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  • 1
    Electronic Resource
    Electronic Resource
    Taxonomic relationships between four species of the Mullidae family revealed by three genetic methods: allozymes, random amplified polymorpic DNA and mitochondrial DNA (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 55 (1999), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Genetic distances were lower between Upeneus moluccensis and Pseudopeneus prayensis than between those species and Mullus barbatus and Mullus surmuletus. However, for allozymes, the two Mullus species were found genetically more distinct from U. moluccensis than from P. prayensis, but RAPD and mtDNA analysis showed the opposite. RAPDs revealed less interspecific divergence compared with allozymes and the results they produced were more consistent with mtDNA analysis. Although RAPDs did not add any supplementary taxonomic information, they proved valuable tools for quick and reliable species discrimination compared with allozymes and mtDNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1999.tb00700.x
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  • 2
    Electronic Resource
    Electronic Resource
    P-glycoprotein is expressed in parathyroid epithelium and is regulated by calcium (1995)
    Springer
    Calcified tissue international 56 (1995), S. 170-174 
    Details
    ISSN: 1432-0827
    Keywords: Multidrug resistance ; P-glycoprotein ; Parathyroid ; Calcium regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract P-glycoprotein (Pgp), the multidrug resistance (mdr) gene product, has been described in normal tissues with diverse physiologic functions. A broad role as a transporter protein for toxins, hormones, and physiologic metabolites has been provisionally deduced, based on structural analysis and immunoanatomic localization. Recently, significant levels of Pgp have been demonstrated in endocrine and hormonally responsive tissues and tumors. We examined calcium-regulated, clonal parathyroid epithelial (PT-r) and endothelial cells (BPE-1) and frozen parathyroid tissue from normal human parathyroid, parathyroid hyperplasia, parathyroid adenoma, and parathyroid carcinoma for expression of the multidrug resistance gene (Mdr1) and Pgp utilizing Northern and Western analysis and immunohistochemistry. We also investigated the effect of extracellular calcium (eCa) on Pgp expression in PT-r cells at the molecular/cellular level. Immunohistochemistry, utilizing three murine monoclonal antibodies (MAbs)—C494, JSB-1, and C219—which recognize spatially distinct cytoplasmic epitopes of Pgp, revealed strong immunoreactivity in PT-r cells, normal parathyroid, and parathyroid hyperplasia, and weak immunostaining in parathyroid adenomas. BPE-1 cells, endothelial cells, and parathyroid carcinoma were negative. PT-r cells showed a single 130 kDa band (120 KDa after glycosidase treatment) on Western blot and a 4.6 kb transcript on Northern analysis, consistent with Pgp. Western and Northern blot analysis of PTr cells cultured in different eCa concentrations showed that eCa up-regulated Pgp expression. Northern analysis of doxorubicin-resistant human breast carcinoma cells (Adr1) (MCF-7) exhibited constitutive expression of Pgp mRNA without modifications, with increasing eCa concentrations. We conclude that N-glycosylated Pgp is expressed in parathyroid epithelial cells and that calcium responsiveness of Pgp expression appears cell specific.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296351
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  • 3
    Electronic Resource
    Electronic Resource
    Release of histamine from rat mast cells by acetylcholine (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 473-474 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mast cells from the abdominal and thoracic cavities of male Wistar albino rats (weight 200-400 g) were collected according to the method of Thon and Uvnas5 and, after gradient centrifugation in Ficoll (Pharmacia), suspended in a medium containing NaCl 145 mM, CaCl2 0.9 mM, KC1 2.4 mM, glucose 0.1 % ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/273473a0
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  • 4
    Electronic Resource
    Electronic Resource
    Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase (1998)
    [s.l.] : Nature America Inc.
    Nature genetics 19 (1998), S. 199-202 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Telomeric DNA of mammalian chromosomes consists of several kilobase-pairs of tandemly repeated sequences with a terminal 3´ overhang in single-stranded form. Maintaining the integrity of these repeats is essential for cell survival; telomere attrition is associated with chromosome ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/575
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  • 5
    Electronic Resource
    Electronic Resource
    Age-related alterations in cell division and cell cycle kinetics in control and trimethyltin-treated lymphocytes of human individuals (1995)
    Springer
    BioMetals 8 (1995), S. 263-269 
    Details
    ISSN: 1572-8773
    Keywords: aging ; cell cycle kinetics ; cell division ; lymphocytes ; trimethyltin chloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Trimethyltin chloride induced age-related suppression of cell division and cell cycle kinetics in human peripheral blood lymphocytes cultured in RPMI 1640 culture medium supplemented with human AB serum, phytohemagglutinin and bromodeoxyuridine. A high frequency of M1 (first metaphase) cells was seen in cultures treated with a high dose (C 1 = 1.0 μg per culture) and in lymphocytes from donors in the age range 40–70 years. The delay in cell division and cell cycle kinetics may indicate a longer duration in DNA synthesis induced by trimethyltin chloride in aged lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00143386
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  • 6
    Electronic Resource
    Electronic Resource
    Temperature distribution for MHD flow between coaxial cylinders with discontinuity in wall temperatures (1979)
    Springer
    Flow, turbulence and combustion 35 (1979), S. 67-83 
    Details
    ISSN: 1573-1987
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The temperature distribution in the MHD axial flow between two coaxial infinite cylinders under a transverse radial magnetic field has been found out when there is a discontinuity in the wall temperatures at a section of the channel. The numerical values of temperature distribution at large distances from the section have been worked out first for various Hartman numbers. To this is superimposed the perturbation introduced due to discontinuity. Near the region of discontinuity the approximate matching is done by using the finite difference method. Tables and graphs are given to depict the behaviour with various Hartman numbers. A relief of the temperature distribution is also given. It is found that the temperature shows a decreasing tendency with increasing Hartman number, a well-known characteristic of such type of problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00382655
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  • 7
    Electronic Resource
    Electronic Resource
    Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 9 (1997), S. 297-302 
    Details
    ISSN: 0899-0042
    Keywords: anti-inflammatory drugs ; ibuprofen ; clinical pharmacokinetics ; bioinversion ; enantiomers ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (designated trade name: Spedifen®), 400 mg (-)R-ibuprofen arginine or 400 mg (+)S-ibuprofen arginine.Plasma levels of both enantiomers were monitored up to 480 minutes after drug intake using an enantioselective analytical method (HPLC with ultraviolet detection) with a quantitation limit of 0.25 mg/l.Substantial inter-subject variability in the evaluated pharmacokinetic parameters was observed in the present study. After (+)S-ibuprofen arginine, the following mean pharmacokinetic parameters ±SD were calculated for (+)S-ibuprofen: tmax 28.6 ± 28.4 min; Cmax 36.2 ± 7.7 mg/l; AUC 86.4 ± 14.9 mg · h/l; t½ 105.2 ± 20.4 min. After (-)R-ibuprofen arginine, the following mean pharmacokinetic parameters were calculated for (+)S-ibuprofen and (-)R-ibuprofen, respectively: tmax 90.0 ± 17.3 and 50.5 ± 20.5 min; Cmax 9.7 ± 3.0 and 35.3 ± 5.0 mg/l; AUC 47.0 ± 17.2 and 104.7 ± 27.7 mg · h/l; t½ 148.1 ± 63.6 and 97.7 ± 23.3 min. After racemic ibuprofen arginine, the following mean pharmacokinetic parameters were calculated for (+)S- and (-)R-ibuprofen, respectively: tmax 30.7 ± 29.1 and 22.9 ± 29.8 min.; Cmax 29.9 ± 5.6 and 25.6 ± 4.4 mg/l; AUC 105.1 ± 23.0 and 65.3 ± 15.0 mg · h/l; t½ 136.6 ± 20.7 and 128.6 ± 45.0 min. Tmax values of S(+)- and (-)R-ibuprofen after a single dose of 400 mg of each enantiomer did not differ significantly from the corresponding parameters obtained after a single dose of 800 mg of racemic ibuprofen arginine, indicating that the absorption rate of (-)R- and (+)S-ibuprofen is not different when the two enantiomers are administered alone or as a racemic compound. An average of 49.3 ± 9.0% of a dose of the (-)R-ibuprofen arginine was bioinverted into its antipode during the study period (480 minutes post-dosing). The percent bioinversion during the first 30 minutes after (-)R-ibuprofen arginine intake averaged 8.1 ± 3.9%. The mean AUC of (+)S-ibuprofen calculated after 800 mg racemic ibuprofen arginine (105.1 ± 23.0 mg · h/l) was lower than the mean AUC value obtained by summing the AUCs of (+)S-ibuprofen after administration of 400 mg (+)S-ibuprofen arginine and 400 mg (-)R-ibuprofen arginine (133.4 ± 26.6 mg · h/l).In conclusion, the administration of Spedifen® resulted in very rapid absorption of the (+)S-isomer (eutomer) with tmax values much lower than those observed for this isomer when conventional oral solid formulations such as capsules or tablets of racemic ibuprofen are administered. This characteristic is particularly favourable in those conditions in which a very rapid analgesic effect is required. Chirality 9:297-302, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Some numerical experiments on high accuracy fast direct finite difference method for elliptic problems (1996)
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 12 (1996), S. 631-641 
    Details
    ISSN: 1069-8299
    Keywords: numerical analysis ; fast direct method ; elliptic problems ; finite difference methods ; eigenvalue problems ; harmonic ; biharmonic ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A high accuracy finite difference scheme has been developed for solving some elliptic problems which appear in engineering and applied sciences. These include Laplace, Poisson, Helmholtz and related equations. The second- and fourth-order problems dealing with vibration of membranes and plates have also been examined. Numerically, the problem reduces to a block tridiagonal system which can be solved by suitably modifying the fast direct method developed by Hockney. Comparison has been made with results obtained from some alternative numerical methods or analytical methods whenever available
    Additional Material: 3 Ill.
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  • 9
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    Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy (1998)
    National Academy of Sciences
    Details
    Publication Date: 1998-09-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Thermistor controlled gunn oscillator at Ka-band (1997)
    Springer
    Details
    Publication Date: 1997-04-01
    Print ISSN: 1866-6892
    Electronic ISSN: 1866-6906
    Topics: Physics
    Published by Springer
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