Publication Date:
2019
Description:
〈p〉Cross-linking of high-affinity IgE results in the life-threatening allergic reaction, anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE to allergens remain poorly understood. T follicular helper (Tfh) cells direct the affinity and isotype of antibodies produced by B cells. Although Tfh cell-derived IL-4 is necessary for IgE production, it is not sufficient. We report a rare population of IL-13-producing Tfh cells present in mice and humans with IgE to allergens, but not when allergen-specific IgE was absent or only low-affinity. These "Tfh13" cells have an unusual cytokine profile (IL-13〈sup〉hi〈/sup〉IL-4〈sup〉hi〈/sup〉IL-5〈sup〉hi〈/sup〉IL-21〈sup〉lo〈/sup〉) and co-express BCL6 and GATA3. They were required for production of high- but not low-affinity IgE and subsequent allergen-induced anaphylaxis. Blocking Tfh13 cells may represent an alternative therapeutic target to ameliorate anaphylaxis.〈/p〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Natural Sciences in General
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