Abstract
PARASYMPATHETIC stimulation using either acetylcholine or carbamylcholine at nanomolar to picomolar concentrations enhances antigen-induced release of histamine from various IgE sensitised tissues (human lungs1, human nasal polyps2). The enhancement induced by cholinomimetic compounds is blocked by pretreatment with atropine, so is probably affected through a muscarinic receptor3. However, enhancement of histamine release by cholinergic treatment has not been observed from peripheral human leukocytes sensitised with human IgE (ref. 3). This discrepancy, as well as the lack of information on the effect of acetylcholine on histamine-storing cells, have prompted us to investigate the action of acetylcholine on non-evoked histamine release from isolated purified rat mast cells. To our knowledge, only Kiernan4 has studied the effects of acetylcholine on isolated mast cells, and failed to substantiate any significant morphological change. We present here the results of a study of the effects of acetylcholine on the morphology and on histamine release of rat mast cells, and show that low concentrations of acetylcholine are sufficient to cause histamine release.
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FANTOZZI, R., MASINI, E., BLANDINA, P. et al. Release of histamine from rat mast cells by acetylcholine. Nature 273, 473–474 (1978). https://doi.org/10.1038/273473a0
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DOI: https://doi.org/10.1038/273473a0
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