Publication Date:
1996-08-16
Description:
The plant hormone auxin regulates various developmental processes including root formation, vascular development, and gravitropism. Mutations within the AUX1 gene confer an auxin-resistant root growth phenotype and abolish root gravitropic curvature. Polypeptide sequence similarity to amino acid permeases suggests that AUX1 mediates the transport of an amino acid-like signaling molecule. Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product. The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bennett, M J -- Marchant, A -- Green, H G -- May, S T -- Ward, S P -- Millner, P A -- Walker, A R -- Schulz, B -- Feldmann, K A -- New York, N.Y. -- Science. 1996 Aug 16;273(5277):948-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688077" target="_blank"〉PubMed〈/a〉
Keywords:
2,4-Dichlorophenoxyacetic Acid/pharmacology
;
Amino Acid Sequence
;
Amino Acid Transport Systems
;
Amino Acids/metabolism
;
Arabidopsis/chemistry/*genetics/growth & development/metabolism
;
*Arabidopsis Proteins
;
Biological Transport
;
Cloning, Molecular
;
DNA, Bacterial/genetics
;
*Genes, Plant
;
Genetic Complementation Test
;
*Gravitropism
;
Indoleacetic Acids/metabolism/pharmacology
;
Membrane Transport Proteins/chemistry
;
Molecular Sequence Data
;
Molecular Weight
;
Mutation
;
Plant Proteins/chemistry/*genetics/metabolism
;
Plant Roots/*growth & development/metabolism
;
Sequence Alignment
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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