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  • 1
    Electronic Resource
    Electronic Resource
    Bioactive Gelatin-Siloxane Hybrids as Tissue Engineering Scaffold (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 111 (Apr. 2006), p. 13-18 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: Ca2+-containing porous gelatin-siloxane hybrids were prepared using sol-gel process, post-gelation soaking, and freeze-drying. The porosity and pore size of the hybrids could be well controlled by the freezing temperature and the pH value of the soaking solution. The pore characteristics were related to the structure change during the soaking treatment. A bone-like apatite layer was able to form in the Ca2+-containing porous gelatin-siloxane hybrids upon soaking in a stimulated body fluid. The porous gelatin-siloxane hybrids could release gentamicin sulfate which isan antibiotic drug in bone chemotherapy. Thus, those hybrid materials are proposed to find application as novel bioactive and biodegradable scaffolds in bone tissue engineering
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/22/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.111.13.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of a Single Period of Mechanical Strain on Gene Expression Patterns of Ets1 and Cbfa1 in Murine Calvarial Sutural Osteoblast-Like Cells (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1105-1108 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Cranial sutures produce new bone at the sutural edges of the bone fronts in response toexternal stimuli. Little is known regarding the mechanism of osteogenesis in cranial sutures. Ets1and Cbfa1 are two important osteogenic transcription factors regulating the differentiation andmaturation of osteoblasts. But their function in cranial sutures is not still elucidated. We haveinvestigated the gene expression of Ets1 and Cbfa1 in rat’s calvarial sutural osteoblast-like cellsunder a single period of mechanical strain. The cells were isolated from the cranial suture of SD ratsand cultured in vitro, and subjected to a single 40 minutes mechanical strain using a four-pointbending apparatus. The gene expression patterns of Ets1 and Cbfa1 were examined by RT-PCR.Both mRNA levels of Ets1 and Cbfa1 have increased significantly within 6 and 12 hoursrespectively after mechanical strain were applied, and the increase returned to control levelthereafter. However, Ets1 and Cbfa1 exhibited different temporal expression patterns: Ets1expressed immediately after the mechanical loading and reached the maximum transcription at0.5h; whereas Cbfa1 experienced a latency period first, then increased slowly within 2 hours, andreached the maximum transcription at 6 h. The maximum transcription of Cbfa1 was about 2.58fold of that of Ets1. Ets1and Cbfa1 may play different roles in regulating bone matrix proteinexpressions in osteoblast-like cells during suture distraction and their function is time-dependent.High frequency distraction (〉2times/24h) is favourable to the maximal expression of the two genes
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1105.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Microstructure and Grain Abrasion Properties of TiC-xNi Coatings Prepared by Electro-Thermal Explosion Ultra-High Speed Spraying (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 33-37 (Mar. 2008), p. 489-494 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this work, a new method, electro-thermal explosion ultra-high speed spraying (EEUSS),was utilized to synthesize the titanium carbide based and nickel bonded (TiC-xNi) coatings. Thenickel content was varied at the weight percents of 5, 10, 15 and 20%. The microstructure andproperties of the coatings were studied by means of scanning electron microscope (SEM), X-raydiffraction (XRD) and microhardness tester, respectively. The TiC-xNi coatings had the metallurgicalbonding with the substrate, and consisted of submicron grains. The grain abrasion tests resultsshowed that the abrasion resistance of the coatings was affected by the contents of Ni
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.33-37.489.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Near-IR Sensitive Au-Au〈sub〉2〈/sub〉S Nanoparticles with Biocompatibility for Drug Delivery (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 1315-1318 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The near-infrared (NIR) sensitive Au-Au2S nanoparticles (NPs) have shown many advantages aspotential drug delivery systems. To further investigate biological safety of Au-Au2S NPs,cytotoxicity was estimated by calcein AM/EthD-1 fluorescence staining and the lactatedehydrogenase (LDH) release. The effects of NPs on apoptosis of CHL cells were determined byflow cytometry with Annexin V-FITC/PI double staining. It is evident that the Au-Au2S NPs arenon-cytotoxic below IC50 dosage
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1315.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    The Surface Valence Band Structure and Hemocompatibility of Rutile Titanium Oxide Films (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 605-608 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Rutile titanium oxide films were fabricated by reactive unbalanced magnetron sputtering.The blood compatibility is evaluated in vitro by clotting time and platelet adhesion measurement.The surface valence band electronic structure is gained by the XPS valence band spectra. The rutiletitanium oxide films exhibit attractive hemocompatibility. The result of the valence band electronicstructure of the films on the surface indicated that the rutile titanium oxide film represent an n-typesemiconductor characteristics and the characters result in the prevention of the charge transferingbetween the blood and materials and overall excellent antithrombogenic properties
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.605.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Biocompatibility of Near-IR Sensitive Au-Based Nanoparticles as the Potential Drug Delivery Carriers (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 1177-1180 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We successfully synthesized near infrared (NIR) sensitive Au(shell)-Au2S(core)nanoparticles, where Au2S dielectric core was encapsulated by a thin gold shell. The cytotoxicity invitro and biodistribution in vivo of Au-Au2S nanoparticles was studied by using NIH3T3 cells andKM mice, respectively. The quantitative analysis of Au in each tissue of mice was done by using theInductively Coupled Plasma Mass Spectrometry (ICP-MS). Au-Au2S nanoparticles (〈 300 μg/ml)showed good biocompatibility. Au-Au2S nanoparticles were preferentially taken up by the liver andspleen, and ultimately eliminated mostly in the feces
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.334-335.1177.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    The Bone Remodeling and Cellular Responses to Cranial Suture Distraction Osteogenesis in Growing Goats (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 5-8 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The purpose of the present study was to observe the response and changes of cranialsuture to the distraction forces in growing goats and to examine the expression patterns of TGF-βand BMP during suture distraction.Twenty growing goats were divided into three groups: control(n=4), experimental (n=12), and sham (n=4). A pure titanium distractor was placed in the coronalsuture in both the sham and experimental groups. After healing, the distractor was activated fordistraction of the coronal suture at a rate of 0.5 mm/day for 8 days in the experimental group. Threeanimals were killed respectively, at 0，2，4 and 8 weeks after completion of suture distraction. Noforce was applied in the sham group. X- Ray examination was taken and the coronal suture sampleswere harvested and processed for histological analysis and scanning electron microscopic analysisand immunohistochemistry of TGF-β and BMP. The coronal sutures of experimental group wereseparated successfully. Signs of intramembranous bone formation and remodeling were found in thedistracted suture，and the sutural structure almost return to its normal state at 8 weeks after end ofdistraction. At 0 and 2 weeks after completion of suture distraction, the collagen fiber bundles werestrengthened and aligned in the direction of the distracted forces. Strong expression of BMP andTGF-β were detected in the fibroblast-like cells and the active osteoblasts. At 4 weeks after suturedistraction, signs of intramembranous ossification were found in the edge areas of the distractedsuture, and the positive staining of BMP and TGF-β was still noted in the osteoblasts around thenewly formed bone trabeculae. This study suggests that cranial suture expansion can be achieved ingrowing animal by distraction osteogenesis. Mechanical strain resulted from distractor can inducethe adaptive remodeling in the cranial suture of growing goats. It also suggests BMP and TGF-βmay play very important roles in the process of bone formation and remodeling during suturedistraction osteogenesis
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.5.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Improved Fabrication of PMMA/Ag Core-Shell Nanostructures with Two Steps (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 32 (Feb. 2008), p. 33-38 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: An improved technique to fabricate PMMA/Ag core-shell nanocomposite via a two-stepprocedure is reported. The procedure includes an improved particle surface treatment and animproved, subsequent Ag reduction reaction strategy. Well-dispersed PMMA/Ag core-shellnanoparticles with uniform particle size distribution were successfully fabricated using thisimproved technique. Different functional group treatment on the PMMA particle surface led to anelectronically graded transition from the covalent bond of PMMA core to the metallic bond of silvershell. The improved fabrication technique thus allows a highly tailorable size of PMMA core andcontrollable thickness of Ag shell, which is crucial to producing a tunable plasmon resonance signalto different bio-/chem-environments
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.32.33.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 1319-1322 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Novel hybrid biomaterial of gelatin-siloxane nanoparticles (GS NPs), with positivesurface potential and lower cytotoxicity, was synthesized through a 2-step sol-gel process. ThepDNA-GS NPs complex was formulated with high encapsulation efficiency, and exhibited andefficient transfection in vitro. We thus envision that the GS NPs material could serve as non-viralgene vectors for gene therapy
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1319.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Investigation of Platelet Adhesion Behavior on Si-N-O Films Synthesized by Unbalanced Magnetron Sputtering (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 1407-1410 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Si-N-O films have drawn researcher’s much attention recently due to their potentialsuperiority in blood compatibility of biomaterials. In this paper, Si-N-O films were synthesized on〈100〉 silicon substrates by pulsed reactive unbalanced magnetron sputtering a single crystal silicontarget with high purity in a mixture atmosphere of Ar and N2. XPS and FTIR results showed theSi-N-O films synthesized at higher N2 flux could be described to random bonding model (RBM). InRBM, the Si2p existed in the form of a-Si3N4 and SiNνO4-ν (ν=0,1,2,3,4) components. Plateletadhesion behavior on Si-N-O films was assessed by platelet adhesion test and Lactate dehydrogenase(LDH) assay, qualitatively and quantitatively separately. The correlativity of film chemical structureand blood compatibility was investigated. The results of platelet adhesion and activation showed thatthe RBM film with higher N/O ratio exhibited favorable blood compatibility. It was shown that theSi-N-O film with specific composition and chemical bonding state was superior in bloodcompatibility compared to low temperature isotropic carbon (LTIC)
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1407.pdf
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