Publication Date:
1995-12-15
Description:
Evidence suggests that CD8+ T lymphocytes are involved in the control of human immunodeficiency virus (HIV) infection in vivo, either by cytolytic mechanisms or by the release of HIV-suppressive factors (HIV-SF). The chemokines RANTES, MIP-1 alpha, and MIP-1 beta were identified as the major HIV-SF produced by CD8+ T cells. Two active proteins purified from the culture supernatant of an immortalized CD8+ T cell clone revealed sequence identity with human RANTES and MIP-1 alpha. RANTES, MIP-1 alpha, and MIP-1 beta were released by both immortalized and primary CD8+ T cells. HIV-SF activity produced by these cells was completely blocked by a combination of neutralizing antibodies against RANTES, MIP-1 alpha, and MIP-1 beta. Recombinant human RANTES, MIP-1 alpha, and MIP-1 beta induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). These data may have relevance for the prevention and therapy of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cocchi, F -- DeVico, A L -- Garzino-Demo, A -- Arya, S K -- Gallo, R C -- Lusso, P -- New York, N.Y. -- Science. 1995 Dec 15;270(5243):1811-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8525373" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Amino Acid Sequence
;
Animals
;
Antiviral Agents/*physiology
;
CD8-Positive T-Lymphocytes/*immunology
;
Cell Division/physiology
;
Cell Line
;
Cells, Cultured
;
Chemokine CCL4
;
Chemokine CCL5/antagonists & inhibitors/*immunology
;
Culture Media, Conditioned
;
Cytokines/antagonists & inhibitors/*immunology
;
Dose-Response Relationship, Immunologic
;
Escherichia coli
;
HIV Infections/immunology
;
HIV-1/*immunology
;
HIV-2/immunology
;
Herpesvirus 6, Human/immunology
;
Herpesvirus 7, Human/immunology
;
Human T-lymphotropic virus 1/immunology
;
Humans
;
Immunoglobulin G/immunology
;
Lymphocyte Activation
;
Macaca nemestrina
;
Macrophage Inflammatory Proteins
;
Molecular Sequence Data
;
Monokines/antagonists & inhibitors/*immunology
;
Recombinant Proteins/immunology
;
Simian Immunodeficiency Virus/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
