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  • 2005-2009  (1,524)
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  • 1
    Monograph available for loan
    Monograph available for loan
    Chantilly, Va. : Mineralogical Society of America
    Associated volumes
    Call number: 11/M 07.0429
    In: Reviews in mineralogy & geochemistry
    Description / Table of Contents: The idea for this book was conceived in early June, 2005 at a paleoaltimetry workshop held at Lehigh University, Lehigh, Pennsyalvania and organized by Dork Sahagian. The workshop was funded by the tectonics program at NSF, and was designed to bring together researchers in paleoaltimetry to discuss different techniques and focus the community on ways of improving paleoelevation estimates and consequent interpretations of geodynamics and tectonics. At this meeting, some commented that a comprehensive volume describing the different methods could help advance the field. I offered to contact the Mineralogical Society of America and the Geochemical Society about publishing a RiMG volume on paleoaltimetry. Because many of the techniques used to infer paleoelevations are geochemically-based or deal with thermodynamic principles, the GS and MSA agreed to the project. Two years and roughly 1000 e-mails later, our book has arrived. The book is organized into 4 sections: Geodynamic and geomorphologic rationale (Clark). This chapter provides the broad rationale behind paleoaltimetry, i.e., why we study it. Stable isotope proxies. These 4 chapters cover theory of stable isotopes in precipitation and their response to altitudinal gradients (Rowley), and stable isotopes sytematics in paleosols (Quade, Garzione and Eiler), silicates (Mulch and Chamberlain) and fossils (Kohn and Dettman). Proxies of atmospheric properties. These 4 chapters cover temperature lapse rates (Meyer), entropy (Forest), and atmospheric pressure proxies, including total atmospheric pressure from gas bubbles in basalt (Sahagian and Proussevitch), and the partial pressure of CO2 (Kouwenberg, Kürshner, and McElwain). Note that clumped isotope thermometry (Quade, Garzione and Eiler) also provides direct estimates of temperature. Radiogenic and cosmogenic nuclides. These 2 chapters cover low-temperature thermochronologic approaches (Reiners) and cosmogenic isotopes (Riihimaki and Libarkin). Some chapters overlap in general content (e.g., basic principles of stable isotopes in precipitation are covered to different degrees in all stable isotope chapters), but no attempt was made to limit authors' discussion of principles, or somehow attempt to arrive at a "consensus view" on any specific topic. Because science advances by critical discussion of concepts, such restrictions were viewed as counterproductive. This does mean that different chapters may present different views on reliability of paleoelevation estimates, and readers are advised to read other chapters in the book on related topics – they may be more closely linked than they might at first appear! I hope readers of this book will discover and appreciate the synergy among paleoaltimetry, climate change, and tectonic geomorphology. These interrelationships create a complex, yet rich field of scientific enquiry that in turn offers insights into climate and geodynamics.
    Type of Medium: Monograph available for loan
    Pages: X, 278 S. , graph. Darst.
    ISBN: 0-939950-78-2 , 978-0-939950-78-2
    ISSN: 1529-6466
    Series Statement: Reviews in mineralogy & geochemistry 66
    Classification:
    Geochemistry
    Note: Chapter 1. The Significance of Paleotopography by Marin K. Clark, p. 1 - 22 Chapter 2. Stable Isotope-Based Paleoaltimetry: Theory and Validation by David B. Rowley, p. 23 - 52 Chapter 3. Paleoelevation Reconstruction Using Pedogenic Carbonates by Jay Quade, Carmala Garzione, and John Eiler, p. 53 - 88 Chapter 4. Stable Isotope Paleoaltimetry in Orogenic Belts – The Silicate Record in Surface and Crustal Geological Archives by Andreas Mulch and C. Page Chamberlain, p. 89 - 118 Chapter 5. Paleoaltimetry from Stable Isotope Compositions of Fossils by Matthew J. Kohn and David L. Dettman, p. 119 - 154 Chapter 6. A Review of Paleotemperature–Lapse Rate Methods for Estimating Paleoelevation from Fossil Floras by Herbert W. Meyer, p. 155 - 172 Chapter 7. Paleoaltimetry: A Review of Thermodynamic Methods by Chris E. Forest, p. 173 - 194 Chapter 8. Paleoelevation Measurement on the Basis of Vesicular Basalts by Dork Sahagian and Alex Proussevitch, p. 195 - 214 Chapter 9. Stomatal Frequency Change Over Altitudinal Gradients: Prospects for Paleoaltimetry by Lenny L. R. Kouwenberg, Wolfram M. Kürschner, and Jennifer C. McElwain, p. 215 - 242 Chapter 10. Thermochronologic Approaches to Paleotopography by Peter W. Reiners, p. 243 - 268 Chapter 11. Terrestrial Cosmogenic Nuclides as Paleoaltimetric Proxies by Catherine A. Riihimaki and Julie C. Libarkin, p. 269 - 278
    Location: Reading room
    Branch Library: GFZ Library
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  • 2
    Description / Table of Contents: The idea for this book was conceived in early June, 2005 at a paleoaltimetry workshop held at Lehigh University, Lehigh, Pennsyalvania and organized by Dork Sahagian. The workshop was funded by the tectonics program at NSF, and was designed to bring together researchers in paleoaltimetry to discuss different techniques and focus the community on ways of improving paleoelevation estimates and consequent interpretations of geodynamics and tectonics. At this meeting, some commented that a comprehensive volume describing the different methods could help advance the field. I offered to contact the Mineralogical Society of America and the Geochemical Society about publishing a RiMG volume on paleoaltimetry. Because many of the techniques used to infer paleoelevations are geochemically-based or deal with thermodynamic principles, the GS and MSA agreed to the project. Two years and roughly 1000 e-mails later, our book has arrived. The book is organized into 4 sections: (1) Geodynamic and geomorphologic rationale (Clark). This chapter provides the broad rationale behind paleoaltimetry, i.e., why we study it. (2) Stable isotope proxies. These 4 chapters cover theory of stable isotopes in precipitation and their response to altitudinal gradients (Rowley), and stable isotopes sytematics in paleosols (Quade, Garzione and Eiler), silicates (Mulch and Chamberlain) and fossils (Kohn and Dettman). (3) Proxies of atmospheric properties. These 4 chapters cover temperature lapse rates (Meyer), entropy (Forest), and atmospheric pressure proxies, including total atmospheric pressure from gas bubbles in basalt (Sahagian and Proussevitch), and the partial pressure of CO2 (Kouwenberg, Kürshner, and McElwain). Note that clumped isotope thermometry (Quade, Garzione and Eiler) also provides direct estimates of temperature. (4) Radiogenic and cosmogenic nuclides. These 2 chapters cover low-temperature thermochronologic approaches (Reiners) and cosmogenic isotopes (Riihimaki and Libarkin). Some chapters overlap in general content (e.g., basic principles of stable isotopes in precipitation are covered to different degrees in all stable isotope chapters), but no attempt was made to limit authors' discussion of principles, or somehow attempt to arrive at a "consensus view" on any specific topic. Because science advances by critical discussion of concepts, such restrictions were viewed as counterproductive. This does mean that different chapters may present different views on reliability of paleoelevation estimates, and readers are advised to read other chapters in the book on related topics – they may be more closely linked than they might at first appear! I hope readers of this book will discover and appreciate the synergy among paleoaltimetry, climate change, and tectonic geomorphology. These interrelationships create a complex, yet rich field of scientific enquiry that in turn offers insights into climate and geodynamics.
    Pages: Online-Ressource (X, 278 Seiten)
    ISBN: 0939950782
    Language: English
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  • 3
    Publication Date: 2009-10-27
    Print ISSN: 0300-8177
    Electronic ISSN: 1573-4919
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 4
    Publication Date: 2009-08-13
    Description: Current evidence suggests that hematopoietic stem/progenitor cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone marrow. The relative importance and extent to which these pathways overlap or function independently are uncertain. Despite evidence of protease activation in the bone marrow, HSPC mobilization by G-CSF or the chemokine Groβ was abrogated in CXCR4−/− bone marrow chimeras. In contrast, HSPC mobilization by a VLA-4 antagonist was intact. To determine whether other mobilizing cytokines disrupt CXCR4 signaling, we characterized CXCR4 and CXCL12 expression after HSPC mobilization with Flt3 ligand (Flt3L) and stem cell factor (SCF). Indeed, treatment with Flt3L or SCF resulted in a marked decrease in CXCL12 expression in the bone marrow and a loss of surface expression of CXCR4 on HSPCs. RNA in situ and sorting experiments suggested that the decreased CXCL12 expression is secondary to a loss of osteoblast lineage cells. Collectively, these data suggest that disruption of CXCR4 signaling and attenuation of VLA-4 function are independent mechanisms of mobilization by G-CSF. Loss of CXCL12 expression by osteoblast appears to be a common and key step in cytokine-induced mobilization.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2005-07-25
    Print ISSN: 0957-0233
    Electronic ISSN: 1361-6501
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by Institute of Physics
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  • 6
    Publication Date: 2007-11-16
    Description: There is strong evidence that CXCL12 (stromal-derived factor-1)/CXCR4 signaling is a key regulator of hematopoietic stem and progenitor cell (HSPC) trafficking in the bone marrow. CXCL12 protein and mRNA expression in the bone marrow are markedly reduced with G-CSF treatment. We and others recently showed that G-CSF treatment results in a marked loss of mature endosteal and trabecular osteoblasts. Since osteoblasts are a major source of CXCL12, this observation provides a potential mechanism by which G-CSF downregulates CXCL12 expression in the bone marrow. To test this hypothesis, we performed RNA in situ studies for CXCL12. These studies show that CXCL12 is highly expressed in endosteal osteoblasts as well as in scattered cells in the bone marrow in untreated mice. In mice treated with G-CSF, there is a near complete loss of CXCL12 signal along the endosteum. Together, these data suggest a model in which G-CSF induced suppression of osteoblasts leads to a decrease in CXCL12 expression in the bone marrow, disrupting CXCR4 signaling and ultimately leading to HSPC mobilization. This model raises several important questions. Many different hematopoietic cytokines can induce HSPC mobilization. Is loss of CXCL12 expression by osteoblasts a common mechanism by which cytokines induce HSPC mobilization? To address this question, we studied HSPC mobilization by Flt3 ligand (Flt3L) and stem cell factor (SCF), two potent mobilizing hematopoietic cytokines. Treatment with Flt3L or SCF resulted in a significant decrease in bone marrow CXCL12 protein and mRNA expression. Moreover, the decrease in CXCL12 expression was accompanied by a loss in trabecular osteoblasts [number osteoblasts per mm bone ± SEM: 5.1 ± 0.1 (control), 3.1 ± 0.4 (Flt3L), 1.8 ± 0.8 (SCF); n=2, p
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 7
    Publication Date: 2009-10-01
    Print ISSN: 0906-7590
    Electronic ISSN: 1600-0587
    Topics: Biology
    Published by Wiley
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  • 8
  • 9
    Publication Date: 2008-05-01
    Print ISSN: 0003-2697
    Electronic ISSN: 1096-0309
    Topics: Biology , Chemistry and Pharmacology
    Published by Elsevier
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 53 (Oct. 2006), p. 107-115 
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: Bionanotechnology has seen much interest in the past few years. The development innew nanotechnologies and the transfer of such to biomedical applications has been received withlarge expectations. Here we will describe some of the most common techniques to prepare surfaceswith nanometric sized features and how they have been applied to control cell behavior. The focus,however, will be on electron beam lithography and its use in biological applications. We will showthat such highly ordered surfaces exhibit low adhesive properties for cells. Also, such topographieschange the wetting properties to be either more hydrophilic or hydrophobic depending on thesurface energy of the flat surface. Today, little research has found its way to the commercial market.This is mainly down to the ability to make large areas or large quantities of nano patternedmaterials. We will describe a few methods by which we think it would be possible to mass producenano topographically patterned surfaces
    Type of Medium: Electronic Resource
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