Publication Date:
1996-04-05
Description:
The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte "homing" process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial "decision processes" involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulated the homeostasis of immunologic resources are proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butcher, E C -- Picker, L J -- New York, N.Y. -- Science. 1996 Apr 5;272(5258):60-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, CA 94305-5324, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8600538" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens/immunology
;
B-Lymphocytes/*immunology/physiology
;
Blood Vessels/physiology
;
Cell Adhesion
;
Cell Movement
;
Chemokines/physiology
;
Endothelium, Vascular/cytology/physiology
;
Homeostasis
;
Humans
;
Lymphoid Tissue/immunology
;
Receptors, Lymphocyte Homing/*physiology
;
T-Lymphocytes/*immunology/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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