ISSN:
0009-2940
Keywords:
1-Oxa-3,5-diaza-1,3,5-hexatrienes
;
2H-1,3,5-Oxadiazines
;
1-Oxa-3,5-diaza-1,3,5-hexatriene - 2H-1,3,5-Oxadiazine tautomerism
;
Ring-chain tautomerism
;
Calculations, ab initio
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis and Structures of 1-Oxa-3,5-diaza-1,3,5-hexatrienes. The 1-Oxa-3,5-diaza-1,3,5-hexatriene/2H-1,3,5-Oxadiazine TautomerismReaction of N1-lithio-or N1-trimethylsilyl-substituted imines 1 with N1-acylimidic acid derivatives 2 provides 1-oxa-3,5-diaza-1,3,5-hexatrienes 3 in fair to good yields. Depending on the substitution pattern, the acyclic compounds 3 form an equilibrium with their cyclic tautomers, e.g. 2H-1,3,5-oxadiazines 4. Aromatic substituents at C-6 favor the acyclic form 3, whereas aliphatic groups (e.g. tert1-butyl) lead to the exclusive formation of the ring tautomer 4. For a typical example (3d/4d) the free enthalpy of activation for the ring/chain tautomerism was determined to be ca. 12.5 kcal/mol. Detailed spectroscopic data (1H-, 13C-NMR, IR, UV) for both tautomers are given. The X-Ray analysis of the acyclic compound 3a shows a central C=N bond with Z configuration and with s-gauche conformations of the adjacent C=O and C=N systems. According to quantum mechanical ab initio calculations (MP2/6-31G*/6-31G*) for the C3H4N2O model compounds, the ring tautomer 6 is by ca. 6 kcal/mol lower in energy than the acyclic forms 7. Within the series of open-chain tautomers 7, gauche forms are lower in energy than s-trans conformers, indicating that amide resonance is more important for these systems than polyene delocalization, s-cis Forms were found to be transition states. The acyclic conformers 7 are rather flexible; barriers of rotation for both C - N bonds are calculated to 4 - 5 kcal/mol only (RHF/ 3-21G/3-21G).
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19931260417
Permalink
