ISSN:
0959-8103
Keywords:
hydrolysis
;
drug release
;
IPN
;
gel
;
swelling
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
,
Physics
Notes:
This paper describes a novel hydrogel based on crosslinked chitosan with glutaraldehyde interpenetrating polyether polymer network. The gel can hydrolyse in acid at 37°C due to the cleavage of imine bonds within the network. At pH≥7, there is no hydrolysis. The pH-dependent release of cimetidine from the gel was also investigated.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pi.1994.210340213
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