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  • 1
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    Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-11
    Description: Niemann-Pick type C (NP-C) disease, a fatal neurovisceral disorder, is characterized by lysosomal accumulation of low density lipoprotein (LDL)-derived cholesterol. By positional cloning methods, a gene (NPC1) with insertion, deletion, and missense mutations has been identified in NP-C patients. Transfection of NP-C fibroblasts with wild-type NPC1 cDNA resulted in correction of their excessive lysosomal storage of LDL cholesterol, thereby defining the critical role of NPC1 in regulation of intracellular cholesterol trafficking. The 1278-amino acid NPC1 protein has sequence similarity to the morphogen receptor PATCHED and the putative sterol-sensing regions of SREBP cleavage-activating protein (SCAP) and 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carstea, E D -- Morris, J A -- Coleman, K G -- Loftus, S K -- Zhang, D -- Cummings, C -- Gu, J -- Rosenfeld, M A -- Pavan, W J -- Krizman, D B -- Nagle, J -- Polymeropoulos, M H -- Sturley, S L -- Ioannou, Y A -- Higgins, M E -- Comly, M -- Cooney, A -- Brown, A -- Kaneski, C R -- Blanchette-Mackie, E J -- Dwyer, N K -- Neufeld, E B -- Chang, T Y -- Liscum, L -- Strauss, J F 3rd -- Ohno, K -- Zeigler, M -- Carmi, R -- Sokol, J -- Markie, D -- O'Neill, R R -- van Diggelen, O P -- Elleder, M -- Patterson, M C -- Brady, R O -- Vanier, M T -- Pentchev, P G -- Tagle, D A -- New York, N.Y. -- Science. 1997 Jul 11;277(5323):228-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9211849" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; *Carrier Proteins ; Cholesterol/*metabolism ; Cholesterol, LDL/metabolism ; Chromosome Mapping ; Chromosomes, Human, Pair 18 ; Cloning, Molecular ; *Drosophila Proteins ; Homeostasis ; Humans ; Hydroxymethylglutaryl CoA Reductases/chemistry ; Insect Proteins/chemistry ; Intracellular Signaling Peptides and Proteins ; Lysosomes/metabolism ; *Membrane Glycoproteins ; Membrane Proteins/chemistry ; Molecular Sequence Data ; Mutation ; Niemann-Pick Diseases/*genetics/metabolism ; Polymorphism, Single-Stranded Conformational ; Proteins/chemistry/*genetics/physiology ; Receptors, Cell Surface/chemistry ; Sequence Homology, Amino Acid ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    On the fundamental groups of some open rational surfaces (1996)
    Springer
    Mathematische Annalen 306 (1996), S. 15-30 
    Details
    ISSN: 1432-1807
    Keywords: 14J25 ; 14M20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01445240
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  • 3
    Electronic Resource
    Electronic Resource
    The Mtv29 gene encoding endogenous lymphoma superantigen in SJL mice, mapped to proximal chromosome 6 (1997)
    Springer
    Immunogenetics 46 (1997), S. 163-166 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050257
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  • 4
    Electronic Resource
    Electronic Resource
    A proposed intermittency measurement method for transitional boundary layer flows (1995)
    Springer
    Experiments in fluids 19 (1995), S. 426-428 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A new turbulent intermittency detector method, based on the Turbulent Energy Recognition Algorithm (TERA), has been proposed. Its performance was compared with two other available methods using the data obtained from hot-wire measurements in a developing boundary layer flow on a concave surface with constant radius of curvature of 2 m. Comparisons show that this new method is better than the other two as a turbulent detector under the same flow conditions, especially in the near-wall and in the outer and outside regions of the boundary layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190260
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  • 5
    Electronic Resource
    Electronic Resource
    Semiempirical calculations and scanning probe microscopy studies of polythiophene thin films (1995)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 13213-13216 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100035a027
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  • 6
    Electronic Resource
    Electronic Resource
    Uniform J-shifting approach for calculating reaction rate constant (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 110 (1999), S. 7622-7626 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: This paper presents a new uniform J-shifting approach for accurate calculation of rate constant in quantum dynamics study of chemical reaction. Instead of using a fixed shifting constant B in the standard J-shifting approach, the current method employs a temperature-dependent shifting constant which is obtained through an optimization procedure at a given temperature. By utilizing the calculated reaction probabilities at only a few total angular momentum values of J, the current approach automatically gives uniformly accurate rate constant across the entire range of temperature. Numerical studies of several benchmark reaction systems, including the H+H2, H2+OH and H2+CN reactions, show explicitly that the uniform J-shifting approach is far superior to the standard J-shifting approach and it provides a robust method for accurate and efficient calculation of reaction rate constant in rigorous quantum dynamics study of chemical reaction. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.478802
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  • 7
    Electronic Resource
    Electronic Resource
    Distributed approximating functional approach to the Fokker–Planck equation: Time propagation (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 3239-3246 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Fokker–Planck equation is solved by the method of distributed approximating functionals via forward time propagation. Numerical schemes involving higher-order terms in Δt are discussed for the time discretization. Three typical examples (a Wiener process, an Ornstein–Uhlenbeck process, and a bistable diffusion model) are used to test the accuracy and reliability of the present approach, which provides solutions that are accurate up to ten significant figures while using a small number of grid points and a reasonably large time increment. Two sets of solutions for the bistable system, one computed using the eigenfunction expansion of a preceding paper and the other using the present time-dependent treatment, agree to no fewer than five significant figures. It is found that the distributed approximating functional method, while simple in its implementation, yields the most accurate numerical solutions yet available for the Fokker–Planck equation. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474674
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  • 8
    Electronic Resource
    Electronic Resource
    Distributed approximating functional approach to the Fokker–Planck equation: Eigenfunction expansion (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 5216-5224 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The distributed approximating functional method is applied to the solution of the Fokker–Planck equations. The present approach is limited to the standard eigenfunction expansion method. Three typical examples, a Lorentz Fokker–Planck equation, a bistable diffusion model and a Henon–Heiles two-dimensional anharmonic resonating system, are considered in the present numerical testing. All results are in excellent agreement with those of established methods in the field. It is found that the distributed approximating functional method yields the accuracy of a spectral method but with a local method's simplicity and flexibility for the eigenvalue problems arising from the Fokker–Planck equations. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.473520
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  • 9
    Electronic Resource
    Electronic Resource
    Drop formation in viscous flows at a vertical capillary tube (1997)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 9 (1997), S. 2234-2242 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Drop formation at the tip of a vertical, circular capillary tube immersed in a second immiscible fluid is studied numerically for low-Reynolds-number flows using the boundary integral method. The evolution and breakup of the drop fluid is considered to assess the influences of the viscosity ratio λ, the Bond number B, and the capillary number C for 10−2≤λ≤10, 10−2≤C≤1, and 0.1≤B≤5. For very small λ, breakup occurs at shorter times, there is no detectable thread between the detaching drop and the remaining pendant fluid column, and thus no large satellite drops are formed. The distance to detachment increases monotonically with λ and changes substantially for λ〉1, but the volume of the primary drop varies only slightly with λ. An additional application of the numerical investigation is to consider the effect of imposing a uniform flow in the ambient fluid [e.g., Oguz and Prosperetti, J. Fluid Mech. 257, 111 (1993)], which is shown to lead to a smaller primary drop volume and a longer detachment length, as has been previously demonstrated primarily for high-Reynolds-number flows. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.869346
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  • 10
    Electronic Resource
    Electronic Resource
    Burgers' equation with high Reynolds number (1997)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 9 (1997), S. 1853-1855 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Burgers' equation, involving very high Reynolds numbers, is numerically solved by using a new approach based on the distributed approximating functional for representing spatial derivatives of the velocity field. For moderately large Reynolds numbers, this simple approach can provide very high accuracy while using a small number of grid points. In the case where the Reynolds number ≥105, the exact solution is not available and a discrepancy exists in the literature. Our results clarify the behavior of the solution under these conditions. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.869305
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