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  • 2005-2009  (37)
  • 1970-1974  (106)
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  • 1
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    Molecular biology. The two faces of miRNA (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchan, J Ross -- Parker, Roy -- New York, N.Y. -- Science. 2007 Dec 21;318(5858):1877-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18096794" target="_blank"〉PubMed〈/a〉
    Keywords: *3' Untranslated Regions ; Animals ; Cell Cycle ; *Gene Expression Regulation ; Humans ; MicroRNAs/*metabolism ; *Protein Biosynthesis ; RNA, Messenger/genetics/metabolism ; RNA-Binding Proteins/metabolism ; Tumor Necrosis Factor-alpha/biosynthesis/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-06
    Description: Eukaryotic cells contain nontranslating messenger RNA concentrated in P-bodies, which are sites where the mRNA can be decapped and degraded. We present evidence that mRNA molecules within yeast P-bodies can also return to translation. First, inhibiting delivery of new mRNAs to P-bodies leads to their disassembly independent of mRNA decay. Second, P-bodies decline in a translation initiation-dependent manner during stress recovery. Third, reporter mRNAs concentrate in P-bodies when translation initiation is blocked and resume translation and exit P-bodies when translation is restored. Fourth, stationary phase yeast have large P-bodies containing mRNAs that reenter translation when growth resumes. The reciprocal movement of mRNAs between polysomes and P-bodies is likely to be important in the control of mRNA translation and degradation. Moreover, the presence of related proteins in P-bodies and maternal mRNA storage granules suggests this mechanism is widely adapted for mRNA storage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863069/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863069/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brengues, Muriel -- Teixeira, Daniela -- Parker, Roy -- GM45443/GM/NIGMS NIH HHS/ -- R37 GM045443/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):486-9. Epub 2005 Sep 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721-0106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141371" target="_blank"〉PubMed〈/a〉
    Keywords: DEAD-box RNA Helicases ; Endoribonucleases ; Eukaryotic Initiation Factor-3/genetics/metabolism ; G0 Phase ; Glucose/metabolism ; Organelles/*metabolism ; Polyribosomes/*metabolism ; *Protein Biosynthesis ; RNA Caps/metabolism ; RNA Helicases/metabolism ; RNA, Fungal/*metabolism ; RNA, Messenger/*metabolism ; RNA-Binding Proteins/metabolism ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/cytology/genetics/*metabolism ; Saccharomyces cerevisiae Proteins/biosynthesis/genetics/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Coastal Ocean Benthic Observatories (COBO): Integrated tools for the in situ observation and study of benthic ecosystem biogeochemical processes (2005)
    In:  EPIC3Abstracts of papers of the American Chemical Society, pp. 1791-1792, ISSN: 0065-7727
    Details
    Publication Date: 2014-09-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 4
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    Integrating new technologies for the study of benthic ecosystems response to human activity: towards a coastal ocean benthic observatory (COBO) (2008)
    In:  EPIC3Proceedings of the Italian Association of Oceanology and Limnology, 19, pp. 73-78
    Details
    Publication Date: 2014-09-17
    Repository Name: EPIC Alfred Wegener Institut
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  • 5
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    Coastal Ocean Benthic Observatories (COBO): Integrated tools for the in-situ observation and study of benthic ecosystem biogeochemical processes (Vortrag) (2005)
    In:  EPIC3In-situ Methods and Investigations in Environmental Science, 230th Meeting of the American Chemical Society, Division of Geochemistry, Washington, DC, USA.08.-01.09.2005., 28
    Details
    Publication Date: 2014-09-17
    Description: Marine coastal ecosystems, and in particular the sedentary benthic invertebrate communities that play a critical role in regulating coastal geochemical cycles, are compromised by human-induced stresses, including overfishing, habitat destruction, climate change and pollution. However, due to the complexity, remoteness and spatio-temporal variability of this environment, the relationships between tightly coupled biological, physical and geochemical processes are poorly understood. The combination in COBO of innovative in situ measurement instruments from different disciplines with tools for the controlled simulation of various disturbance types and numerical tools for the interpretation of new forms of in situ data will significantly advance our understanding of organism-sediment interactions under dynamic coastal conditions. Integrated observations of the natural environment at high spatial and temporal resolution enable a quantitative and mechanistic understanding of the fundamental processes governing the interaction between the biota and its chemical environment, enabling the informed management of human impacts on coastal ecosystems.
    Repository Name: EPIC Alfred Wegener Institut
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  • 6
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    Predicting benthic ecosystem response to anthropogenic perturbations: the Coastal Ocean Benthic Observatory (COBO) approach (Vortrag) (2005)
    In:  EPIC3Estuarine & Coastal Sciences Association (ECSA) meeting, Edinburgh, Scotland.-07.09.2005., 05
    Details
    Publication Date: 2014-09-17
    Description: Marine coastal ecosystems are among the most productive and diverse communities on Earth and are of global importance to climate, nutrient budgets, and primary productivity. Yet, these ecosystems, and in particular sedentary benthic (bottom-living) invertebrate communities at their base, are compromised by human-induced stresses, including overfishing, habitat destruction, and pollution. Emerging environmental legislation such as the Water Framework Directive (WFD) has the potential to significantly improve the ecological status of Europes aquatic ecosystems, from rivers to the sea. However, depending upon how it is interpreted and implemented, it has the potential to impact many activities in coastal systems, including flood defence, coastal development, dredging, aquaculture and fishing. There is a critical need for a set of biogeochemical measures to assist in the characterisation of ecological function, status and potential in coastal benthic ecosystems. The FP6-funded Coastal Ocean Benthic Observatories (COBO, http://www.cobo.org.uk) program integrates in situ technologies to monitor benthic habitats, in order to understand how anthropogenic impacts affect benthic ecosystem functioning. As a complement to blind, synoptic sampling and laboratory studies, in situ studies provide rigorous scientific insight into the interactions between the biota (function and diversity) and their chemical and physical environment and the processes regulating this habitat within the context of dynamic processes that occur over many spatial and temporal scales. COBO allows for interdisciplinary, in situ observation and experimentation in these complex, remote and poorly understood ecosystems, both providing fundamental understanding of the interactions between the biota and their environment and facilitating informed management of human impacts on coastal ecosystems. Conceptual frameworks and communication tools are being developed using visualisation software, advanced numerical tools and a DPSIR approach to link scientific results with policy, measures and approaches for coastal ecosystem management.
    Repository Name: EPIC Alfred Wegener Institut
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  • 7
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    Integrating new technologies for the study of benthic ecosystem response to human activity: Towards a Coastal Ocean Benthic Observatory (COBO) (Poster) (2006)
    In:  EPIC3XVII Congress of the Italian Association of Oceanology and Limnology, Napoli, Italia.-07.07.2006., 03
    Details
    Publication Date: 2014-09-17
    Description: Coastal ecosystems are particularly vulnerable to anthropogenic perturbation, affecting biodiversity and ecosystem stability and resilience. Shallow water sediments and their associated biota represent a reservoir for biodiversity, hosting resting and reproductive stages of planktonic organisms, and regulating carbon and nutrient biogeochemical cycles. However, the relationship between tightly coupled biological and geochemical processes in this environment is poorly defined with respect to their temporal and spatial variability.The overall objective of COBO is to integrate emerging and innovative technologies from different disciplines (physics, chemistry, biology, imagery) to provide in situ monitoring of sediment habitats, a key component of coastal marine ecosystems, in order to understand complex interactions between the biota (function and diversity) and their chemical environment. Existing technologies have limited spatial and temporal sampling resolutions which has hampered progress in determining key parameters and, in explaining biogeochemical patterns / processes and in modelling ecosystem dynamics. Improved in situ technologies are required to provide rigorous scientific information on processes regulating this unique and fragile habitat and for assessing, controlling and minimising human impact on European coastal waters. The combination of innovative instruments from different scientific disciplines will provide powerful tools to significantly advance our understanding of organism -sediment relations under dynamic coastal conditions and enhance predictive capability.The main activity of COBO is:- Integration of sediment profile imagery (SPI) and Optodes for their simultaneous deployment. This will then allow for the measurement of bi-dimensional fields of oxygen with a visual link to macrofaunal movement.- Development of a scale integrated sediment disturber which working area will be monitored continuously using digital cameras and micro-profilers with oxygen microelectrodes and, at the start and end points, by examining sediment cores.- Development of a chamber capable of regulating oxygen (oxystat) equipped with nitrate sensors.- Integration of manipulated benthic chambers capable of particle and liquid addition and sediment resuspension.- Development of smart and adaptable systems integrating control electronics capable of reaction to external events.- Development of numerical tools consisting of building 2D models of early diagenesis and sediment-organism relationship.
    Repository Name: EPIC Alfred Wegener Institut
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  • 8
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    COBO Science - Supporting European Ecosystem-based Coastal Management (2007)
    In:  EPIC3Coastal Ocean Benthic Observatories (COBO) Newsletter, Year 3, Quarter 4. {http://www.cobo.org.uk/Documents/COBO_y3q4_newsletter.pdf}, 1
    Details
    Publication Date: 2014-09-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Miscellaneous , notRev
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  • 9
    Electronic Resource
    Electronic Resource
    On the comprehensive nature of R & D (1972)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 3 (1972), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1972.tb00995.x
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  • 10
    Electronic Resource
    Electronic Resource
    Hendriksen's Accounting Theory1 (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Abacus 8 (1972), S. 0 
    Details
    ISSN: 1467-6281
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6281.1972.tb00389.x
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