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  • 1
    Electronic Resource
    Electronic Resource
    Lack of interaction of ketoprofen with warfarin (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 205-206 
    Details
    ISSN: 1432-1041
    Keywords: Warfarin ; Ketoprofen ; non-steroidal anti inflammatory drugs ; drug interaction ; platelets ; coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We gave ketoprofen (100 mg bid) for 7 days, on a placebo-controlled, double-blind basis, to 15 healthy male volunteers already stabilized on warfarin in dosages which lowered the prothrombin time by about 60%. Ketoprofen did not affect the prothrombin time, there was no change in coagulation cascade parameters, and there was no clinical evidence of bleeding. We conclude that ketoprofen in this dosage has no significance effect on the anticoagulant effect of warfarin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315483
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of timolol and metoprolol on platelet function at rest and during exercise (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 587-592 
    Details
    ISSN: 1432-1041
    Keywords: timolol ; metoprolol ; platelet aggregation ; platelet count ; cyclic AMP ; beta-adrenoceptor blocking agents ; exercise ; thromboxane B2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten male patients suffering from stable angina pectoris were studied at rest and immediately after exercise during treatment either with timolol (a non-selective beta-blocker) or with metoprolol (a beta1-selective blocker). Timolol induced a significant increase in platelet aggregation and a reduction in platelet cyclic AMP, and it also raised the plasma adrenaline at rest and during exercise as compared to the pre-treatment level. Metoprolol had none of these effects. Prior to medication and during metoprolol treatment, exercise led to an increase in the peripheral platelet count, whereas timolol was associated with a reduction of platelets during physical effort. Neither drug affected platelet thromboxane B2 at rest. During exercise, its level was not affected in the pre-treatment period or during metoprolol treatment but it was sharply increased by timolol therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542492
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of metoprolol and propranolol on platelet aggregation and cAMP level in hypertensive patients (1986)
    Springer
    European journal of clinical pharmacology 29 (1986), S. 561-564 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; beta-adrenoceptor blockers platelet aggregation ; cyclic-AMP ; metoprolol ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with uncomplicated moderate essential hypertension were recruited to evaluate the effect of the non-selective beta-blocker propranolol and the beta1-selective beta-blocker metoprolol on platelet aggregation and cAMP formation. Five patients began treatment with propranolol 80 mg b. i. d. and 5 with metoprolol 100 mg b. i. d., and after 2 weeks the treatments were exchanged. ADP- and adrenaline-induced platelet aggregation and the basal level of platelet cAMP were measured at the end of each treatment period. Platelet aggregation was tested turbidometrically, using the threshold value for irreversible aggregation, and cAMP measurements were performed using a protein-binding assay. Both ADP and adrenaline thrshold values were significantly lower after propranolol than after metoprolol. The basal cAMP level was lower during propranolol than metoprolol treatment. The results indicate that platelet aggregation and basal cAMP level are influenced by beta-blockers in proportion to their affinity to different beta-adrenoceptors. This may be of value in the beta-blocker treatment of patients at high thrombotic risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635893
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of three beta-blockers with different pharmacodynamic properties on platelet aggregation and platelet and plasma cyclic AMP (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 17-20 
    Details
    ISSN: 1432-1041
    Keywords: beta-adrenoceptor blockade ; platelet aggregation ; intrinsic sympathomimetic activity ; plasma cyclic AMP ; mild hypertension ; platelet cAMP ; pindolol ; metoprolol ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of three different types of beta-adrenoceptor blocking agents on platelet aggregation and on platelet and plasma cyclic AMP content have been studied in 14 patients with mild hypertension given each drug in turn for two weeks. The drugs were a non-selective blocking agent with high intrinsic sympathomimetic activity, pindolol, the nonspecific blocking agent propranolol, and the beta1-selective metoprolol. The threshold values of ADP and adrenaline for irreversible platelet aggregation were significantly higher for pindolol and metoprolol than for propranolol. The cyclic AMP content of platelets was higher during pindolol and metoprolol than during propranolol treatment. Pindolol produced a substantial increase in plasma cyclic AMP relative to the other two drugs. Thus, platelet aggregation and cyclic AMP formation are influenced by beta-adrenoceptor blockade in proportion to intrinsic sympathomimetic activity and affinity for different beta-adrenoceptor subtypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555501
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of felodipine, a new calcium channel antagonist, on platelet function and fibrinolytic activity at rest and after exercise (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 453-457 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; calcium channel blockade ; exercise ; platelet function ; fibrinolytic activity ; platelet release ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fourteen healthy male volunteers (age 21–29 years, mean 23.7 years) were given placebo for 14 days followed immediately by felodipine 5 mg b.d. for a further 14 days. After each period of treatment blood for analysis was taken at rest and after exercise on a cycle ergometer. Platelet aggregation, plasma beta-thromboglobulin (B-TG), platelet factor 4 (PF-4), adrenaline and noradrenaline, and serum thromboxane B2 (TXB2), 6-keto-prostaglandin (F1α (6-keto-PGF1α), and euglobulin clot lysis time (ECLT), were measured on each occasion. The ECG, heart rate and blood pressure were monitored during the exercise tests. After felodipine therapy there was a significant decrease in the plasma level of PF-4 and B-TG at rest. This effect was maintained during exercise. There was no significant change in platelet aggregation, ECLT, TXB2 or 6-keto-PGF1α at rest or during exercise. Irrespective of therapy, the plasma levels of adrenaline and noradrenaline were increased and the ECLT was decreased when measured immediately after exercise. Thus, felodipine in modest therapeutic dosage decreases the plasma levels of B-TG and PF-4, indicating an inhibitory effect on platelet on release. The effect also occurred during exercise. Felodipine did not change fibrinolytic activity or the production of TXB2 or 6-keto-PGF1α.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558123
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  • 6
    Electronic Resource
    Electronic Resource
    Serotonin-induced platelet aggregation predicts the antihypertensive response to serotonin receptor antagonists (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 121-125 
    Details
    ISSN: 1432-1041
    Keywords: Hypertension ; Ketanserin ; platelet aggregation ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The 5-HT2-receptor antagonist ketanserin (20–40 mg b.i.d.) was administered to 62 patients of both sexes with uncomplicated primary hypertension. After 4 weeks of treatment about 50% of the patients had reached the target diastolic blood pressure of 90 mm Hg or below. Interindividual variability was large. In a retrospective analysis the variability could not be explained by sex or the dose of ketanserin. There was a weak association between age and systolic blood pressure response (r=0,24; P=0.06), which could be entirely accounted for by the higher base line blood pressure in the elderly patients. In one group of patients (n=12), the ex vivo aggregation to serotonin (10−6 M) was studied during treatment with placebo and ketanserin. Ketanserin completely inhibited 5-HT-induced aggregation in all patients. There was a close correlation between the area under the 5-HT-induced platelet aggregation curve during placebo and the subsequent reduction in diastolic blood pressure after 4 weeks of treatment with ketanserin. The present data suggest that the blood pressure response to ketanserin can be predicted from the ex vivo sensitivity of platelets to serotonin. By implication, they also support a role for serotonergic mechanisms in hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315468
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  • 7
    Electronic Resource
    Electronic Resource
    Lack of effect of 5-aminosalicylic acid on platelet aggregation and fibrinolytic activity in vivo and in vitro (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 419-422 
    Details
    ISSN: 1432-1041
    Keywords: 5-aminosalicylic acid (mesalazine) ; inflammatory bowel disease ; platelet aggregation ; fibrinolytic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied platelet aggregation and fibrinolytic activity in six patients with chronic inflammatory bowel disease treated with 5-aminosalicylic acid (mesalazine). There were no changes in these measurements during normal treatment, i.e. 1.5 g per day with a slow-release formulation, nor after an intravenous dose of 250 mg. Also in vitro tests were negative, in contrast to the inhibition seen with aspirin (acetylsalicylic acid). We conclude that treatment with mesalazine does not constitute a hazard to these patients in regard to prolonged bleeding time caused by an influence on platelet aggregation or fibrinolytic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637641
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  • 8
    Electronic Resource
    Electronic Resource
    Dose-dependent effects of verapamil and nifedipine on in vivo platelet function in normal volunteers (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 291-293 
    Details
    ISSN: 1432-1041
    Keywords: Platelet aggregation verapamil ; nifedipine ; platelet release products ; calcium channel blockers ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of 1 week of treatment with low and moderate doses of verapamil or nifedipine upon platelet function has been studied in 12 healthy volunteers. The ex vivo platelet aggregation threshold for ADP or adrenaline was not altered by verapamil or nifedipine. The plasma concentrations of β-thromboglobulin and platelet factor 4 were significantly reduced by low but not by moderate doses of verapamil and nifedipine. Low doses of verapamil and nifedipine inhibit in vivo platelet activity in healthy volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315114
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  • 9
    Electronic Resource
    Electronic Resource
    A model for estimating the composition of partial melts (1995)
    Springer
    Mineralogy and petrology 53 (1995), S. 189-195 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Ein Modell für die Abschätzung der Hauptelementzusammensetzung von Teilschmelzen jeder möglichen Zusammensetzung, die aus natürlichen Silikatgesteinen abgeleitet sind, wird vorgestellt. Bedingung ist, daß die Ursprungszusammensetzung und die physikalischen Bedingungen der Aufschmelzung bekannt sind. Ein weiteres Modell ermöglicht die Bestimmung der Wasserlöslichkeit in Silikatschmelzen. Diese Modelle sind einfache empirische Gleichungen, die auf einer Datenbasis von 1608 experimentellen Resultaten aus der Literatur beruhen. Die Ergebnisse können in der Planung von experimentellen Arbeiten, oder in der Interpretation von natürlichen Gesteinen dort benützt werden, wo genauere Methoden nicht verfügbar sind.
    Notes: Summary A model is presented for estimating the major element composition of almost any partial melt derived from natural silicate rocks, given that the source composition and physical conditions of melting are known. Another model allows the estimation of water solubility in silicate melts. These models are simple empirical equations based on a database of 1608 experimental results from the literature. The results can be used in the planning of future experimental work or for the interpretation of natural rocks when more accurate methods are not available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01171956
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  • 10
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    Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-18
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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