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  • Life and Medical Sciences  (322)
  • Lunar and Planetary Science and Exploration  (154)
  • ASTROPHYSICS
  • 1995-1999  (539)
  • 1920-1924  (4)
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  • 1
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    A Mercury Frequency Standard Engineering Prototype for the NASA Deep Space Network (1996)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: An engineering prototype linear ion trap frequency standar (LITS-4) using (sup 199)Hg+ is operational and currently under test for NASA's Deep Space Network (DSN). The DSN requires high stability and reliability with continuous operation.
    Keywords: Lunar and Planetary Science and Exploration
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  • 2
    Electronic Resource
    Electronic Resource
    Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box (1996)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 61 (1996), S. 310-324 
    Details
    ISSN: 0730-2312
    Keywords: osteocalcin ; transcriptional regulation ; homeodomain protein ; Msx ; bone-specific ; OC box ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Bone-specific expression of the osteocalcin gene is transcriptionally controlled. Deletion analysis of osteocalcin promoter sequences by transient transfection of osseous (ROS 17/2.8) and nonosseous (R2 fibroblast) cells revealed that the most proximal 108 nucleotides are sufficient to confer tissue-specific expression. By gel mobility shift assays with wild-type and mutated oligonucleotides and nuclear extracts from several different cell lines we identified a novel transcription factor complex which exhibits sequence-specific interactions with the primary transcriptional element, the OC box (nt -99 to -76). This OC box binding protein (OCBP) is present only in osteoblast-like cells. Methylation interference demonstrated association of the factor with OC box sequences overlapping the Msx homeodomain consensus binding site. By assaying several mutations of the OC box, both in gel shift and transient transfection studies using ROS 17/2.8, we show the following. First, binding of OCBP correlates with osteocalcin promoter activity in ROS 17/2.8 cells. Increased binding leads to a 2-3-fold increase in transcription, while decreased binding results in transcription 30-40% of control. Second, homeodomain protein binding suppresses transcription. However, Msx expression is critical for full development of the bone phenotype as determined by antisense studies. Last, we show that one of the mutations of the OC box permits expression of osteocalcin in non-osseous cell lines. In summary, we demonstrate association of at least two classes of tissue-restricted transcription factors with the OC box element, the OCBP and Msx proteins, supporting the concept that these sequences contribute to defining tissue specificity. © 1996 Wiley-Liss, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    Analysis of epitope structure of PSP94 (prostate secretory protein of 94 amino acids): (II) epitope mapping by monoclonal antibodies (1997)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 65 (1997), S. 186-197 
    Details
    ISSN: 0730-2312
    Keywords: epitope mapping ; monoclonal antibodies ; linear epitope ; immuno-dominant ; immuno-recessive ; ELISA ; competitive ELISA ; recombinant GST-PSP94 ; N-terminal and C-terminal peptides ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: PSP94 has shown potential to be a serum biomarker for evaluating prostate cancer. Studies of the epitope structure is crucial for this endeavour. In this article, we have used 15 different monoclonal antibodies (MAb) to analyse the epitope structure of PSP94 and to compare with the results obtained from our previous work using polyclonal antibody and recombinant PSP94. Firstly, we determined the relative activities of the 15 MAb population by direct and competitive ELISA. The two predominant MAbs (MAb PSP-6 and -19) in 15 MAbs were selected for further studies of the epitope structure. By comparing the binding activities of recombinant GST-PSP94 and natural PSP94 with MAbs, and by comparing their affinity with MAbs in an in vitro denaturing experiment, PSP94 was shown to have a similar, prevalently linear epitope structure as we demonstrated by polyclonal antibody. Using recombinant GST fusion protein with PSP94 and with each half of the N- and C-terminal 47 amino acids (GST-PSP-N47/C47) in E. coli cells, the different epitopes recognized by 15 monoclonal antibodies were delineated and the polar distribution of the epitope structure of PSP94 was characterized. Results of direct ELISA of recombinant N47 and C47 and their competitive binding against natural PSP94 (competitive ELISA) showed that the N- and C-termini represent the immuno-dominant and immuno-recessive area separately. A majority of the monoclonal antibodies (12/15) showed preferential binding of the N-terminal sequence of the PSP94 protein. Using GST-PSP-N47 as a standard protein, an epitope map of the 15 monoclonal antibodies was obtained. The results of this study will help to define the clinical utility of PSP94. J. Cell. Biochem. 65:186-197. © 1997 Wiley-Liss, Inc.
    Additional Material: 8 Ill.
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  • 4
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    A geochemical model for the formation of hydrothermal carbonates on Mars (1995)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: It is often argued that substantially more carbon dioxide and water were degassed from the martian interior than can be found at present in the atmosphere, polar caps and regolith. Calculations have shown that atmospheric escape cannot account for all of the missing volatiles. Suggestions that carbon dioxide is stored as marine or lacustrine deposits, are challenged by Earth-based and spacecraft remote-sensing data. Moreover, recent modelling of the martian atmosphere suggests that rainfall or open bodies of water are in any case unlikely to have persisted for extended periods of time. Hydrothermal carbonates therefore provide a possible solution to this dilemma. Using an accessible terrestrial system (Iceland) as a guide to the underlying processes, and a host rock composition inferred from the least-altered martian meteorite, we present a geochemical model for the formation of carbonates in possible martian hydrothermal systems. Our results suggest that an extensive reservoir of carbonate minerals--equivalent to an atmospheric pressure of carbon dioxide of at least one bar--could have been sequestered beneath the surface by widespread hydrothermal activity in the martian past.
    Keywords: Lunar and Planetary Science and Exploration
    Type: Nature (ISSN 0028-0836); Volume 377; 6548; 406-8
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  • 5
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    The Gravity Field of the Moon from the Lunar Prospector Mission (1998)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: The Lunar Prospector (LP) spacecraft has provided the first polar low latitude measurement of the lunar gravity field and as a result gives significant improvement in the lunar gravity field model.
    Keywords: Lunar and Planetary Science and Exploration
    Type: Science
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  • 6
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    BATSE observations of gamma-ray burst spectra. 2: Peak energy evolution in bright, long bursts (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We investigate spectral evolution in 37 bright, long gamma-ray bursts observed with the Burst and Transient Source Experiment (BATSE) spectroscopy detectors. High-resolution spectra are chracterized by the energy of the peak of nu F(sub nu), and the evolution of this quantity is examined relative to the emission intensity. In most cases it is found that this peak energy either rises with or slightly precedes major intensity increases and softens for the remainder of the pulse. Interpulse emission is generally harder early in the burst. For bursts with multiple intensity pulses, later spikes tend to be softer than earlier ones, indicating that the energy of the peak of nu F(sub nu) is bounded by an envelope which decays with time. Evidence is found that bursts in which the bulk of the flux comes well after the event which triggers the instrument tend to show less peak energy variability and are not as hard as several bursts in which the emission occurs promptly after the trigger. Several recently proposed burst models are examined in light of these results and no qualitative conflicts with the observations presented here are found.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 1; p. 307-321
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  • 7
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    The unusual helium variable AM Canum Venaticorum (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: The unusual variable star AM CVn has puzzled astronomers for over 40 years. This object, both a photometric and spectroscopic variable, is believed to contain a pair of hydrogen-deficient white dwarfs of extreme mass ratio, transferring material via an accretion disk. We examine the photometric properties of AM CVn, analyzing 289 hours of high-speed photometric data spanning 1976 to 1992. The power spectrum displays significant peaks at 988.7, 1248.8, 1902.5, 2853.8, 3805.2, 4756.5, and 5707.8 microHz (1011.4, 800.8, 525.6, 350.4, 262.8, 210.2, and 175.2 s). We find no detectable power at 951.3 microHz (1051 s), the previously reported main frequency. The 1902.5, 2853.9, and 3805.2 microHz peaks are multiplets, with frequency splitting in each case of 20.77 +/- 0.05 microHz. The 1902.5 microHz seasonal pulse shapes are identical, within measurement noise, and maintain the same amplitude and phase as a function of color. We have determined the dominant frequency to be 1902.50902 +/- 0.00001 microHz with dot P = +1.71 (+/- 0.04) x 10(exp -11) s/s. We discuss the implications of these findings on a model for AM CVn.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 2; p. 927-938
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  • 8
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    Chromospheric variations in main-sequence stars (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: The fluxes in passbands 0.1 nm wide and centered on the Ca II H and K emission cores have been monitored in 111 stars of spectral type F2-M2 on or near the main sequence in a continuation of an observing program started by O. C. Wilson. Most of the measurements began in 1966, with observations scheduled monthly until 1980, when observations were schedueld sevral times per week. The records, with a long-term precision of about 1.5%, display fluctuations that can be idntified with variations on timescales similar to the 11 yr cycle of solar activity as well as axial rotation, and the growth and decay of emitting regions. We present the records of chromospheric emission and general conclusions about variations in surface magnetic activity on timescales greater than 1 yr but less than a few decades. The results for stars of spectral type G0-K5 V indicate a pattern of change in rotation and chromospheric activity on an evolutionary timescale, in which (1) young stars exhibit high average levels of activity, rapid rotation rates, no Maunder minimum phase and rarely display a smooth, cyclic variation; (2) stars of intermediate age (approximately 1-2 Gyr for 1 solar mass) have moderate levels of activity and rotation rates, and occasional smooth cycles; and (3) stars as old as the Sun and older have slower rotation rates, lower activity levels and smooth cycles with occasional Maunder minimum-phases.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 438; 1; p. 269-287
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  • 9
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    Asymmetry in the Diurnal Variation of Surface Albedo (1996)
    In:  CASI
    Details
    Publication Date: 2019-07-10
    Description: Remote sensing of surface properties and estimation of clear-sky and surface albedo generally assumes that the albedo depends only on the solar zenith angle. The effects of dew, frost, and precipitation as well as evaporation and wind can lead to some systematic diurnal variability resulting in an asymmetric diurnal cycle of albedo. This paper examines the symmetry of both surface-observed albedos and top-of-the-atmosphere (TOA) albedos derived from satellite data. Broadband and visible surface albedos were measured at the Department of Energy Atmospheric Radiation Measurement (ARM) Program Southern Great Plains Central Facility, at some fields near the ARM site, and over a coniferous forest in eastern Virginia. Surface and wind conditions are available for most cases. GOES-8 satellite radiance data are converted to broadband albedo using bidirectional reflectance functions and an empirical narrowband-to-broadband relationship. The initial results indicate that surface moisture has a significant effect and can change the albedo in the afternoon by 20% relative to its morning counterpart. Such effects may need to be incorporated in mesoscale and even large-scale models of atmospheric processes.
    Keywords: Lunar and Planetary Science and Exploration
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  • 10
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    Preliminary Correlations of Gravity and Topography from Mars Global Surveyor (1999)
    In:  Other Sources
    Details
    Publication Date: 2019-07-17
    Description: The Mars Global Surveyor (MGS) spacecraft is currently in a 400-km altitude polar mapping orbit and scheduled to begin global mapping of Mars in March of 1999. Doppler tracking data collected in this Gravity Calibration Orbit prior to the nominal mapping mission combined with observations from the MGS Science Phasing Orbit in Spring - Summer 1999 and the Viking and mariner 9 orbiters has led to preliminary high resolution gravity fields. Spherical harmonic expansions have been performed to degree and order 70 and are characterized by the first high spatial resolution coverage of high latitudes. Topographic mapping by the Mars Orbiter Laser Altimeter on MGS is providing measurements of the height of the martian surface with sub-meter vertical resolution and 5-30 m absolute accuracy. Data obtained during the circular mapping phase are expected to provide the first high resolution measurements of surface heights in the southern hemisphere. The combination of gravity and topography measurements provides information on the structure of the planetary interior, i.e. the rigidity and distribution of internal density. The observations can also be used to address the mechanisms of support of surface topography. Preliminary results of correlations of gravity and topography at long planetary wavelengths will be presented and the implications for internal structure will be addressed.
    Keywords: Lunar and Planetary Science and Exploration
    Type: Jun 01, 1999 - Jun 03, 1999; Boston, MA; United States
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