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  • 1985-1989  (3)
  • 1
    Electronic Resource
    Electronic Resource
    A ready-to-use activated charcoal mixture (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 56-60 
    Details
    ISSN: 1573-739X
    Keywords: Adsorption capacity ; Charcoal, activated ; Clearance enhancement ; Paracetamol ; Poisoning ; Theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A practical, ready-to-use preparation of activated charcoal (AZU mixture) for application in toxicology has been formulated. Tb establish its efficacy, the formulation was testedin vitro and in dogs. Thein vitro adsorption capacity was compared to that of freshly prepared charcoal suspension in water (CW) and to Carbomix®. Langmuir adsorption coefficients demonstrated small but clinically insignificant differences in adsorption capacity between the preparations. The laxative sodium sulfate did not reduce the adsorption capacity of charcoalin vitro. Dogs were given 60 mg of paracetamol per kg as an oral solution followed by 5 g of activated charcoal preparation. The area under the plasma concentration versus time curve (control 2955±353 mg·min−1·1−1) was significantly reduced following CW (921±453) and AZU (786±270). The premixed AZU charcoal formulation is efficacious, inexpensive and overcomes the problems of bed-side preparation. An isolated vascularly perfused rat small intestine can be used to describe the effect of activated charcoal on the intestinal secretion of theophylline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01962976
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  • 2
    Electronic Resource
    Electronic Resource
    A general system for the automation of a backflush equipped gas chromatograph and its application in the determination of fluoride in plasma and faeces (1985)
    Springer
    Pharmacy world & science 7 (1985), S. 117-120 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A fully automated system is described in which a gas chromatograph equipped with a backflush valve is automatically operated under the control of a specially designed timer unit. The system requires minimum data acquisition due to the selection of the signals to be integrated while waste of recorder paper is also avoided. It has the capability of unattended operation of fifty samples which — in the case of fluoride determination — are chromatographed in about four hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968713
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of a single dose of ofloxacin in healthy elderly subjects using noncompartmental and compartmental models (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 224-228 
    Details
    ISSN: 1573-739X
    Keywords: Absorption ; Aged ; Clearance, renal ; Models, theoretical ; Ofloxacin ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of ofloxacin following a single 200 mg oral dose were studied in twelve healthy elderly volunteers. Relevant pharmacokinetic parameters were analysed by both noncompartmental and compartmental models. In compartmental analysis, the data on plasma concentrations was best described by an open two-compartment model. A zero-order absorption behaviour was found in some volunteers. The terminal half-lives were slightly prolonged and ranged from 6.2–11.6 h. A linear relationship was found between the renal clearance of the drug and the estimated creatinine clearance. Computer predictions of a multiple 200 mg dose regimen showed no important accumulation of ofloxacin. The recommendation of some authors that, in general, ofloxacin dosage may be halved in the elderly could not be confirmed. This has to be determined through further clinical experience in elderly ill subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959415
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