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  • 1
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    Disease but no sheep (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Ping -- Xing, Hongbing -- New York, N.Y. -- Science. 2006 Mar 31;311(5769):1867.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16574852" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; China ; Disease ; History, Ancient ; Linguistics/*history ; Phonetics ; Pruritus/history ; Scrapie/*history ; Sheep
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-02-16
    Description: The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidative phosphorylation into the female mouse germ line. The severe ND6 mutation was selectively eliminated during oogenesis within four generations, whereas the milder COI mutation was retained throughout multiple generations even though the offspring consistently developed mitochondrial myopathy and cardiomyopathy. Thus, severe mtDNA mutations appear to be selectively eliminated from the female germ line, thereby minimizing their impact on population fitness.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049809/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049809/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fan, Weiwei -- Waymire, Katrina G -- Narula, Navneet -- Li, Peng -- Rocher, Christophe -- Coskun, Pinar E -- Vannan, Mani A -- Narula, Jagat -- Macgregor, Grant R -- Wallace, Douglas C -- AG13154/AG/NIA NIH HHS/ -- AG16573/AG/NIA NIH HHS/ -- AG24373/AG/NIA NIH HHS/ -- DK73691/DK/NIDDK NIH HHS/ -- HD45913/HD/NICHD NIH HHS/ -- NS21328/NS/NINDS NIH HHS/ -- U01 HD045913-01/HD/NICHD NIH HHS/ -- U01 HD045913-02/HD/NICHD NIH HHS/ -- U01 HD045913-03/HD/NICHD NIH HHS/ -- U01 HD045913-04/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):958-62. doi: 10.1126/science.1147786.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276892" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiomyopathies/genetics/pathology ; Cell Line ; Crosses, Genetic ; DNA, Mitochondrial/*genetics ; Electron Transport Complex I/metabolism ; Electron Transport Complex IV/*genetics/metabolism ; Embryonic Stem Cells ; Female ; Frameshift Mutation ; *Germ-Line Mutation ; Litter Size ; Male ; Mice ; Mitochondria/physiology ; Mitochondrial Myopathies/*genetics/pathology ; Mutation, Missense ; Myocardium/pathology ; NADH Dehydrogenase/*genetics ; Oocytes/*physiology ; Oogenesis ; Oxidative Phosphorylation ; Oxygen Consumption ; Point Mutation ; *Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Eddy/wind interactions stimulate extraordinary mid-ocean plankton blooms (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-05-19
    Description: Episodic eddy-driven upwelling may supply a significant fraction of the nutrients required to sustain primary productivity of the subtropical ocean. New observations in the northwest Atlantic reveal that, although plankton blooms occur in both cyclones and mode-water eddies, the biological responses differ. Mode-water eddies can generate extraordinary diatom biomass and primary production at depth, relative to the time series near Bermuda. These blooms are sustained by eddy/wind interactions, which amplify the eddy-induced upwelling. In contrast, eddy/wind interactions dampen eddy-induced upwelling in cyclones. Carbon export inferred from oxygen anomalies in eddy cores is one to three times as much as annual new production for the region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGillicuddy, Dennis J Jr -- Anderson, Laurence A -- Bates, Nicholas R -- Bibby, Thomas -- Buesseler, Ken O -- Carlson, Craig A -- Davis, Cabell S -- Ewart, Courtney -- Falkowski, Paul G -- Goldthwait, Sarah A -- Hansell, Dennis A -- Jenkins, William J -- Johnson, Rodney -- Kosnyrev, Valery K -- Ledwell, James R -- Li, Qian P -- Siegel, David A -- Steinberg, Deborah K -- New York, N.Y. -- Science. 2007 May 18;316(5827):1021-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Woods Hole Oceanographic Institution, Woods Hole, MA 02543-1541, USA. dmcgillicuddy@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17510363" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Biomass ; Carbon/analysis ; Chlorophyll/analysis ; Cyanobacteria/growth & development/physiology ; Diatoms/growth & development ; *Ecosystem ; Geologic Sediments ; Oxygen/analysis ; Photosynthesis ; Phytoplankton/growth & development/physiology ; Plankton/*growth & development/physiology ; Seasons ; *Seawater/chemistry ; *Water Movements ; *Wind ; Zooplankton/growth & development/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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