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  • 1
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    Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-29
    Description: Rasmussen's encephalitis is a progressive childhood disease of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the brain. During efforts to raise antibodies to recombinant glutamate receptors (GluRs), behaviors typical of seizures and histopathologic features mimicking Rasmussen's encephalitis were found in two rabbits immunized with GluR3 protein. A correlation was found between the presence of Rasmussen's encephalitis and serum antibodies to GluR3 detected by protein immunoblot analysis and by immunoreactivity to transfected cells expressing GluR3. Repeated plasma exchanges in one seriously ill child transiently reduced serum titers of GluR3 antibodies, decreased seizure frequency, and improved neurologic function. Thus, GluR3 is an autoantigen in Rasmussen's encephalitis, and an autoimmune process may underlie this disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rogers, S W -- Andrews, P I -- Gahring, L C -- Whisenand, T -- Cauley, K -- Crain, B -- Hughes, T E -- Heinemann, S F -- McNamara, J O -- NS17771/NS/NINDS NIH HHS/ -- NS28709/NS/NINDS NIH HHS/ -- NS30990R29/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Jul 29;265(5172):648-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Salt Lake City Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, UT.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8036512" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Autoantibodies/blood/*immunology ; Brain/pathology ; Cell Line ; Child ; Disease Models, Animal ; Encephalitis/complications/*immunology/pathology/therapy ; Female ; Humans ; Male ; Plasma Exchange ; Rabbits ; Receptors, Glutamate/*immunology ; Recombinant Fusion Proteins/immunology ; Seizures/etiology/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    An experimental study of inbreeding depression in a natural habitat (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-10-14
    Description: Inbreeding is known to lead to decreased survival and reproduction in captive populations of animals. It is also important to know whether inbreeding has deleterious effects in natural habitats. An estimate was made of the effects of inbreeding in white-footed mice, Peromyscus leucopus noveboracensis, derived from a wild population. This study demonstrates that inbreeding had a significant detrimental effect on the survivorship of mice reintroduced into a natural habitat. This effect was more severe than the effect observed in laboratory studies of the population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jimenez, J A -- Hughes, K A -- Alaks, G -- Graham, L -- Lacy, R C -- New York, N.Y. -- Science. 1994 Oct 14;266(5183):271-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Illinois-Chicago 60680.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7939661" target="_blank"〉PubMed〈/a〉
    Keywords: Analysis of Variance ; Animals ; Body Weight ; Female ; *Inbreeding ; Likelihood Functions ; Male ; Peromyscus/genetics/*physiology ; Regression Analysis ; Survival Rate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Application of the Galerkin/least-squares formulation to the analysis of hypersonic flows. I - Flow over a two-dimensional ramp (1991)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: An FEM for the compressible Navier-Stokes equations is introduced. The discretization is based on entropy variables. The methodology is developed within the framework of a Galerkin/least-squares formulation to which a discontinuity-capturing operator is added. Results for three test cases selected among those of the Workshop on Hypersonic Flows for Reentry Problems are presented.
    Keywords: AERODYNAMICS
    Type: In: Hypersonic flows for reentry problems. Vol. 2 (A93-42576 17-02); p. 181-200.
    Format: text
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  • 4
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    Application of the Galerkin/least-squares formulation to the analysis of hypersonic flows. II - Flow past a double ellipse (1991)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: A finite element method for the compressible Navier-Stokes equations is introduced. The discretization is based on entropy variables. The methodology is developed within the framework of a Galerkin/least-squares formulation to which a discontinuity-capturing operator is added. Results for four test cases selected among those of the Workshop on Hypersonic Flows for Reentry Problems are presented.
    Keywords: AERODYNAMICS
    Type: In: Hypersonic flows for reentry problems. Vol. 2 (A93-42576 17-02); p. 427-450.
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  • 5
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    Flow analysis for the nacelle of an advanced ducted propeller at high angle-of-attack and at cruise with boundary layer control (1994)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: An axisymmetric panel code and a three dimensional Navier-Stokes code (used as an inviscid Euler code) were verified for low speed, high angle of attack flow conditions. A three dimensional Navier-Stokes code (used as an inviscid code), and an axisymmetric Navier-Stokes code (used as both viscous and inviscid code) were also assessed for high Mach number cruise conditions. The boundary layer calculations were made by using the results from the panel code or Euler calculation. The panel method can predict the internal surface pressure distributions very well if no shock exists. However, only Euler and Navier-Stokes calculations can provide a good prediction of the surface static pressure distribution including the pressure rise across the shock. Because of the high CPU time required for a three dimensional Navier-Stokes calculation, only the axisymmetric Navier-Stokes calculation was considered at cruise conditions. The use of suction and tangential blowing boundary layer control to eliminate the flow separation on the internal surface was demonstrated for low free stream Mach number and high angle of attack cases. The calculation also shows that transition from laminar flow to turbulent flow on the external cowl surface can be delayed by using suction boundary layer control at cruise flow conditions. The results were compared with experimental data where possible.
    Keywords: AERODYNAMICS
    Type: NASA-TM-106371 , AIAA PAPER 94-0391 , E-8181 , NAS 1.15:106371 , Aerospace Sciences Meeting and Exhibit; Jan 10, 1994 - Jan 13, 1994; Reno, NV; United States
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  • 6
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    Further development and flight test of an autonomous precision landing system using a parafoil (1994)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: NASA Dryden Flight Research Center and NASA Johnson Space Center are jointly conducting a phased program to determine the feasibility of the autonomous recovery of a spacecraft using a ram-air parafoil system for the final stages of entry from space to a precision landing. The feasibility is being studied using a flight model of a spacecraft in the generic shape of a flattened biconic that weighs approximately 120 lb and is flown under a commercially available ram-air parafoil. Key components of the vehicle include the global positioning system (GPS) guidance for navigation, a flight control computer, an electronic compass, a yaw rate gyro, and an onboard data recorder. A flight test program is being used to develop and refine the vehicle. The primary flight goal is to demonstrate autonomous flight from an altitude of 3,000 m (10,000 ft) with a lateral offset of 1.6 km (1.0 mi) to a precision soft landing. This paper summarizes the progress to date. Much of the navigation system has been tested, including a heading tracker that was developed using parameter estimation techniques and a complementary filter. The autoland portion of the autopilot is still in development. The feasibility of conducting the flare maneuver without servoactuators was investigated as a means of significantly reducing the servoactuator rate and load requirements.
    Keywords: AERODYNAMICS
    Type: NASA-TM-4599 , H-1987 , NAS 1.15:4599 , AIAA PAPER 94-2141 , Biennial Flight Test Conference; Jun 20, 1994 - Jun 23, 1994; Colorado Springs, CO; United States
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  • 7
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    A new finite element formulation for computational fluid dynamics. X - The compressible Euler and Navier-Stokes equations (1991)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: A space-time element method is presented for solving the compressible Euler and Navier-Stokes equations. The proposed formulation includes the variational equation, predictor multi-corrector algorithms and boundary conditions. The variational equation is based on the time-discontinuous Galerkin method, in which the physical entropy variables are employed. A least-squares operator and a discontinuity-capturing operator are added, resulting in a high-order accurate and unconditionally stable method. Implicit/explicit predictor multi-corrector algorithms, applicable to steady as well as unsteady problems, are presented; techniques are developed to enhance their efficiency. Implementation of boundary conditions is addressed; in particular, a technique is introduced to satisfy nonlinear essential boundary conditions, and a consistent method is presented to calculate boundary fluxes. Numerical results are presented to demonstrate the performance of the method.
    Keywords: AERODYNAMICS
    Type: Computer Methods in Applied Mechanics and Engineering (ISSN 0045-7825); 89; 3-Jan; 141-219
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  • 8
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    Symmetrization of conservation laws with entropy for high-temperature hypersonic computations (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Results of Hughes, France, and Mallet are generalized to conservation law systems taking into account high-temperature effects. Symmetric forms of different equation sets are derived in terms of entropy variables. First, the case of a general divariant gas is studied; it can be specialized to the usual Navier-Stokes equations, as well as to situations where the gas is vibrationally excited, and undergoes equilibrium chemical reactions. The case of gas in thermochemical nonequilibrium is considered next. Transport phenomena, and in particular mass diffusion, are examined in the framework of symmetric advective-diffusive systems.
    Keywords: AERODYNAMICS
    Type: Computing Systems in Engineering (ISSN 0956-0521); 1; 4-Feb; 495-521
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