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  • 1985-1989  (59)
  • 1960-1964  (9)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Oscillations and complex mechanisms: O2 oxidation of benzaldehyde (1987)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 4207-4217 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00248a014
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  • 2
    Electronic Resource
    Electronic Resource
    Immediate central and regional haemodynamic effects of a new beta1-adrenergic stimulating drug, xamoterol (Corwin) in healthy volunteers (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 155-158 
    Details
    ISSN: 1432-1041
    Keywords: xamoterol ; beta-adrenoceptor agonist ; intrinsic sympathomimetic activity ; forearm blood flow ; systolic time intervals ; haemadynamic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Dose-response curves for heart rate, arterial blood pressure, cardiac output, total peripheral resistance, systolic time intervals, forearm blood flow and forearm vascular resistance were obtained after i.v. administration of seven logarithmically increasing doses of xamoterol to 8 healthy volunteers. The total cumulative dose was 0.2 mg/kg b.w. At rest after the seventh dose of xamoterol heart rate, systolic blood, pressure, cardiac output and forearm blood flow were increased by 10%, 20%, 23% and 41%, respectively. Diastolic blood pressure was unchanged. Forearm vascular resistance was reduced by 21% and total peripheral resistance by 10%. Systolic time intervals were reduced: total electromechanical systole index (QS2I), left ventricular ejection time index (LVETI), pre ejection period index (PEPI) and PEP/LVET ratio by 4%, 2%, 12% and 14%, respectively. No side-effects were observed. During upright exercise after the seventh dose of xamoterol heart rate was reduced by 11% and systolic BP by 6%. Diastolic blood pressure was unchanged. Thus xamoterol increased the contractility of the heart with only a small increase in heart rate, increased systolic blood pressure and caused vasodilatation in resting skeletal muscle. During exercise the reduction in heart rate and blood pressure suggests beta-adrenoceptor blocking activity of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547414
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  • 3
    Electronic Resource
    Electronic Resource
    Haemodynamic effects of atenolol, pindolol and propranolol during adrenaline infusion in man (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 659-663 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; pindolol ; propranolol ; beta-receptor blocking drugs ; beta1-selectivity ; intrinsic sympathomimetic activity ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind, cross over study the haemodynamic effects of an i.v. infusion of adrenaline during concomitant administration of atenolol, pindolol, propranolol or placebo were examined in 7 healthy volunteers. During coadministration with placebo, adrenaline caused an increase in systolic blood pressure (SBP) of 26 mm Hg and a decrease in diastolic blood pressure (DBP) of 20 mm Hg. Heart rate (HR) and stroke volume (SV) were increased by about 20–30%. Total peripheral resistance (TPR) fell significantly. When the subjects were pretreated with atenolol, the adrenaline increased SBP by 16 mm Hg, the DBP did not change, HR and SV increased by 19 and 30%, and TPR fell. During concomitant administration of the non-selective betablocker pindolol, which has strong intrinsic sympathomimetic activity (ISA), adrenaline increased SBP by 11 mm Hg and DBP by 17 mm Hg. This pure pressor response led to a significant reduction in HR and SV and an increase in TPR, probably mediated through the baroreceptors. The haemodynamic response to adrenaline during coadministration of propranolol was very similar to that seen after pindolol. It is concluded that a beta1-selective blocker interferes very little with the haemodynamic response to adrenaline, whereas it is changed to a pure pressor response during coadministration of a non-selective betablockers. ISA did not significantly modify the pressor response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608212
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of metoprolol and propranolol on platelet aggregation and cAMP level in hypertensive patients (1986)
    Springer
    European journal of clinical pharmacology 29 (1986), S. 561-564 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; beta-adrenoceptor blockers platelet aggregation ; cyclic-AMP ; metoprolol ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with uncomplicated moderate essential hypertension were recruited to evaluate the effect of the non-selective beta-blocker propranolol and the beta1-selective beta-blocker metoprolol on platelet aggregation and cAMP formation. Five patients began treatment with propranolol 80 mg b. i. d. and 5 with metoprolol 100 mg b. i. d., and after 2 weeks the treatments were exchanged. ADP- and adrenaline-induced platelet aggregation and the basal level of platelet cAMP were measured at the end of each treatment period. Platelet aggregation was tested turbidometrically, using the threshold value for irreversible aggregation, and cAMP measurements were performed using a protein-binding assay. Both ADP and adrenaline thrshold values were significantly lower after propranolol than after metoprolol. The basal cAMP level was lower during propranolol than metoprolol treatment. The results indicate that platelet aggregation and basal cAMP level are influenced by beta-blockers in proportion to their affinity to different beta-adrenoceptors. This may be of value in the beta-blocker treatment of patients at high thrombotic risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635893
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of three beta-blockers with different pharmacodynamic properties on platelet aggregation and platelet and plasma cyclic AMP (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 17-20 
    Details
    ISSN: 1432-1041
    Keywords: beta-adrenoceptor blockade ; platelet aggregation ; intrinsic sympathomimetic activity ; plasma cyclic AMP ; mild hypertension ; platelet cAMP ; pindolol ; metoprolol ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of three different types of beta-adrenoceptor blocking agents on platelet aggregation and on platelet and plasma cyclic AMP content have been studied in 14 patients with mild hypertension given each drug in turn for two weeks. The drugs were a non-selective blocking agent with high intrinsic sympathomimetic activity, pindolol, the nonspecific blocking agent propranolol, and the beta1-selective metoprolol. The threshold values of ADP and adrenaline for irreversible platelet aggregation were significantly higher for pindolol and metoprolol than for propranolol. The cyclic AMP content of platelets was higher during pindolol and metoprolol than during propranolol treatment. Pindolol produced a substantial increase in plasma cyclic AMP relative to the other two drugs. Thus, platelet aggregation and cyclic AMP formation are influenced by beta-adrenoceptor blockade in proportion to intrinsic sympathomimetic activity and affinity for different beta-adrenoceptor subtypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555501
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  • 6
    Electronic Resource
    Electronic Resource
    Haemodynamic effects and kinetics of concomitant intravenous disopyramide and atenolol in patients with ischaemic heart disease (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 161-166 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; atenolol ; pharmacodynamics ; ischaemic heart disease ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectively and the heart rate (HR) and preejection period index (PEPI) increased by 13% and 19%, respectively. A decrease in CI of 14% and HR of 21%, respectively were noted after intravenous administration of 7.5 mg atenolol; PEPI increased by 10% whereas SVI remained unchanged. The cardiac Index (CI) fell by 33% following the administration of both drugs. The effect on CI of the two drugs was additive. The effect of disopyramide and atenolol on HR, SVI and PEPI was not significantly modified by coadministration of the other drug. No change in blood pressure was observed after disopyramide or atenolol. A correlation (ρ) of 0.540 and 0.387 was observed between the change in PEPI and the log free and total serum concentrations of disopyramide, respectively. Combined intravenous use of the two drugs in patients with incipient or overt heart failure is not recommended, unless it is due to the arrhythmia to be treated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614295
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  • 7
    Electronic Resource
    Electronic Resource
    Antipyrine metabolism is not affected by terbinafine, a new antifungal agent (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 231-233 
    Details
    ISSN: 1432-1041
    Keywords: antipyrine ; terbinafine ; drug metabolism ; drug interaction ; enzyme induction/inhibition ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The potential to inhibit drug metabolism of the new antifungal agent terbinafine has been studied using antipyrine (single oral dose of 10 mg/kg) as a probe drug. In a cross-over study in 8 healthy volunteers, antipyrine was administered prior to, during and after 8 days of oral terbinafine 125 mg b.d. Antipyrine, its major metabolites 4-hydroxyantipyrine (4-OH-AP), 3-hydroxymethylantipyrine (3-OH-CH3-AP) and norantipyrine (Nor-AP) were analyzed by specific HPLC assays in multiple plasma and urine samples. During all three parts of the study, the pharmacokinetics of antipyrine viz. t1/2 (11.7 h), total plasma (38.5 ml·h−1·kg−1) and renal clearance (1.6 ml·h−1·kg−1), and its clearance rates to metabolites (CLM), eg. CLM for 4-OH-AP (12.3 ml·h−1·kg−1), CLM for 3-OH-CH3-AP (4.2 ml·h−1·kg−1) and CLM for Nor-AP (6.7 ml·h−1·kg−1) did not differ from the control values. Thus, all the cytochrome P-450-dependent isozymes involved in the metabolism of antipyrine and many other drugs should not be affected by therapeutic doses of terbinafine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00679775
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  • 8
    Electronic Resource
    Electronic Resource
    EPR oscillations during oxidation of benzaldehyde (1987)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 91 (1987), S. 3380-3382 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100296a055
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  • 9
    Electronic Resource
    Electronic Resource
    Gillnet selectivity and the efficiency of alternative combinations of mesh sizes for some freshwater fish (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 28 (1986), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The selectivity curves of nylon gillnets for burbot and two groups of Arctic charr of different fatness were found by the Gulland-Harding method. They are compared to the selectivity curves of whitefish, brown trout, and perch. Based upon these curves and the relationships between most efficient mesh size and fish length, the pooled relative efficiency of a geometrical and an arithmetical series of mesh sizes was calculated for salmonids, burbot, and perch. This efficiency of the geometrical series is different for the three groups of fish, but equal for each group over the interval between the modal lengths of the smallest and largest mesh sizes. The efficiency of the arithmetical series is also different for the three groups, increases linearly with fish length, and is valid over the interval between the modal lengths of the second smallest and the second largest mesh sizes. Each series has its special advantages, and both are easily adjusted to the fish length interval of interest. They are especially adapted for the catch of salmonids. For these, the variations of condition factor is more important than any characteristics of the species, and its influence upon the most efficient mesh size to fish length relationship and the pooled relative efficiency of the two series of nets is evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1986.tb05198.x
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of Mitochondrial Inhibitors on Intraerythrocytic Plasmodium falciparum in In Vitro Cultures (1986)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 33 (1986), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: . Malarial parasites infecting mammalian hosts are considered to be homolactate fermentors at their asexual intraerythrocytic developmental stage; however, existing ultrastructural and biochemical evidence suggest that their acristate mitochondria could be involved in energy metabolism. In the present study, inhibitors of mitochondrial function including compounds which act on NADH and succinate dehydrogenases, electron transport and mitochondrial ATPase, as well as uncouplers, were found to inhibit the growth and propagation of the human parasite Plasmodium falciparum in in vitro cultures at concentrations that specifically affect mitochondrial functions. Direct measurement of parasite protein and nucleic acid synthesis in synchronized cultures showed that throughout the parasite life cycle both processes were inhibited, the latter process being more sensitive. These results strongly suggest that intraerythrocytic malarial parasites require mitochondrial energy production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1986.tb05570.x
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