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  • 1995-1999  (47)
  • 1990-1994  (50)
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  • 1
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    Regulation of transcription by a protein methyltransferase (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-26
    Description: The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase 1 (CARM1), a previously unidentified protein that binds to the carboxyl-terminal region of p160 coactivators, enhanced transcriptional activation by nuclear receptors, but only when GRIP1 or SRC-1a was coexpressed. Thus, CARM1 functions as a secondary coactivator through its association with p160 coactivators. CARM1 can methylate histone H3 in vitro, and a mutation in the putative S-adenosylmethionine binding domain of CARM1 substantially reduced both methyltransferase and coactivator activities. Thus, coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, D -- Ma, H -- Hong, H -- Koh, S S -- Huang, S M -- Schurter, B T -- Aswad, D W -- Stallcup, M R -- AG00093/AG/NIA NIH HHS/ -- DK43093/DK/NIDDK NIH HHS/ -- NS17269/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jun 25;284(5423):2174-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology HMR 301, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10381882" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Histone Acetyltransferases ; Histones/metabolism ; Methylation ; Mice ; Molecular Sequence Data ; Mutation ; Nuclear Receptor Coactivator 1 ; Nuclear Receptor Coactivator 2 ; Nuclear Receptor Coactivator 3 ; Protein-Arginine N-Methyltransferases/chemistry/genetics/*metabolism ; Receptors, Androgen/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Thyroid Hormone/metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Trans-Activators/*metabolism ; Transcription Factors/metabolism ; *Transcriptional Activation ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Ab initio calculation of band structure, x-ray emission, quantum yield, and electron-energy-loss spectra of hexagonal boron nitride (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 7422-7426 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The band structure of hexagonal boron nitride (BN) has been calculated using an ab initio linear combination of pseudoatomic-orbitals method. The calculated band structure confirms a previous finding that this material is an indirect band-gap insulator and has two empty interlayer bands. Projected densities of states are compared with the experimental x-ray emission spectra of B and N K edges and the agreement is good. This good agreement between the present ground-state calculation and the experimental x-ray emission spectra supports our previous finding that there should be very little valence electron relaxation effect on x-ray emission spectra. A real-space Green's function technique and the Z+1 approximation have been used to calculate the exciton spectra of B and N K edges. The first peak at 192 eV in B K edge is found to be a bound exciton with a binding energy of 1.7±0.4 eV. Only resonance is found for the N K edge. The calculated exciton spectra agree very well with the experimental quantum-yield and electron-energy-loss spectra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.353983
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  • 3
    Electronic Resource
    Electronic Resource
    Theoretical study of laser heating and dissociation reactions in solids using ultrafast time-resolved x-ray diffraction (1992)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 72 (1992), S. 2174-2178 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A theory of ultrafast time-resolved x-ray diffraction is presented. We show that for the case in which vibrational relaxation is fast, the x-ray diffraction intensities in pulse laser heating are determined by the Debye–Waller factor. We also show how the scattering intensities of the diffraction spots change with the position of the dissociating atoms in a time-resolved x-ray diffraction experiment studying dissociation reactions in solids. Our results show that the scattering intensities change in both the fully dissociated and the partially dissociated cases, and that time-resolved x-ray diffraction could be a useful tool in probing dissociation reactions in solids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.351607
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of exchange bond disorder on transport measurements : 38th Annual Conference on Magnetism and Magnetic Materials (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 6510-6512 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Measurements of the low field resistive anisotropy (LFRA) in amorphous Fe91Zr9 with and without hydrogen loading are presented. The temperature dependence of these data is compared with model calculations of the quadrupolar term [〈〈S2Z〉T〉J−S(S+1)/3], from which it is concluded that the model calculations reproduce both the temperature and the exchange bond dependence of this transport coefficient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356931
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  • 5
    Electronic Resource
    Electronic Resource
    The spontaneous resistive anisotropy in amorphous and hydrogenated FeZr (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 5964-5966 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Measurements of the spontaneous resistive anisotropy(SRA)—basically the difference between the longitudinal and transverse magnetoresistance extrapolated to zero induction—in amorphous FeZr as a function of field (0–1 T) and temperature (1.5–300 K) are presented. The Fe concentrations investigated range from 89 to 92 at. % and the effects of hydrogenation have also been studied. For the hydrogen-free samples a nonzero SRA develops at the ferromagnetic ordering (Curie) temperature Tc and persists to the lowest attainable temperature, with no obvious anomaly in the vicinity of the proposed transverse-spin freezing temperature Txy. With the inclusion of hydrogen, both Tc and the magnitude of the SRA increase, and attempts are made to correlate such increases with the changes in band structure and mean iron moment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.346029
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  • 6
    Electronic Resource
    Electronic Resource
    Theoretical comparison of electron energy-loss and x-ray absorption near-edge fine structure of the Si L2,3 edge (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 68 (1990), S. 288-290 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Various approximations in the calculations of electron energy-loss cross section and x-ray absorption coefficient have been evaluated using the Si L2,3 edge as an example. It was found that the random phase approximation, for which the cross terms are neglected in the expressions of electron energy-loss cross section and x-ray absorption coefficient, is a very good approximation. The dipole approximation in the calculation of the electron energy-loss cross section was found to begin to break down even at small acceptance half angles, such as 12.5 mrad. For energy losses larger than that of the Si L2,3 edge the dipole approximation will break down faster. This approximation also fails for a large scattering angle even at a small energy loss. The electron energy-loss cross section and x-ray absorption coefficient of the Si L2,3 edge has been calculated and compared. The large difference in relative intensity reported experimentally between the two spectra is not confirmed in this study. More experimental comparisons between electron energy loss and x-ray absorption spectra are recommended for Si and other compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347129
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  • 7
    Electronic Resource
    Electronic Resource
    A modified parametrization scheme for the complete neglect of differential overlap method with relativistic correction of orbital exponents and energy levels with particular applications to rare earth compounds (1992)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 96 (1992), S. 4518-4525 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A new unified parametrization scheme for the complete neglect of differential overlap method, applicable to heavy atom systems is formulated. The exponents ζμ and electronegativities X(μ) of atomic orbitals are corrected by the relativistic Dirac–Fock expectation values of atomic orbital radii and energy levels. This leads to the possibility of calibrating the β0 parameters directly by the equilibrium geometric configuration of molecules. The parametrization for hydrogen, halides, and rare earth series, as well as some test calculations for compounds of these elements, have been carried out to show the utility of the scheme. The results demonstrate that the present scheme can give satisfactory MO levels and ionization potentials as well as correct molecular geometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.462813
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  • 8
    Electronic Resource
    Electronic Resource
    Sources of phase noise in homodyne and heterodyne phase modulation devices used for tissue oximetry studies (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 3042-3054 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The objective of this study was to characterize sources of phase noise in homodyne and heterodyne phase modulation devices (PMDs) used for tissue oximetry measurements. Each PMD incorporates a laser diode modulated at a radio frequency in the 50–200 MHz range, an optical detector and a homodyne/heterodyne phase sensitive detector. The intensity modulated light which propagates through tissue is attenuated and undergoes a phase shift, which reflects the mean time of flight of the photons through the tissue. The measured amplitude and phase can be used to determine hemoglobin saturation in tissues using equations based on diffusion theory. Four studies were performed to characterize the sources of phase noise. First, the signal to noise ratio was characterized to determine if the PMDs are operating at the shot noise or detector noise limit. Second, the accuracy of the three PMDs for measuring phase shifts in tissue were compared by using them to measure the phase shift as a function of path length change in air, at a constant amplitude, and at signal to noise ratios comparable to that measured from tissue. The third source of noise measured was the phase shift that results from optical attenuation of the signal (phase-amplitude cross talk) at a constant path length, to characterize intensity dependent phase shifts in the PMDs. Finally, the interchannel interference of a dual wavelength PMD which uses radio frequency multiplexing to perform phase measurements at two wavelengths simultaneously was compared to that of a dual wavelength PMD which uses time multiplexing to perform phase measurements at two wavelengths serially to determine the effect of each on phase error. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149053
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  • 9
    Electronic Resource
    Electronic Resource
    Two-color Z-scan technique with enhanced sensitivity (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 1581-1583 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A procedure to improve the sensitivity of the two-color Z-scan technique is presented. The sensitivity of the technique as a function of the pump and the probe beam confocal parameters and their relative transverse dimensions is evaluated. The results show that, in the case of small nonlinear phase shift, the sensitivity of the measurements at the probe beam center may be a factor of 4 greater by the appropriate choice of the beams parameters. Results for arbitrary phase shift values and for detection at or out of the probe beam center are also reported. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.113858
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  • 10
    Electronic Resource
    Electronic Resource
    Light-controlled beam deflector in semiconductor doped glasses (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 63 (1993), S. 3553-3555 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report on the operation of an all-optical beam deflector whereby the deflected signal beam can be more powerful than the driving beam. Therefore, we have transferred the modulation of the driving beam to the signal beam with power gain and angular deflection rate of 10 mrad/kW. The main component of our deflector is a sample of Cd(S,Se) doped glass and its operation is based on the cross-bending effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.110094
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