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  • Articles  (596)
  • 1995-1999  (596)
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  • 1
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    Requirement for the adapter protein GRB2 in EGF receptor endocytosis (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-28
    Description: Activated epidermal growth factor (EGF) receptors induce the formation of various complexes of intracellular signaling proteins that are mediated by SRC homology 2 (SH2) and SH3 domains. The activated receptors are also rapidly internalized into the endocytotic compartment and degraded in lysosomes. EGF stimulation of canine epithelial cells induced a rapid and transient association of the SH3-SH2-SH3 protein GRB2 with dynamin, a guanosine triphosphatase that regulates endocytosis. Disruption of GRB2 interactions by microinjection of a peptide corresponding to the GRB2 SH2 domain or its phosphopeptide ligand blocked EGF receptor endocytosis; other SH2 domains that bind EGF receptors or antibodies that neutralize RAS did not. Both activation and termination of EGF signaling appear to be regulated by the diverse interactions of GRB2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Z -- Moran, M F -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1935-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Banting and Best Department of Medical Research, University of Toronto, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658166" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptor Proteins, Signal Transducing ; Animals ; Antibodies, Monoclonal ; Cell Line ; Dogs ; Dynamins ; *Endocytosis/drug effects ; Epidermal Growth Factor/pharmacology ; GRB2 Adaptor Protein ; GTP Phosphohydrolases/metabolism ; Microinjections ; Peptide Fragments/pharmacology ; Proteins/*metabolism ; Receptor, Epidermal Growth Factor/*metabolism ; Receptors, Transferrin/metabolism ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction ; ras Proteins/immunology/physiology ; src Homology Domains/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-31
    Description: CHOP, a member of the C/EBP family of transcription factors, mediates effects of cellular stress on growth and differentiation. It accumulates under conditions of stress and undergoes inducible phosphorylation on two adjacent serine residues (78 and 81). In vitro, CHOP is phosphorylated on these residues by p38 mitogen-activated protein kinase (MAP kinase). A specific inhibitor of p38 MAP kinase, SB203580, abolished the stress-inducible in vivo phosphorylation of CHOP. Phosphorylation of CHOP on these residues enhanced its ability to function as a transcriptional activator and was also required for the full inhibitory effect of CHOP on adipose cell differentiation. CHOP thus serves as a link between a specific stress-activated protein kinase, p38, and cellular growth and differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, X Z -- Ron, D -- New York, N.Y. -- Science. 1996 May 31;272(5266):1347-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 10016, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650547" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Adipocytes/cytology ; Amino Acid Sequence ; Animals ; *CCAAT-Enhancer-Binding Proteins ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Cell Differentiation ; Cell Division ; Culture Media ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Enzyme Inhibitors/pharmacology ; Imidazoles/pharmacology ; Methyl Methanesulfonate/pharmacology ; Mice ; *Mitogen-Activated Protein Kinases ; Molecular Sequence Data ; Phosphorylation ; Pyridines/pharmacology ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Transcription Factor CHOP ; Transcription Factors/chemistry/genetics/*metabolism ; Transcriptional Activation ; p38 Mitogen-Activated Protein Kinases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Absorption and Raman spectra of Se8-ring clusters in zeolite 5A (1996)
    Elsevier
    Details
    Publication Date: 1996-12-01
    Print ISSN: 0038-1098
    Electronic ISSN: 1879-2766
    Topics: Physics
    Published by Elsevier
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  • 4
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    Ecology of newly formed sea ice in the Weddell Sea, Antarctica I. Chlorophyll a and nutrients (1997)
    In:  EPIC3Chinese J Polar Sci, 8(1), pp. 18-26
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and Crystal Structure of SnP2S6 (1995)
    s.l. : American Chemical Society
    Chemistry of materials 7 (1995), S. 856-858 
    Details
    ISSN: 1520-5002
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/cm00053a007
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  • 6
    Electronic Resource
    Electronic Resource
    Structures and Magnetic Susceptibility Studies of Four New High-Nuclearity Copper(II) Halide Oligomers (1995)
    s.l. : American Chemical Society
    Inorganic chemistry 34 (1995), S. 3134-3141 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00116a003
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  • 7
    Electronic Resource
    Electronic Resource
    Crystal Structure of (Et2Me2N)3Cu4Cl11: An Antiferromagnetic Chain of Ferromagnetically Coupled Tetramers (1995)
    s.l. : American Chemical Society
    Inorganic chemistry 34 (1995), S. 2870-2874 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00115a013
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  • 8
    Electronic Resource
    Electronic Resource
    Yangtze Delta, China: Taihu lake-level variation since the 1950s, response to sea-level rise and human impact (1999)
    Springer
    Environmental geology 37 (1999), S. 333-339 
    Details
    ISSN: 1432-0495
    Keywords: Key words Flood ; Human impact ; Lake-level and sea-level rise ; Yangtze Delta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Hydrological records collected from water gauge stations since the 1950s demonstrate that the Taihu lake level is rising. The average rate of the lake-level rise is 0.4–1.1 mm/year during the non-flood season, resulting directly from a rise in sea level. High rates of 3.0–5.0 mm/year of rise are even recorded during the wet season. This indicates increasing human activities such as reclamation, sluicing and embanking, which significantly hinder the expulsion of extra lake water to the coast shortly after a rainfall. Generally, the lake level of the western inlet is higher than that of the eastern outlet. However, the lake-level difference between the west and east has been diminished annually from ∼10–15 cm in the 1950s to 〈3 cm at the present time. During non-flood seasons, the lake-level difference even appears to be reversed, indicating a retrogression of the lake flow from east to west. It is predicted that the Taihu drainage basin will lose much of its natural water-expelling ability in the next 50 years as the sea level continues to rise, and retrogression will likely occur during the flood season in the near future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050392
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  • 9
    Electronic Resource
    Electronic Resource
    Spring abundance and distribution of the ctenophore Pleurobrachia pileus in the Seine estuary: advective transport and diel vertical migration (1995)
    Springer
    Marine biology 124 (1995), S. 313-324 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Several sets of plankton and hyperbenthos samples were collected from the Seine estuary in late May-early June of 1991, 1992 and 1994, and the abundance, size-frequency, horizontal and vertical distribution, and short-term fluctuations of Pleurobrachia pileus (O.F. Müller, 1776) were determined. In the Seine estuary, P. pileus was more abundant than reported for any other European shallow waters. Its depth-averaged density was 33 individuals m-3 in 1991 and 32 individuals m-3 in 1992, with a maximum density of 808 individuals m-3. The ctenophores displayed passive tidal advection and active diel vertical migration. In the outer estuary, high abundances were observed around low tide, and diel vertical migration was very pronounced. However, many individuals remained aggregated near the bottom at all times. In spring, the distribution of P. pileus coincided with the 33 and 150‰ S isohalines, with high abundances on the marine side of the estuary. It is suggested that aggregation of ctenophores near the bottom and diel vertical migration play an important role in the retention of P. pileus in the estuary. Two schemes of P. pileus life cycle in the Bay of Seine are proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347135
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  • 10
    Electronic Resource
    Electronic Resource
    Choline Modulates Cardiac Membrane Repolarization by Activating an M3 Muscarinic Receptor and its Coupled K+ Channel (1999)
    Springer
    The journal of membrane biology 169 (1999), S. 55-64 
    Details
    ISSN: 1432-1424
    Keywords: Key words: M3 muscarinic acetylcholine receptor — Choline — Heart rate — Action potential duration — K+ current — Receptor binding assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Choline is a necessary substrate of the lipid membrane and for acetylcholine synthesis. Accumulating evidence indicates that besides being a structural component, choline is also a functional modulator of the membrane. It has been shown to be a muscarinic acetylcholine receptor (mAChR) agonist and can induce a novel K+ current in cardiac cells. However, the potential role of choline in modulating cardiac functions remained unstudied despite that mAChRs are known to be important in regulating heart functions. With microelectrode techniques, we found that choline produced concentration-dependent (0.1∼10 mm) decreases in sinus rhythm and action potential duration in isolated guinea pig atria. The effects were reversed by 2 nm 4DAMP (an M3-selective antagonist). Whole-cell patch-clamp recordings in dispersed myocytes from guinea pig and canine atria revealed that choline is able to induce a K+ current with delayed rectifying properties. The choline-induced current was suppressed by low concentrations of 4DAMP (2∼10 nm). Antagonists toward other subtypes (M1, M2 or M4) all failed to alter the current. The affinity of choline (K d ) at mAChRs derived from displacement binding of [3H]-NMS in the homogenates from dog atria was 0.9 mm, consistent with the concentration needed for the current induction and for the HR and APD modulation. Our data indicate that choline modulates the cellular electrical properties of the hearts, likely by activating a K+ current via stimulation of M3 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005901
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