Publication Date:
2002-06-01
Description:
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantley, Lewis C -- R01 GM041890/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 May 31;296(5573):1655-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115-5713, USA. cantley@helix.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040186" target="_blank"〉PubMed〈/a〉
Keywords:
3-Phosphoinositide-Dependent Protein Kinases
;
Animals
;
Cell Membrane/metabolism
;
Cell Physiological Phenomena
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Diabetes Mellitus, Type 2/drug therapy/metabolism
;
Humans
;
Models, Biological
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Neoplasms/drug therapy/metabolism
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Phosphatidylinositol 3-Kinases/*metabolism
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Phosphatidylinositol 4,5-Diphosphate/metabolism
;
Phosphatidylinositol Phosphates/chemistry/*metabolism
;
Phosphorylation
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Protein Kinases/metabolism
;
Protein-Serine-Threonine Kinases/metabolism
;
Proto-Oncogene Proteins/metabolism
;
Proto-Oncogene Proteins c-akt
;
*Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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