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  • 2005-2009  (255)
  • 1950-1954  (5)
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  • 1
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    Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages (2009)
    American Society of Hematology
    Details
    Publication Date: 2009-03-05
    Description: The processing of pro-interleukin-1β depends on activation of caspase-1. Controversy has arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of interleukin-1β (IL-1β). Here we demonstrate that human blood monocytes release processed IL-1β after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from constitutively activated caspase-1 and release of endogenous adenosine triphosphate. The constitutive activation of caspase-1 depends on the inflammasome components, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and NALP3, but in monocytes caspase-1 activation is uncoupled from pathogen-associated molecular pattern recognition. In contrast, macrophages are unable to process and release IL-1β solely by TLR ligands and require a second adenosine triphosphate stimulation. We conclude that IL-1β production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 2
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    Distribution of branched tetraether lipids in geothermally heated soils: Implications for the MBT/CBT temperature proxy (2009)
    Elsevier
    Details
    Publication Date: 2009-02-01
    Print ISSN: 0146-6380
    Electronic ISSN: 1873-5290
    Topics: Chemistry and Pharmacology , Geosciences
    Published by Elsevier
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  • 3
    Electronic Resource
    Electronic Resource
    High-Rate Fluidized-Bed Ferric Sulfate Generation for Hydrometallurgical Applications (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 20-21 (July 2007), p. 54-57 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: An overview is presented of a multi-year research effort on developing high-ratefluidized-bed bioprocesses for ferric sulfate production to be used as a unit process in varioushydrometallurgical applications including indirect tank leaching of ore concentrates, regenerationof heap leach liquors and control of iron containing acidic mine wastewater. Iron oxidation rates ofover 26 kg m-3 h-1 were achieved at hydraulic retention times of less than 1 h at 37 °C. Oxygensupply became the rate-limiting factor even with 99.5% dioxygen aeration. Fe2+ oxidationproceeded at pH below 1 even in the presence of 60 g Fe3+ L-1 allowing the regeneration ofconcentrated ferric sulphate solutions required in indirect tank leaching of sulfidic ore concentrateapplications. Of several tested FBR carrier materials activated carbon was the most suitable basedon its availability, long-term durability and the achieved high iron oxidation rates. Jarositeprecipitates accumulating to the top of the inert carrier materials played an important role in theFBR biomass retainment. For regeneration of synthetic and actual sulfidic ore heap leachingliquors, a gravity settler was installed in the recycle line of the FBR. The system produced ironprecipitates with good settling characteristics and settling tank effluent with low turbidity andsuspended solids concentrations. These results revealed the potential of FBR process in both heapleach liquor regeneration and controlling the iron containing waste streams. The PCR-DGGE-partialseguencing of the 16S rRNA gene protocol revealed that the FBR culture at 25-37 °C remaineddominated by Leptospirillum ferriphilum over a range of operational conditions studied over theyears. A modeling approach for managing Fe3+ production by FBR in combination with heapleaching was based on an artificial neural network-back propagation algorithm (ANN-HEAP) andresulted in excellent match between the measured and the predicted concentrations. High-ratefluidized-bed iron oxidation is amenable to regeneration of tank and heap leaching solutions as wellas controlling iron containing waste streams
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/39/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.20-21.54.pdf
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Calcium Chloride on Choline Esterase (1953)
    [s.l.] : Nature Publishing Group
    Nature 171 (1953), S. 78-79 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present communication, only the results with calcium chloride will be given, although preliminary experiments with other salts show that the effects observed are by no means specific for calcium chloride. They may be considered as general cation effects. All enzyme activities were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/171078a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A Contrast of HRM and TQM Approaches to Performance Management: Some Evidence (2005)
    Oxford, UK : Blackwell Publishing
    British journal of management 16 (2005), S. 0 
    Details
    ISSN: 1467-8551
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Using a survey, this paper provides information about the current state of performance management (appraisal) from a sample of UK-based EFQM-affiliated organizations. It particularly focuses on several critical issues of performance management in the context of TQM including: the effectiveness of TQM programmes; the rationale for performance management; degree of internal consistency between TQM assumptions and performance management systems; and the relationship among performance management, effectiveness of TQM programmes, employee satisfaction and overall organization performance. Although the fundamental precepts advocated by founders of TQM appear to be in conflict with performance management practices, however, the article argues that, rather than being contradictory, both can add value to the operations of the other in the interest of the organization as a whole. More precisely, the paper explains how a successful TQM strategy requires a rethinking and changing the organization's performance management system, otherwise it is highly likely to result in a disaster. To conclude, the survey evidence is used, combined with previous literature, to discuss the implications of these results for designing a contextually appropriate performance management for TQM and in the interest of the future research on TQM and HRM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-8551.2005.00452.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Competency management and civil service professionalism in Dutch central government (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Public administration 83 (2005), S. 0 
    Details
    ISSN: 1467-9299
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Political Science , Economics
    Notes: Competency management has only recently been introduced into personnel management in Dutch central government. The decentralized nature of Dutch central government and its personnel management systems generates marked variation in the degree to which competency management is being applied across the Dutch civil service. The success or otherwise of competency management schemes in both government departments and the higher civil service in The Netherlands, the Senior Public Service, show mixed results. Although all departments have taken steps in the direction of competency management, a few well-developed programmes are in use. The competency management system of the Senior Public Service, then, serves as a basic tool for its management development programmes. Its aim is to enhance civil service professionalism among senior civil servants. The practical effects of competency management programmes, however, can be questioned. Because competency management links personnel development to pay and career decisions, it could well elicit strategic behaviour by staff members; at worst, it could run the risk of becoming a self-defeating initiative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0033-3298.2005.00479.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Microfabric analysis by manual and automated stereological procedures: a methodological approach to Antarctic tillite (2005)
    Oxford, UK : Blackwell Science Ltd
    Sedimentology 52 (2005), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Fabric analysis is commonly used to infer former movement directions of diamictons; however, analysis techniques are typically time consuming and partly subjective. Stereological analysis provides an alternative for objective determination of the preferred orientation of particles. The ability of manual and automated stereological procedures to determine the preferred orientation of particles (120–4000 µm) in tillite is assessed, using core samples from Mount Feather, McMurdo Dry Valleys, Antarctica. Orthogonal sets of vertical thin sections were subjected to directed secant analysis involving the determination of the number of intersections between particle outlines and a rotating series of parallel lines. The manual analysis reveals a weakly developed three-dimensional tilt angle (plunge) of 68°. This reflects the depth-averaged subglacial deformational structure of the deposit. Because the preferred orientation signal is weak, in the automated set-up this signal is obscured by the effect of digitization, hampering the reliable assessment of the orientation direction. The study shows microfabric variability within the studied cored section that is interpreted as a shear fabric. Reliable macrostructural information that might constrain ice flow directions requires a larger number of randomly or systematically drawn core samples from which averaged microstructural fabrics can be derived.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.2004.00690.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance (2006)
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 650-656 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Here we report the presence of hyperphagia, obesity and insulin resistance in knockout mice deficient in IL-18 or IL-18 receptor, and in mice transgenic for expression of IL-18 binding protein. Obesity of Il18−/− mice resulted from accumulation of fat tissue based on increased food ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1415
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  • 9
    Electronic Resource
    Electronic Resource
    High Speed Fracture Phenomena in Dyneema Composite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 120-125 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Dyneema composite is used in lightweight armour applications, because of its highspecific material properties such as strength and stiffness. In armour applications, Dyneemacomposite is used to protect people or vehicles from projectile impact. In order to be able toguarantee a certain protection level, an accurate prediction of fracture phenomena that are caused byprojectile impact is required. Currently, fracture phenomena such as delamination and fibre fractureare not accurately described. This is because a good understanding of fracture phenomena inDyneema composite lacks. Therefore, both Dyneema fibre and Dyneema composite are analysed bydifferent (impact) experiments to gain more insight in both the fracture phenomena as well as in thematerial properties. Parallel to these experiments, a start is made with the development of a newmaterial model in ABAQUS\Explicit using cohesive zone techniques that is able to predict thefracture phenomena due to projectile impact
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.120.pdf
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  • 10
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    Seismic monitoring at the Sleipner underground CO2 storage site (North Sea) (2007)
    In:  Geological Society Special Publication 233: 181-191.
    Details
    Publication Date: 2007-10-08
    Description: The growing emissions of greenhouse gases, especially CO2, are seen worldwide as one of the major causes of climate change. International treaties like the Kyoto Protocol are supposed to contribute to reducing the emission of greenhouse gases. Underground sequestration has the potential to play an important role in keeping large volumes of CO2 from escaping into the atmosphere in the short term. The first case of industrial scale CO2 storage in the world (close to one million tonnes per year since 1996) is taking place at the Sleipner underground CO2 storage site in the North Sea offshore Norway. Careful monitoring of the behaviour of the storage facility is required to establish its safety. To this end, two time-lapse seismic surveys have been acquired; the first repeat survey was completed in October 1999 and the second in October 2001. The presence of CO2 beneath thin intra-shale layers within the reservoir has caused significant changes both in reflection amplitudes (up to a factor 10) and in travel time (more than 40ms) through the CO2 plume (the velocity push-down effect). Some aspects of the interpretation of these time-lapse seismic surveys will be presented here.
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