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  • 1
    Electronic Resource
    Electronic Resource
    N-(2-Cyanoethyl)tranylcypromine, a Potential Prodrug of Tranylcypromine: Its Disposition and Interaction with Catecholamine Neurotransmitters in Brain (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 16-20 
    Details
    ISSN: 1573-904X
    Keywords: monoamine oxidase inhibitors ; tranylcypromine ; N-(2-cyanoethyl)tranylcypromine ; catecholamines ; brain ; prodrug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The disposition of the N-cyanoethyl analogue of tranylcypromine (TCP) and the TCP formed from it have been studied in the rat brain following intraperitoneal (ip) administration (0.1 mmol/kg) and the resultant data compared with those obtained following an equimolar dose of TCP. Brain concentrations of the neurotransmitter amines dopamine (DA) and noradrenaline (NA) have also been determined, as well as the percentage inhibition of monoamine oxidase (MAO) types A and B. Our results indicate that the N-cyanoethyl analogue may be a useful prodrug of TCP, providing lower but more sustained concentrations of TCP in brain. Brain levels of DA were increased in a similar pattern after CE-TCP or TCP. Brain levels of NA were decreased by TCP at most time intervals, while CE-TCP produced a much less pronounced effect. Both CE-TCP and TCP inhibited MAO-A and MAO-B, with maximum inhibition occurring 60 min after CE-TCP dosing and 30 min after dosing with TCP, times at which brain concentrations of CE-TCP and TCP were at the maximum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016417624741
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  • 2
    Electronic Resource
    Electronic Resource
    Separation-bubble flow solution using Euler/Navier-Stokes zonal approach with downstream compatibility conditions (1988)
    Springer
    Journal of scientific computing 3 (1988), S. 121-137 
    Details
    ISSN: 1573-7691
    Keywords: Computational fluid dynamics ; compressible Navier-Stokes equations ; zonal method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract An Euler/Navier-Stokes zonal scheme is developed to numerically simulate the two-dimensional flow over a blunt leading-edge plate. The computational domain has been divided into inner and outer regions where the Navier-Stokes and Euler equations are used, respectively. On the downstream boundary, compatibility conditions derived from the boundary-layer equations are used. The grid is generated by using conformal mapping and the problem is solved by using a compressible Navier-Stokes code, which has been modified to treat Euler and Navier-Stokes regions. The accuracy of the solution is determined by the reattachment location. Bench-mark solutions have been obtained using the Navier-Stokes equations throughout the optimum computational domain and size. The problem is recalculated with sucessive decrease of the computational domain from the downstream side where the compatibility conditions are used, and with successive decrease of the Navier-Stokes computational region. The results of the zonal scheme are in excellent agreement with those of the benchmark solutions and the experimental data. The CPU time saving is about 15%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061253
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  • 3
    Electronic Resource
    Electronic Resource
    Survivorship, potential, and realized fecundity ofBiosteres tryoni [Hymenoptera: Braconidae], a larval parasitoid ofCeratitis capitata [Diptera: Tephritidae] (1989)
    Springer
    BioControl 34 (1989), S. 291-297 
    Details
    ISSN: 1573-8248
    Keywords: Biosteres tryoni ; Ceratitis capitata ; survivorship potential fecundity ; realized fecundity ; Biosteres tryoni ; Ceratitis capitata ; survie ; fécondité potentielle ; fécondité réelle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé LesBiosteres tryoni élevés en laboratoire atteignaient le sommet de leur maturation ovarienne le 5e jour après l'émergence chez les ♀♀ vierges et le 7e jour chez les ♀♀ accouplées. Quand il n'était pas permis aux ♀♀ de pondre, le contenu des oocytes était hydrolysé et réabsorbé. Cependant, quand des hôtes étaient disponibles pour la ponte, on notait une augmentation significative du taux de maturation des œufs. La moyenne de la fécondité réalisée durant la vie était 71,7±8,1 et 69,0±6,7 et la longévité moyenne était 13,5±0,9 et 15,1±0,6 jours pour les ♀♀ accouplées et les ♀♀ vierges respectivement.
    Notes: Abstract Laboratory-rearedBiosteres tryoni (Cameron) reached peak ovarian maturation on the 5th and 7th days after emergence in unmated and mated ♀♀, respectively. When ♀♀ were not allowed to oviposit, contents of the oocytes were hydrolyzed and reabsorbed. However, when hosts were available for oviposition a significant increase of egg maturation rate was noticed. Mean realized fecundity during the life span was 71.7±8.1 and 69.0±6.7, and mean longevity was 13.5±0.9 and 15.1±0.6 days for mated and unmated ♀♀ respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02372468
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