereas the birth rates declined to very low levels. These differences in the seasonal cycle of brood chamber contents and birth rates were probably caused by seasonal differences in embryological development rate and in the propensity of the young to leave the brood chamber. Fecundity increased with parental size and, because of this, the smaller, slower growing exposed-shore L. rudis had much lower potential fecundities than L. rudis from the other shores. However, the size-specific fecundity of the exposedshore L. rudis was about 1.7 times that of L. rudis on the more sheltered shores. This difference was apparently not attributable to smaller young or to a greater capacity of the brood chamber in the exposedshore L. rudis, and must therefore have been caused by higher rates of egg production. 18% of mature females from the boulder shore and 5% of those from the cliff face were oviparous, having a jelly gland in place of the brood chamber.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386879
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  • 6
    Electronic Resource
    Electronic Resource
    An empirical test of biases in the rapid visual technique for species-time censuses of reef fish assemblages (1982)
    Springer
    Marine biology 70 (1982), S. 129-134 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract For an assemblage of fishes inhabiting a warm temperate, rock reef near San Diego, California (USA), a series of censuses were made based on frequency of occurrence and standard numerical counts. These data were then compared with a parallel study based on the rapid visual technique (RVT) of Jones and Thompson (1978). Because the RVT ranks abundances according to frequency of encounter and disregards variations in the spatial distributions of different species, the method overemphasizes the importance of widespread albeit rare fishes but under-emphasizes patchy although abundant species. The discussion considers the relative merits of the RVT method for characterizing assemblages of fishes on temperate rock reefs and on tropical coral reefs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397676
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  • 7
    Electronic Resource
    Electronic Resource
    COELIAC DISEASE AND HLA: A FAMILY STUDY (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In a family study of coeliac disease, HLA types in fifty-three patients and their relatives were examined. There are no differences in HLA frequencies between child and adult patients. Comparison with a random series of normal controls shows increases frequencies in patients of HLA-A1 and B8, while the family material shows that there is also an excess of haplotype I-8. The excess of homozygotes is thought not to be a factor in the aetiology. Intrafamilial analysis shows that only B8 is significantly associated with the disorder. It is argued that the HLA association does not indicate a ‘coeliac gene’ but that the B8 allele is a major gene in a polygenic system affecting the disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00732.x
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  • 8
    Electronic Resource
    Electronic Resource
    Additions and Corrections - Orientation in Base-Promoted 1,2-Elimination Reactions. Nitrogen and Carbon Bases. (1980)
    s.l. : American Chemical Society
    The @journal of organic chemistry 45 (1980), S. 5433-5433 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01314a612
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  • 9
    Electronic Resource
    Electronic Resource
    RESPRO-an interactive procedure for planning newproduct chemical research (1981)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 11 (1981), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The model has been developed specifically for the great uncertainties obtaining in new-product chemical researchparticularly in the pharmaceutical industry-but it is hoped that it will prove flexible enough to be used in other circumstances. The program is in Fortran and could be run on most computer systems.Procedures for selecting projects and reviewing their progress are becoming increasingly important aspects of R & D management. Modelling a procedure mathematically can prove advantageous, especially if such a model is capable of computational analysis, for then the policy alternatives can easily be explored and compared. This paper describes one such computer based procedure. In quantifying the value of any effort allocation, the program automatically takes account of the fact that estimates of the likelihood that a project will result in a new discovery change as work continues on the project. It also computes a marginal profitability index for each project. Comparison of these indices suggests ways in which effort might profitably be re-allocated among projects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1981.tb00471.x
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  • 10
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    Applications of Polymorphisms in Anthropogenetic Studies (1982)
    Baltimore : Periodicals Archive Online (PAO)
    Human Biology. 54:2 (1982:May) 175 
    Details
    ISSN: 0018-7143
    Topics: Biology
    Notes: Salute to Gabriel Ward Lasker
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5243-1982-054-02-000003
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