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  • 1
    Electronic Resource
    Electronic Resource
    Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 750-754 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Werner syndrome (WS) is characterized by the premature onset and accelerated rates of development of major geriatric disorders, including atherosclerosis, diabetes mellitus, osteoporosis, ocular cataracts, and various neoplasms. Cultures of WS skin-fibroblastlike cells have been previously shown to undergo accelerated rates of decline of their replicative potentials and to exhibit variegated chromosomal translocations and deletions. Since the replicative decline of normal somatic cells is associated with a loss of telomeric repeats, we investigated the kinetics of telomeric repeat loss in WS cells. The mean length of telomere restriction fragments (TRF) from the earliest passages of WS cells studied was not shorter than those of controls, possibly reflecting selective pressure for subsets of cells with relatively high residual replicative capacity. Statistical evidence indicated an accelerated shortening of TRF length in serially passaged WS cultures, but the mean TRF lengths of WS cultures that had ceased replicating were significantly longer than those of senescent controls. Thus, while accelerated loss of telomeric repeats could potentially explain the rapid decline in proliferation of WS cells, it is possible that WS cells exit the cell cycle via mechanisms that differ from those of replicatively senescent cells from control subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050131
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  • 2
    Electronic Resource
    Electronic Resource
    Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 750-754 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Werner syndrome (WS) is characterized by the premature onset and accelerated rate of development of major geriatric disorders, including atherosclerosis, diabetes mellitus, osteoporosis, ocular cataracts, and various neoplasms. Cultures of WS skin-fibroblastlike cells have been previously shown to undergo accelerated rates of decline of their replicative potentials and to exhibit variegated chromosomal translocations and deletions. Since the replicative decline of normal somatic cells is associated with a loss of telomeric repeats, we investigated the kinetics of telomeric repeat loss in WS cells. The mean length of telomere restriction fragments (TRF) from the earliest passages of WS cells studied was not shorter than those of controls, possibly reflecting selective pressure for subsets of cells with relatively high residual replicative capacity. Statistical evidence indicated an accelerated shortening of TRF length in serially passaged WS cultures, but the mean TRF lengths of WS cultures that had ceased replicating were significantly longer than those of senescent controls. Thus, while accelerated loss of telomeric repeats could potentially explain the rapid decline in proliferation of WS cells, it is possible that WS cells exit the cell cycle via mechanisms that differ from those of replicatively senescent cells from control subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346184
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution and heat-treatment migration studies of Cr implanted GaAs by SIMS (1980)
    Springer
    Applied physics 23 (1980), S. 21-24 
    Details
    ISSN: 1432-0630
    Keywords: 65 ; 68 ; 79.20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Depth profiles of 190 keV Cr implanted-GaAs have been measured by SIMS analysis. The as-implanted Cr profiles are approximately Gaussian with good agreement between theory and experiment on the projected range. A fast migration of Cr is observed after heat treatment under encapsulation, and even as soon as the silicon nitride film is deposited. There is no evidence for Cr precipitation, even in the case of the largest implanted dose (1015 cm−2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00899565
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  • 4
    Electronic Resource
    Electronic Resource
    Vanadium Catalysis of the Oxidation of Catechol Amines, Dihydroxyphenylalanine and 5-Hydroxyindoles (1960)
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 884-885 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Glassware which had been washed in sulphuric acid - dichromate solution was treated with warm nitric acid, 0-01M versene and 12-15 rinses of de-ionized water having a specific resistance 〉 106 ohms at 25 C. All reagents were made up with de-ionized water. To 0-01 M concentrations of substrates ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/186884a0
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for Multiple Cæruloplasmin Components in Human Serum (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 927-929 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sera were obtained from 43 pregnant women (in the third trimester of pregnancy or within a few days post partum), 17 patients with various diseases (Table 1) and 5 normal individuals. A voltage gradient of 5 V./cm. was maintained for periods of 16-20 hr. at room temperature. Half of each starch-gel ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/190927b0
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  • 6
    Electronic Resource
    Electronic Resource
    Mitotic Nondisjunction in Cultivated Human Cells (1967)
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 612-613 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The propositus was an infant in whom mongolism was diagnosed at birth. At 3 days of age, foreskin explants were cultured and maintained in Waymouth?s medium with 10 per cent newborn calf serum, as previously described4. The established fibroblast cultures (Strain A) were stored at ? 75 C in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/214612a0
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of dislocations on threshold voltage of GaAs field-effect transistors (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 62 (1987), S. 1097-1101 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Measurements of threshold voltage of GaAs FET's (field-effect transistors) show a larger heterogeneity when dislocated rather than free dislocated substrates are used. Therefore, the aim of this study is to find an accurate model for the influence of dislocations on such devices. The model proposed takes into account a cumulative effect of each dislocation located on or around the FET on the value of VT. This effect is merely a function of the distance between the dislocation and the FET. With the use of a computer, the best influence curve has been determined for one wafer. Nevertheless, due to differences in thermal histories, this curve can vary from wafer to wafer. Therefore, it is suggested that, in addition to the average standard deviation of the threshold voltage, it could be accurate to give the influence curve to characterize the substrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.339715
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  • 8
    Electronic Resource
    Electronic Resource
    Evidence of the origin of infrared scattering in GaAs with high-resolution infrared tomography (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 62 (1987), S. 3700-3703 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Transmission electron microscopy and A-B etching are the usual methods to observe microprecipitates in GaAs substrates. More recently, tomography has been used to characterize GaAs wafers and infrared light scattering was assumed to be caused by microprecipitates. Work on high-resolution tomography which confirms this assumption is presented in this paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.339251
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  • 9
    Electronic Resource
    Electronic Resource
    Dominant susceptibility genes (1990)
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 124-124 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALZHEIMER'S disease is widely recognized as the most common form of dementia in older people, at least in most Western societies. Its prevalence (as determined by a set of clinical diagnostic guidelines, including important exclusionary criteria) increases exponentially as a function of age: a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/347124a0
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  • 10
    Electronic Resource
    Electronic Resource
    Clonal variants of constitutive heterochromatin of human fibroblasts after recovery from mitomycin treatment (1973)
    Springer
    Chromosoma 43 (1973), S. 203-210 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Presumptive clones of human skin fibroblast-like cells surviving mitomycin C treatments show a variety of intra- and interchromosomal rearrangements limited to the constitutive heterochromatic regions. Starting with a wild-type line polymorphic for chromosome no. 1 heterochromatin, we have observed clones with complete symmetry and varying degrees of asymmetry of the no. 1 heterochromatin, translocations of “excess” chromosome 1 heterochromatin to one no. 9 member, interstitial translocations to sites normally devoid of heterochromatin, and duplication of the Y chromosome long arm heterochromatin. In the case of the chromosome no. 1 pair, the extent of heterochromatin variation was quantitated to test the hypothesis that discrete classes of variants occur. There appear to be two types of variants: Those showing reciprocal changes between homologues (2 examples) and those showing a change in the amount of heterochromatin of a single homologue (5 examples). The latter group showed an approximately linear series of variants. Unequal cross-over following repair after damage from the alkylating agent is considered the most likely explanation for the observed changes, given the repetitive nature of DNA at these heterochromatic sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00483379
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