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Inhibition by idrocilamide of the disposition of caffeine (1980)

Brazier, J. L. ; Descotes, J. ; Lery, N. ; [et al.]

Springer

European journal of clinical pharmacology 17 (1980), S. 37-43

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ISSN: 1432-1041

Keywords: caffeine ; idrocilamide ; xanthine derivatives ; inhibition of metabolism ; neuropsychiatric side effects ; pharmacokinetics ; healthy man

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00561675

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