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  • 2020-2024  (193)
  • 1995-1999  (2,511)
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  • 1
    Monograph available for loan
    Monograph available for loan
    Essex : Longman
    Call number: PIK N 071-96-0305
    Type of Medium: Monograph available for loan
    Pages: 369 p.
    Edition: 1. ed.
    ISBN: 0582227097
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotic communities. ; Ecology . ; Conservation biology. ; Environmental management. ; Physical geography. ; Sustainability. ; Ecosystems. ; Ecology. ; Conservation Biology. ; Environmental Management. ; Earth System Sciences. ; Sustainability.
    Description / Table of Contents: Ecosystem Collapse and Climate Change: An Introduction -- PART I. Polar and Boreal Ecosystems -- Ecosystem Collapse on a Sub-Antarctic Island -- Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions -- Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions -- A Paleo-perspective on Ecosystem Collapse in Boreal North America -- PART II. Temperate and Semi-arid Ecosystems -- The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium -- Climate-Induced Global Forest Shifts due to Heatwave-Drought -- Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia -- PART III. Tropical and Temperate Coastal Ecosystems -- Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria -- Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef -- Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems -- Marine Heatwave Drives Collapse of Kelp Forests in Western Australia -- Impact of Marine Heatwaves on Seagrass Ecosystems.
    Abstract: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: Online Resource
    Pages: VIII, 366 p. 93 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030713300
    Series Statement: Ecological Studies, Analysis and Synthesis, 241
    DDC: 577
    Language: English
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  • 4
    Monograph available for loan
    Monograph available for loan
    Seibersdorf : Austrian Research Centre
    Call number: PIK N 076-02-0028
    Type of Medium: Monograph available for loan
    Pages: 616 p.
    ISBN: 395002557
    Series Statement: EC Environment and Climate Programme DGXII/D-1 Technologies for Environmental Protection Report 8
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 5
    Monograph available for loan
    Monograph available for loan
    Cambridge : Cambridge University Press
    Call number: PIK N 322-98-0290
    Type of Medium: Monograph available for loan
    Pages: 566 p.
    Edition: 1. ed.
    ISBN: 0521563445
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 6
    Call number: 9/S 90.0096(65)
    In: Memoir
    Type of Medium: Monograph available for loan
    Pages: XIII, 454 S. + 1 Kt-Beil.
    ISBN: 0891813446
    Series Statement: AAPG memoir 65
    Classification:
    Tectonics
    Language: English
    Location: Reading room
    Branch Library: GFZ Library
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  • 7
    Monograph available for loan
    Monograph available for loan
    Alexandria, Virginia : American Geological Institute
    Call number: AWI G1-99-0138
    Type of Medium: Monograph available for loan
    Pages: XII, 769 S.
    Edition: fourth ed.
    ISBN: 0922152349
    Branch Library: AWI Library
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  • 8
    Monograph available for loan
    Monograph available for loan
    Cheltenham ; Northampton : Edward Elgar
    Call number: PIK B 020-98-0414
    Type of Medium: Monograph available for loan
    Pages: 226 p.
    ISBN: 1858988810
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 9
    Series available for loan
    Series available for loan
    London : H.M.Stat.Off.
    Associated volumes
    Call number: M 96.0246
    In: United Kingdom offshore regional report / British Geological Survey
    Type of Medium: Series available for loan
    Pages: x, 123 S.
    ISBN: 0118845071
    Series Statement: United Kingdom offshore regional report / British Geological Survey report areas 6
    Classification:
    Regional Geology
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 10
    Call number: 9/M 07.0421(494)
    In: Special publications / the Geological Society, London, No. 494
    Description / Table of Contents: A cross-border approach to exploration, appraisal and development is important in mature basins such as the North Sea, where the ‘low hanging fruit’ have long gone. This approach emphasizes the need to see the basin as one geological entity, in order to maximize economic recovery and prepare the area for the energy transition. This volume offers an up-to-date, ‘geology-without-borders’ view of the stratigraphy, sedimentology, tectonics and oil-and-gas exploration trends of the entire North Sea basin, along with the challenges associated with differences in data continuity and nomenclature across median lines. This volume includes overviews of cross-border play statistics, lithostratigraphic naming conventions and exploration performance through to new facies models for cross-border areas. As such, this volume will be a valuable reference for every geoscientist working in the North Sea for years to come.
    Type of Medium: Monograph available for loan
    Pages: vi, 504 Seiten , Illustrationen, Diagramme, Karten
    ISBN: 978-1-78620-457-8 , 9781786204578
    ISSN: 0305-8719
    Series Statement: Special publications / the Geological Society, London No. 494
    Language: English
    Note: Contents Acknowledgements Archer, S. G., Kombrink, H., Patruno, S., Chiarella, D., Jackson, C. A.-L. and Howell, J. A. / Cross-border petroleum geology in the North Sea: an introduction General North Sea Patruno, S., Kombrink, H. and Archer, S. G. / Cross-border stratigraphy of the Northern, Central and Southern North Sea: a comparative tectono-stratigraphic megasequence synthesis Kombrink, H. and Patruno, S. / The integration of public domain lithostratigraphic data into a series of cross-border North Sea well-penetration maps Quirk, D. G. and Archer, S. G. / Exploration play statistics in the Southern North Sea region of The Netherlands and UK Quirk, D. G. and Archer, S. G. / Exploration play statistics in the central–northern North Sea region of UK–Norway–Denmark Roberts, P., Jordan, O., Steen, Ø., Leppard, C., Janssen, J. S., Baudia, E., Ramm, A. and Helgesen, G. / One North Sea fairway analysis: revealing opportunities through data integration across scales Myers, K., Rouillard, P. and Zanella, E. / Exploration performance in the UK and Norwegian North Sea Quirk, D. G., Underhill, J. R., Gluyas, J. G., Howe, M. J., Wilson, H. A. M. and Anderson, S. A / low-carbon future for The North Sea Basin Paleozoic Boscolo Gallo, A., Kilhams, B., de Keijzer, M. and Nicolai, C. / Can thin coals be resolved in seismic data? An example of the challenges for Carboniferous (Visean to Westphalian) source-rock definition across the Elbow Spit Platform (Netherlands) and the Mid North Sea High (UK) through well synthetic modelling Doornenbal, J. C., Kombrink, H., Bouroullec, R., Dalman, R. A. F., De Bruin, G., Geel, C. R., Houben, A. J. P., Jaarsma, B., Juez-Larré, J., Kortekaas, M., Mijnlieff, H. F., Nelskamp, S., Pharaoh, T. C., Ten Veen, J. H., Ter Borgh, M., Van Ojik, K., Verreussel, R. M. C. H., Verweij, J. M. and Vis, G.-J. / New insights on subsurface energy resources in the Southern North Sea Basin area Daniels, S. E., Tucker, M. E., Mawson, M. J., Holdsworth, R. E., Long, J. J., Gluyas, J. G. and Jones, R. R. / Nature and origin of collapse breccias in the Zechstein of NE England: local observations with cross-border petroleum exploration and production significance, across the North Sea Scisciani, V., Patruno, S., D’Intino, N. and Esestime, P. / Paleozoic basin reactivation and inversion of the underexplored Northern North Sea platforms: a cross-border approach Mesozoic Archer, S. G., McKie, T., Andrews, S. D., Wilkins, A. D., Hutchison, M., Young-Ziolkowski, N., Osunde, C., Matheson, J., Thackrey, S., Lang, M., Sola, B., Mouritzen, C., Perrell, C., Greenwood, M., Mauritzen, E. and Tenepalli, S. / Triassic mudstones of the Central North Sea: cross-border characterization, correlation and their palaeoclimatic significance Gray, E., Hartley, A. and Howell, J. / The influence of stratigraphy and facies distribution on reservoir quality and production performance in the Triassic Skagerrak Formation of the UK and Norwegian Central North Sea Orre, L. T. E. and Folkestad, A. / Depositional environments of the Early to Middle Triassic northern North Sea in a syn-rift to a post-rift setting Galluccio, L., Foote, N., Bertouche, M., Kostic, B. and James, A. / Preliminary assessment of dolomite stringers in the Upper Jurassic Farsund Formation as a potential unconventional hydrocarbon reservoir Cenozoic Pernin, N., Feuilleaubois, L., Bird, T. and Reiser, C. / Identifying and de-risking near-field opportunities through reliable pre-stack broadband attributes: examples from the Paleocene North Sea (UK–Norway) injectites play Karstens, J., Müller, P., Berndt, C. and Patruno, S. / Deep-seated focused fluid migration as indicator for hydrocarbon leads in the East Shetland Platform, North Sea Province Medvedev, S., Hartz, E. H., Schmid, D. W., Zakariassen, E. and Varhaug, P. / Influence of glaciations on North Sea petroleum systems Index
    Location: Reading room
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