Publication Date:
2005-06-11
Description:
Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterus. Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with therapies that suppress estrogen production. Many women with endometriosis also suffer from other chronic pain conditions. Recent studies suggest that mechanisms underlying these pains and sensitivity to estrogen involve the growth into the ectopic endometrial tissue of a nerve supply, which could have a varied and widespread influence on the activity of neurons throughout the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berkley, Karen J -- Rapkin, Andrea J -- Papka, Raymond E -- R01 NS11892/NS/NINDS NIH HHS/ -- R01 NS22526/NS/NINDS NIH HHS/ -- R21 DK063937/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1587-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, FL 32306, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947176" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Central Nervous System/*physiology
;
Endometriosis/drug therapy/*physiopathology
;
Female
;
Gonadotropin-Releasing Hormone/agonists
;
Humans
;
Neural Pathways
;
Neurons/*physiology
;
Neurons, Afferent/physiology
;
Pain/*physiopathology
;
Rats
;
Spinal Cord/physiology
;
Sympathetic Nervous System/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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