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  • 1
    Electronic Resource
    Electronic Resource
    Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 197-202 
    Details
    ISSN: 1432-1041
    Keywords: hexobarbital ; cholestasis ; phenobarbital ; rifampicin ; phenytonin ; pharmackoinetics ; drug metabolism ; induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of intravenously infused hexobarbital was studied in 10 patients with intrahepatic cholestasis and in 9 with extrahepatic biliary obstruction. The results were compared with those obtained in 16 healthy young volunteers and 5 older patients with normal liver function. After infusion, the plasma concentrations showed a rapid initial decline (α-phase) and subsequently a slower decrease (β-phase). The half-life of a latter phase was 323±84 min in the healthy group, 357±151 min in the patients with intrahepatic cholestasis and 344±115 min in the group with biliary obstruction; the clearances were 3.41±0.90, 4.08±1.95 and 3.81±1.97 ml×min−1×kg−1, respectively. The differences were not statistically significant. The mean volume of the central compartment of distribution and the steady state volume of distribution were not significantly different. In two patients hexobarbital clearance during cholestasis was greater than after it had subsided. After treatment of 11 patients with cholestasis with drug metabolism-inducing agents (phenobarbital, rifampicin or phenytoin), the half-life of hexobarbital was significantly shortened and the mean value of hexobarbital clearance was more than doubled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561900
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  • 2
    Electronic Resource
    Electronic Resource
    A New Procedure for the Differentiation of 01 Vibrio cholerae and Non-01 V. cholerae Recovered From Oysters (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 48 (1983), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Live oysters were inoculated with 01 V. cholerae or non-01 V. cholerae and the liquor from the oysters was spread onto thiosulfate citrate bile salts agar plates. After incubation the colonies with yellow centers were picked and streaked onto sheep blood agar plates. Biochemical tests were performed on all colonies. Isolates exhibiting characteristic V. cholerae reactions were checked for serological identity and inoculated into a vibrio medium. After incubation, the isolates were further analyzed for lactic and succinic acids by gas-liquid chromatography. Peak height ratios of lactic/succinic acid provided a testing parameter to distinguish all isolates of 01 V. cholerae from non-01 V. cholerae isolates recovered from the oysters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1983.tb14955.x
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  • 3
    Electronic Resource
    Electronic Resource
    Minority-carrier kinetics in heavily doped GaAs:C studied by transient photoluminescence (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 5072-5078 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Room-temperature photoluminescence decay time measurements in heavily doped GaAs:C-layers designed as base layers for heterojunction bipolar transistors are reported. These measurements provide access to nonequilibrium minority carrier lifetimes that determine the current gains of those devices. By systematically studying transient luminescence spectra over a wide range of excitation densities between 1013 and 1018 cm−3, we demonstrate the importance of carrier trapping processes at low excitation densities. Optimized excitation conditions that achieve trap saturation but also avoid stimulated emission are found for densities of (1–3)×1017 cm−3/pulse. Detection is limited to a spectral window well above the energy gap (beyond 1.5 eV). Values for both Auger and radiative recombination coefficients are given. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1456244
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  • 4
    Electronic Resource
    Electronic Resource
    Gas-sensor properties of SnO2 films implanted with gold and iron ions (1997)
    Springer
    Journal of materials science 8 (1997), S. 301-306 
    Details
    ISSN: 1573-482X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract SnO2 gas-sensor films were modified by implantation of gold and iron ions. The change in electrical resistivity of the films caused by inflammable gases, H2, CO, CH4 and C2H5OH, was measured in the temperature range 100–500°C, and compared to non-implanted films. The morphological changes caused by gold and iron ion implantation were also investigated by atomic force microscopy. After ion implantation and annealing at 600°C, the sensitivity to H2 and CO gas was found to increase, and the dynamic range of the sensitivity to ethanol was improved. The sensitivity to CH4 was low before and after ion implantation. Fe2O3 (3%SnO2) film was also modified by gold ion implantation for comparison.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018535322380
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  • 5
    Electronic Resource
    Electronic Resource
    Growth of anchorage-dependent mammalian cells on microstructures and microperforated silicon membranes (1996)
    Springer
    Journal of materials science 7 (1996), S. 85-97 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Anchorage-dependent cells (mouse fibroblasts L929 and 3T3) were cultivated on microstructures made by semiconductor technology. Both cell lines showed normal growth on silicon surfaces covered with microelectrode arrays as well as on microperforated silicon membranes with square pores made by anisotropic etching (5, 10 or 20 μm edge length at the top and 1.2, 6.2 or 16.2 μm at the bottom). The cells spread over the 5 and 10 μm pores, but mostly failed to cover the 20 μm ones. They were able to cross the silicon membrane through the pores and to grow and spread on the under side of the membrane. Small pores (about 1 μm2) impeded but did not prevent cells crossing the membrane. Medium and large pores were freely crossed. Negative dielectrophoresis was used to achieve accurate positioning of cells above pores or to repel them from the chip surface (a.c., square wave, 2.5 V peak-to-peak, 5 MHz). The results are discussed with respect to their microtool applications for single-cell technologies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00058719
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  • 6
    Electronic Resource
    Electronic Resource
    Separation of the reaction products of cyanazine and terbuthylazine nitrosation by thin-layer chromatography (1998)
    Springer
    Fresenius' journal of analytical chemistry 360 (1998), S. 679-682 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract N-Nitroso-triazine herbicide species were synthesized as reference standards and their reaction products were separated by TLC. The method was established for analytical as well as for preparative amounts to achieve a sufficient separation between the educts, the byproducts and the N-nitrosated moieties. Separation of the reaction mixture was performed by two-dimensional TLC, using different mobile phases for each dimension. In the second dimension two developments were executed using the same solvent mixture. To examine the quality of performance, the separation zones were scrapped off, extracted and analyzed in the HPLC-diode array detection (DAD) mode in comparison with standards of the educts and the products of their N-nitrosation. This method minimizes the contact with the resulting N-nitroso compounds. At present nothing is known about the toxicological relevance or risk assessment on human health of N-nitrosocyanazine or N-nitrosoterbuthylazine species. Therefore the practical handling of these putative mutagenic and carcinogenic substances should be seen under the aspect of precaution and prevention of contamination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050780
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  • 7
    Electronic Resource
    Electronic Resource
    Gold electrodes from recordable CDs for mercury quantification by flow injection analysis (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 444-448 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The development of a new methodology for the construction of very efficient flow cells for mercury detection by potentiometric stripping analysis, employing the thin gold layer of recordable CDs as working ¶electrode is reported. This new source of electrodes (CDtrodes) show very attractive performance, similar to that obtained with commercial gold electrodes, with superior versatility. The low cost of this new source of “gold electrodes” allows a frequent replacement of the electrode, avoiding cumbersome clean-up treatments. Various experimental parameters have been optimized to yield low detection limits (0.25 ng/mL of mercury for 5 min deposition at 0.3 V) and good precision (standard deviation of 1.9% was obtained for 15 repetitive measurements using 10 ng/mL of mercury). Standard curves were found to be linear over the range of 0.5–100 μg L–1 of mercury. The flow cells developed were used for the quantification of mercury in oceanic and tap water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050090
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  • 8
    Electronic Resource
    Electronic Resource
    Subchronic treatment with sodium 2,3-dimercaptopropane-1-sulfonate in methylmercury poisoning (1982)
    Springer
    Bulletin of environmental contamination and toxicology 29 (1982), S. 416-421 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605605
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  • 9
    Electronic Resource
    Electronic Resource
    Hydroxyapatite nucleation on Na ion implanted Ti surfaces (2000)
    Springer
    Journal of materials science 19 (2000), S. 1029-1031 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006782818468
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  • 10
    Electronic Resource
    Electronic Resource
    Surface sensitivity of ion implanted titanium to hydroxyapatite formation (2000)
    Springer
    Journal of materials science 19 (2000), S. 443-445 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006759309358
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