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  • Springer  (2,778)
  • 1995-1999  (2,778)
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Publisher
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Overexpression ofADH1 confers hyper-resistance to formaldehyde inSaccharomyces cerevisiae (1996)
    Springer
    Current genetics 29 (1996), S. 437-440 
    Details
    ISSN: 1432-0983
    Keywords: Yeast ; Formaldehyde ; Hyper-resistance ; Alcohol dehydrogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In an attempt to clone genes involved in resistance to formaldehyde we have screened a genomic library based on the episomal plasmid YEp24 for the ability to increase resistance to formaldehyde in a wild-type strain. In addition toSFA, the gene encoding the formaldehyde dehydrogenase Adh5, an enzyme most potent in formaldehyde de-toxification, we isolated a second plasmid that conferred a less pronounced but significant hyper-resistance to formaldehyde. Its passenger DNA contained the geneADH1, encoding alcohol dehydrogenase 1 (EC 1.1.1.1), which could be shown to be responsible for the observed hyper-resistance phenotype. Construction of anadh1-0 mutant revealed that yeast lacking a functionalADH1 gene is sensitive to formaldehyde. While glutathione is essential for Adh5-mediated formaldehyde de-toxification, Adh1 reduced formaldehyde best in the absence of this thiol compound. Evidence is presented that formaldehyde is a substrate for Adh1 in vivo and in vitro and that its cellular de-toxification employs a reductive step that may yield methanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02221511
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation and Characterization of Epitaxial CaSi2 and Siloxene Layers on Silicon (1999)
    Springer
    Monatshefte für Chemie 130 (1999), S. 79-87 
    Details
    ISSN: 1434-4475
    Keywords: Keywords. Anisotropy of IR absorption; CaSi2 epitaxy; Diode structure; Structural analysis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung.  Das epitaktische Wachstum dünner CaSi2-Filme auf verschiedenen Siliziumoberflächen wird beschrieben. Die Umwandlung des Silizids in Siloxen ergibt unterschiedlich orientierte epitaktische Siloxenfilme von hoher Schichtqualität. Die strukturelle Qualität von CaSi2 und Siloxen wurde mit Hilfe von Transmissionselektronen- und Rastertunnelmikroskopie sowie Röntgendiffraktion untersucht. Siloxen auf (110)-Si ermöglicht einen direkten Nachweis der anisotropen Schwingungseigenschaften mittels IR-Transmissionsmessungen. Mit Siloxen und Kontakten mit unterschiedlicher Austrittsarbeit zur Ladungsträgerinjektion wurde eine Diodenstruktur hergestellt.
    Notes: Summary.  Epitaxial growth of thin CaSi2 films on various silicon surfaces is described. Transforming the silicide into siloxene leads to high quality epitaxial siloxene films with different orientations. The structural quality of CaSi2 and siloxene is investigated by transmission and scanning electron microscopy as well as X-ray diffraction analysis. Siloxene on (110)-Si enables direct observation of the anisotropic vibrational properties by IR transmission measurements. A diode structure was realized with siloxene by using contacts with different work functions as charge carrier injectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010177
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  • 3
    Electronic Resource
    Electronic Resource
    Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae (1996)
    Springer
    Current genetics 29 (1996), S. 437-440 
    Details
    ISSN: 1432-0983
    Keywords: Key words Yeast ; Formaldehyde ; Hyper-resistance ; Alcohol dehydrogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  In an attempt to clone genes involved in resistance to formaldehyde we have screened a genomic library based on the episomal plasmid YEp24 for the ability to increase resistance to formaldehyde in a wild-type strain. In addition to SFA, the gene encoding the formaldehyde dehydrogenase Adh5, an enzyme most potent in formaldehyde de-toxification, we isolated a second plasmid that conferred a less pronounced but significant hyper-resistance to formaldehyde. Its passenger DNA contained the gene ADH1, encoding alcohol dehydrogenase 1 (EC 1.1.1.1), which could be shown to be responsible for the observed hyper-resistance phenotype. Construction of an adh1-0 mutant revealed that yeast lacking a functional ADH1 gene is sensitive to formaldehyde. While glutathione is essential for Adh5-mediated formaldehyde de-toxification, Adh1 reduced formaldehyde best in the absence of this thiol compound. Evidence is presented that formaldehyde is a substrate for Adh1 in vivo and in vitro and that its cellular de-toxification employs a reductive step that may yield methanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050068
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  • 4
    Electronic Resource
    Electronic Resource
    Low Bone Density with Normal Bone Turnover in Ovariectomized and Streptozotocin-Induced Diabetic Rats (1998)
    Springer
    Calcified tissue international 62 (1998), S. 260-265 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Diabetes — Ovariectomy — Bone mineral density — Bone markers — Rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Diabetes and estrogen deficit are known causes of osteopenia, diabetes being associated with a low bone turnover and estrogen deficit with a high bone turnover. In the present work, we studied the effect of combined ovariectomy and diabetes on bone mineral content (BMC) and bone mineral density (BMD) and several bone markers in the rat. Four groups of rats were studied: control (C), ovariectomized (O), diabetic (D), and ovariectomized and diabetic (DO). Twelve weeks after starting the experiments, BMC and BMD of the first six lumbar vertebrae were measured; a bone formation marker (BGP) and a bone resorption marker (free collagen cross-links, PYD) were also analyzed. Diabetic rats showed diminished gain in bone mass, BMC (D: 0.417 ± 0.028 g, DO: 0.422 ± 0.020 g) and BMDs (D: 0.171 ± 0.006 g/cm2, DO: 0.174 ± 0.006 g/cm2) both being significantly (P 〈 0.001) lower than those of control (C: BMC 0.727 ± 0.024 g and BMD 0.258 ± 0.004 g/cm2) and ovariectomized (O: BMC 0.640 ± 0.044 g and BMD 0.240 ± 0.009 g/cm2) groups. Moreover, the BMC and BMD of the C group were significantly (P 〈 0.05) higher than that of the O group. BGP and PYD levels were significantly (P 〈 0.01) higher in the O group (BGP: 138.2 ± 16.8 ng/ml, PYD: 270.2 ± 17.8 nM/mM) than those found in the control rats (BGP: 44.7 ± 4.8 ng/ml, PYD: 165.6 ± 12.5 nM/mM); the D group showed significantly (P 〈 0.01) lower values (BGP: 27.4 ± 14.6 ng/ml, PYD: 55.0 ± 7.4 nM/mM) than those of the control group. The DO group showed similar levels (BGP: 43.4 ± 5.1 ng/ml, PYD: 146.7 ± 14.6 nM/mM) to those found in the C group. Although bone marker levels in the O and D groups were in accordance with those expected in these situations, in the DO group the corresponding levels are apparently ``normal.'' Also, the decrease of gain in bone mass observed after combining estrogen deficit and diabetes (DO group) did not seem to be more marked than that caused by diabetes alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900427
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  • 5
    Electronic Resource
    Electronic Resource
    Preference for gradual resolution of uncertainty (1997)
    Springer
    Theory and decision 43 (1997), S. 167-185 
    Details
    ISSN: 1573-7187
    Keywords: Temporal risk attitude ; timing of uncertainty resolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology , Economics
    Notes: Abstract Analyses of preference for the timing of uncertainty resolution usually assumes all uncertainty to resolve in one point in time. More realistically, uncertainty should be modelled to resolve gradually over time. Kreps and Porteus (1978) have introduced an axiomatically based model of time preference which can explain preferences for gradual uncertainty resolution. This paper presents an experimental test of the Kreps-Porteus model. We derive implications of the model relating preferences for gradual and one-time resolving lotteries. Our data do not support the Kreps-Porteus model but show that some of the behaviour observed may be explained by similarity heuristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004983003069
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  • 6
    Electronic Resource
    Electronic Resource
    Interspecies Pharmacokinetics of a Novel Hematoregulatory Peptide (SK&F 107647) in Rats, Dogs, and Oncologic Patients (1996)
    Springer
    Pharmaceutical research 13 (1996), S. 794-797 
    Details
    ISSN: 1573-904X
    Keywords: allometric scaling ; peptide ; pharmacokinetics ; hematology ; infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To study the pharmacokinetics of SK&F 107647, a novel hematoregulatory agent, in rats, dogs, and patients with non-lymphoid solid tumor malignancy. Methods. Sprague Dawley rats and beagle dogs (n = 6 each; 3 M, 3 F) were given 25 mg/kg of SK&F 107467 as an iv bolus injection, and patients (n = 6; 4 M, 2 F) received 100 ng/kg as a 2 hour iv infusion. Plasma samples were assayed for drug using either HPLC (rat and dog) or RIA (human). Results. In each species the plasma clearance (CL) of SK&F 107647 was low in relation to hepatic blood flow, and the volume of distribution (Vdss) was reflective of distribution to extracellular body water. The plasma CL in humans was near that of average glomerular filtration rate. Using allometric equations for interspecies scaling (Y = a·Wb), body-weight normalized human pharmacokinetic data were reasonably predicted using either the body weight normalized rat or the dog data. The allometric exponents (b) for CL, Vdss, and T1/2 of SK&F 107647 were 0.63, 0.94, and 0.29, respectively. Conclusions. Use of a limited pool of available animal data allowed for reasonable predictions of human pharmacokinetics of SK&F 107647.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016020221300
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  • 7
    Electronic Resource
    Electronic Resource
    An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants (1997)
    Springer
    Human genetics 〈Berlin〉 101 (1997), S. 121-125 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Immortalized B lymphocytes from Werner syndrome subjects are shown to be hypersensitive to 4-nitroquinoline-1-oxide (4NQO), supporting earlier work on T lymphocytes. We also show that B cell lines from clinically normal heterozygous carriers exhibit sensitivities to this genotoxic agent, which are intermediate to those of wild-type and homozygous mutants. 4NQO is shown to induce an apoptotic response. These data encourage research on DNA repair with such cell lines and raise the question of an enhanced sensitivity of the relatively prevalent heterozygous carriers to certain environmental genotoxic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050599
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  • 8
    Electronic Resource
    Electronic Resource
    Localisation of a gene for Papillon-Lefèvre syndrome to chromosome 11q14–q21 by homozygosity mapping (1997)
    Springer
    Human genetics 〈Berlin〉 101 (1997), S. 376-382 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Papillon-Lefèvre syndrome is an autosomal recessively inherited palmoplantar keratoderma of unknown aetiology associated with severe periodontitis leading to premature loss of dentition. Three consanguineous families, two of Turkish and one of German origin, and three multiplex families, one of Ethiopian and two of German origin, with 11 affected and 6 unaffected siblings in all were studied. A targeted genome search was initially attempted to several candidate gene regions but failed to demonstrate linkage. Therefore a genome-wide linkage scan using a combination of homozygosity mapping and traditional linkage analysis was undertaken. Linkage was obtained with marker D11S937 with a maximum two-point lod score of Z max = 6.1 at recombination fraction θ = 0.00 on chromosome 11q14–q21 near the metalloproteinase gene cluster. Multipoint likelihood calculations gave a maximum lod score of 7.35 between D11S901 and D11S1358. A 9.2-cM region homozygous by descent in the affected members of the three consanguineous families lies between markers D11S1989 and D11S4176 harbouring the as yet unknown Papillon-Lefèvre syndrome gene. Haplotype analyses in all the families studied support this localisation. This study has identified a further locus harbouring a gene for palmoplantar keratoderma and one possibly involved in periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050645
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  • 9
    Electronic Resource
    Electronic Resource
    PolyFormes: software for the declarative modelling of polyhedra (1999)
    Springer
    The visual computer 15 (1999), S. 55-76 
    Details
    ISSN: 1432-2315
    Keywords: Key words: Geometric modelling ; Declarative modelling ; Uniform polyhedron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003710050162
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  • 10
    Electronic Resource
    Electronic Resource
    Seasonal distribution of sympagic amphipods near Chesterfield Inlet, N.W.T., Canada (1997)
    Springer
    Polar biology 18 (1997), S. 16-22 
    Details
    ISSN: 1432-2056
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The seasonal distribution of sympagic amphipods was investigated in the Chesterfield Inlet area of northwestern Hudson Bay (63°30′N). Amphipod abundance was measured by photographic samples and species composition was determined by sweep net samples. Twelve species of amphipods were collected, the most common being Ischyrocerus anguipes, Pontogeneia inermis, Apherusa megalops and Weyprechtia pinguis. The major environmental variable affecting amphipod distribution was water depth. Amphipod abundance was highest near 20 m and near zero past 50 m. The maximum recorded abundance was 1367 m−2. A minor factor affecting the distribution of amphipods was snow depth, through its modifying effect on light and thereby the growth of ice algae. Amphipods began to inhabit the sea ice shortly after its formation. From the beginning of March, the number of amphipods on the ice increased steadily to about the 3rd week of April, after which numbers declined. This pattern coincided with the seasonal ice algae abundance. Amphipods reduced ice algal biomass over 20-m depth by 63%. No evidence of diurnal changes in abundance was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003000050154
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