ISSN:
1432-1041
Keywords:
methyl salicylate
;
skin absorption
;
exercise
;
heat exposure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effects of exercise, heat exposure or both on the percutaneous absorption of methyl salicylate were studied in 6 healthy volunteers. Exercise was performed to 30% ofVO2max, 45 min each hour for 6 h, at ambient temperatures of 22°C or 40°C. Systemic availability was assessed by measurement of plasma salicylate concentrations and cumulative urinary salicyluric acid excretion over an 8-h collection period. The absorption of methyl salicylate was increased to more than 3-times above control in subjects exercising in the heat. It is concluded that exercise and heat exposure, by increasing skin temperature, hydration and blood flow, enhance the percutaneous absorption of methyl salicylate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00870985
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