Publication Date:
1998-11-20
Description:
Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851625/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851625/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hensch, T K -- Fagiolini, M -- Mataga, N -- Stryker, M P -- Baekkeskov, S -- Kash, S F -- R37 EY002874/EY/NEI NIH HHS/ -- R37 EY002874-20/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 20;282(5393):1504-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. hensch@postman.riken.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9822384" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Diazepam/pharmacology
;
GABA Modulators/pharmacology
;
Gene Targeting
;
Glutamate Decarboxylase/genetics/*metabolism
;
Interneurons/*physiology
;
Long-Term Potentiation
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
*Neuronal Plasticity/drug effects
;
Photic Stimulation
;
Receptors, GABA-A/metabolism
;
Synaptic Transmission
;
Visual Cortex/cytology/metabolism/*physiology
;
Visual Pathways
;
gamma-Aminobutyric Acid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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