Publication Date:
2008-07-25
Description:
The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727659/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727659/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Kezhong -- Kaufman, Randal J -- DK042394/DK/NIDDK NIH HHS/ -- HL052173/HL/NHLBI NIH HHS/ -- HL057346/HL/NHLBI NIH HHS/ -- P01 HL057346/HL/NHLBI NIH HHS/ -- P01 HL057346-100006/HL/NHLBI NIH HHS/ -- P01 HL057346-11A18575/HL/NHLBI NIH HHS/ -- R01 DK042394/DK/NIDDK NIH HHS/ -- R01 DK042394-09/DK/NIDDK NIH HHS/ -- R01 HL052173/HL/NHLBI NIH HHS/ -- R01 HL052173-11/HL/NHLBI NIH HHS/ -- R01 HL052173-12/HL/NHLBI NIH HHS/ -- R37 DK042394/DK/NIDDK NIH HHS/ -- R37 DK042394-10/DK/NIDDK NIH HHS/ -- R37 DK042394-11/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Jul 24;454(7203):455-62. doi: 10.1038/nature07203.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, The University of Michigan Medical Center, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18650916" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Disease
;
Endoplasmic Reticulum/metabolism/*pathology
;
Humans
;
Inflammation/metabolism/*pathology
;
JNK Mitogen-Activated Protein Kinases/metabolism
;
NF-kappa B/metabolism
;
Protein Folding
;
Reactive Oxygen Species/metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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