ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The double-layered microspheres play an important role in controlling drug delivery forpharmaceutical application, because of the low initial burst compared with single-layered spheresand targetable delivery to specific organ. But it has drawback in loading drug and controlling size.In this study, we developed double-layered spheres using relatively simple oil-in-water (O/W)solvent evaporation method using bovine serum albumin (BSA) as water-soluble protein andpoly(D,L-lactide-co-glycolide) (PLGA). BSA/PLGA double-layered microspheres were fabricatedusing O/W solvent evaporation method and investigated the specific character of double-layeredmicrospheres according to the kind of surfactants. In SEM observation, double layered microspherehad spherical shape and smooth surface without pores. And the double layered microsphere usingO/W solvent evaporation method was transparency because of slow evaporation of solvent. Influorescent observation, we observed the fluorescent core in the double-walled spheres composed ofFITC-BSA and PLGA using fluorescent observation. In the case of polyvinylalcohol as emulsifier,the yield was better than gelatin. As decreased concentration of PLGA, the size of double-layeredmicrospheres deceased
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.513.pdf
Permalink