ISSN:
1013-9826
Quelle:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Thema:
Maschinenbau
Notizen:
The effect of different hydroxyapatite particles on malignant melanoma cell wasevaluated in vitro. Two kinds of short-rode hydroxyapatite particles, which range from 0.4 to 1 umand 0.5 to 1.5 um, were co-cultured with human’s malignant melanoma (MM) cell line A375 for 24,48, and 72 h. Both of these HA particles showed the same cell proliferation rate as blank control,and there was no statistically significant correlation of matrix metalloproteinases-2 (MMP-2)expression to the HA particle size. SEM images showed that the membrane of tumor cell, whichco-cultured with HA particles, was shrunk. The cell superficial sentus was reduced and small sizeparticle’ effect was more obvious. Since immunohistochemistry and SEM data are qualitativetechnique, further precise methods might bring more information about the effect of HA particles ontumor behaviors. But this study can provide the bio-security test of micrometer HA particles intransplantation after tumor excision
Materialart:
Digitale Medien
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.761.pdf
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