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  • 2015-2019  (2,183)
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  • 1
    Call number: ZSP-599-150
    In: Rapportserie / Norsk Polarinstitutt, (DE-B103)114733
    Type of Medium: Series available for loan
    Pages: 325 Seiten , Illustrationen, Karten, Diagramme
    ISBN: 9788276664119 , 9788276664126
    Series Statement: Rapportserie / Norsk Polarinstitutt nr. 150
    Language: Norwegian
    Note: In norwegischer Sprache
    Location: AWI Reading room
    Branch Library: AWI Library
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  • 2
    Monograph available for loan
    Monograph available for loan
    Amsterdam : Elsevier
    Call number: M 18.91612
    Description / Table of Contents: Front Cover -- Machine Learning Techniques for Space Weather -- Copyright -- Contents -- Contributors -- Introduction -- Machine Learning and Space Weather -- Scope and Structure of the Book -- Acknowledgments -- References -- Part I: Space Weather -- Chapter 1: Societal and Economic Importance of Space Weather -- 1 What is Space Weather? -- 2 Why Now? -- 3 Impacts -- 3.1 Geomagnetically Induced Currents -- 3.2 Global Navigation Satellite Systems -- 3.3 Single-Event Effects -- 3.4 Other Radio Systems -- 3.5 Satellite Drag -- 4 Looking to the Future -- 5 Summary and Conclusions -- Acknowledgments -- References -- Chapter 2: Data Availability and Forecast Products for Space Weather -- 1 Introduction -- 2 Data and Models Based on Machine Learning Approaches -- 3 Space Weather Agencies -- 3.1 Government Agencies -- 3.1.1 NOAA's Data and Products -- 3.1.2 NASA -- 3.1.3 European Space Agency -- 3.1.4 The US Air Force Weather Wing -- 3.2 Academic Institutions -- 3.2.1 Kyoto University, Japan -- 3.2.2 Rice University, USA -- 3.2.3 Laboratory for Atmospheric and Space Physics, USA -- 3.3 Commercial Providers -- 3.4 Other Nonprofit, Corporate Research Agencies -- 3.4.1 USGS -- 3.4.2 JHU Applied Physics Lab -- 3.4.3 US Naval Research Lab -- 3.4.4 Other International Service Providers -- 4 Summary -- References -- Part II: Machine Learning -- Chapter 3: An Information-Theoretical Approach to Space Weather -- 1 Introduction -- 2 Complex Systems Framework -- 3 State Variables -- 4 Dependency, Correlations, and Information -- 4.1 Mutual Information as a Measure of Nonlinear Dependence -- 4.2 Cumulant-Based Cost as a Measure of Nonlinear Dependence -- 4.3 Causal Dependence -- 4.4 Transfer Entropy and Redundancy as Measures of Causal Relations -- 4.5 Conditional Redundancy -- 4.6 Significance of Discriminating Statistics
    Description / Table of Contents: 4.7 Mutual Information and Information Flow -- 5 Examples From Magnetospheric Dynamics -- 6 Significance as an Indicator of Changes in Underlying Dynamics -- 6.1 Detecting Dynamics in a Noisy System -- 6.2 Cumulant-Based Information Flow -- 7 Discussion -- 8 Summary -- Acknowledgments -- References -- Chapter 4: Regression -- 1 What is Regression? -- 2 Learning From Noisy Data -- 2.1 Prediction Errors -- 2.2 A Probabilistic Set-Up -- 2.3 The Least Squares Method for Linear Regression -- 2.3.1 The Least Squares Method and the Best Linear Predictor -- 2.3.2 The Least Squares Method and the Maximum Likelihood Principle -- 2.3.3 A More General Approach and Higher-Order Predictors -- 2.4 Overfitting -- 2.4.1 The Order Selection Problem -- Error Decomposition: The Bias Versus Variance Trade-Off -- Some Popular Order Selection Criteria -- 2.4.2 Regularization -- 2.5 From Point Predictors to Interval Predictors -- 2.5.1 Distribution-Free Interval Predictors -- 2.6 Probability Density Estimation -- 3 Predictions Without Probabilities -- 3.1 Approximation Theory -- Dense Sets -- Best Approximator -- 3.1.1 Neural Networks -- The Backpropagation Algorithm: High-Level Idea -- Multiple Layers Networks (Deep Networks) -- 4 Probabilities Everywhere: Bayesian Regression -- 4.1 Gaussian Process Regression -- 5 Learning in the Presence of Time: Identification of Dynamical Systems -- 5.1 Linear Time-Invariant Systems -- 5.2 Nonlinear Systems -- References -- Chapter 5: Supervised Classification: Quite a Brief Overview -- 1 Introduction -- 1.1 Learning, Not Modeling -- 1.2 An Outline -- 2 Classifiers -- 2.1 Preliminaries -- 2.2 The Bayes Classifier -- 2.3 Generative Probabilistic Classifiers -- 2.4 Discriminative Probabilistic Classifiers -- 2.5 Losses and Hypothesis Spaces -- 2.5.1 0-1 Loss -- 2.5.2 Convex Surrogate Losses
    Description / Table of Contents: 2.5.3 Particular Surrogate Losses -- 2.6 Neural Networks -- 2.7 Neighbors, Trees, Ensembles, and All that -- 2.7.1 k Nearest Neighbors -- 2.7.2 Decision Trees -- 2.7.3 Multiple Classifier Systems -- 3 Representations and Classifier Complexity -- 3.1 Feature Transformations -- 3.1.1 The Kernel Trick -- 3.2 Dissimilarity Representation -- 3.3 Feature Curves and the Curse of Dimensionality -- 3.4 Feature Extraction and Selection -- 4 Evaluation -- 4.1 Apparent Error and Holdout Set -- 4.2 Resampling Techniques -- 4.2.1 Leave-One-Out and k-Fold Cross-Validation -- 4.2.2 Bootstrap Estimators -- 4.2.3 Tests of Significance -- 4.3 Learning Curves and the Single Best Classifier -- 4.4 Some Words About More Realistic Scenarios -- 5 Regularization -- 6 Variations on Standard Classification -- 6.1 Multiple Instance Learning -- 6.2 One-Class Classification, Outliers, and Reject Options -- 6.3 Contextual Classification -- 6.4 Missing Data and Semisupervised Learning -- 6.5 Transfer Learning and Domain Adaptation -- 6.6 Active Learning -- Acknowledgments -- References -- Part III: Applications -- Chapter 6: Untangling the Solar Wind Drivers of the Radiation Belt: An Information Theoretical Approach -- 1 Introduction -- 2 Data Set -- 3 Mutual Information, Conditional Mutual Information, and Transfer Entropy -- 4 Applying Information Theory to Radiation Belt MeV Electron Data -- 4.1 Radiation Belt MeV Electron Flux Versus Vsw -- 4.2 Radiation Belt MeV Electron Flux Versus nsw -- 4.3 Anticorrelation of Vsw and nsw and Its Effect on Radiation Belt -- 4.4 Ranking of Solar Wind Parameters Based on Information Transfer to Radiation Belt Electrons -- 4.5 Detecting Changes in the System Dynamics -- 5 Discussion -- 5.1 Geo-Effectiveness of Solar Wind Velocity -- 5.2 nsw and Vsw Anticorrelation
    Description / Table of Contents: 5.3 Geo-Effectiveness of Solar Wind Density -- 5.4 Revisiting the Triangle Distribution -- 5.5 Improving Models With Information Theory -- 5.5.1 Selecting Input Parameters -- 5.5.2 Detecting Nonstationarity in System Dynamics -- 5.5.3 Prediction Horizon -- 6 Summary -- Acknowledgments -- References -- Chapter 7: Emergence of Dynamical Complexity in the Earth's Magnetosphere -- 1 Introduction -- 2 On Complexity and Dynamical Complexity -- 3 Coherence and Intermittent Features in Time Series Geomagnetic Indices -- 4 Scale-Invariance and Self-Similarity in Geomagnetic Indices -- 5 Near-Criticality Dynamics -- 6 Multifractional Features and Dynamical Phase Transitions -- 7 Summary -- Acknowledgments -- References -- Chapter 8: Applications of NARMAX in Space Weather -- 1 Introduction -- 2 NARMAX Methodology -- 2.1 Forward Regression Orthogonal Least Square -- 2.2 The Noise Model -- 2.3 Model Validation -- 2.4 Summary -- 3 NARMAX and Space Weather Forecasting -- 3.1 Geomagnetic Indices -- 3.1.1 SISO Dst Index -- 3.1.2 Continuous Time Dst model -- 3.1.3 MISO Dst -- 3.1.4 Kp Index -- 3.2 Radiation Belt Electron Fluxes -- 3.2.1 GOES High Energy -- 3.2.2 SNB3GEO Comparison With NOAA REFM -- 3.2.3 GOES Low Energy -- 3.3 Summary of NARMAX Models -- 4 NARMAX and Insight Into the Physics -- 4.1 NARMAX Deduced Solar Wind-Magnetosphere Coupling Function -- 4.2 Identification of Radiation Belt Control Parameters -- 4.2.1 Solar Wind Density Relationship With Relativistic Electrons at GEO -- 4.2.2 Geostationary Local Quasilinear Diffusion vs. Radial Diffusion -- 4.3 Frequency Domain Analysis of the Dst Index -- 5 Discussions and Conclusion -- References -- Chapter 9: Probabilistic Forecasting of Geomagnetic Indices Using Gaussian Process Models -- 1 Geomagnetic Time Series and Forecasting -- 2 Dst Forecasting
    Description / Table of Contents: 2.1 Models and Algorithms -- 2.2 Probabilistic Forecasting -- 3 Gaussian Processes -- 3.1 Gaussian Process Regression: Formulation -- 3.2 Gaussian Process Regression: Inference -- 4 One-Hour Ahead Dst Prediction -- 4.1 Data Source: OMNI -- 4.2 Gaussian Process Dst Model -- 4.3 Gaussian Process Auto-Regressive (GP-AR) -- 4.4 GP-AR With eXogenous Inputs (GP-ARX) -- 5 One-Hour Ahead Dst Prediction: Model Design -- 5.1 Choice of Mean Function -- 5.2 Choice of Kernel -- 5.3 Model Selection: Hyperparameters -- 5.3.1 Grid Search -- 5.3.2 Coupled Simulated Annealing -- 5.3.3 Maximum Likelihood -- 5.4 Model Selection: Auto-Regressive Order -- 6 GP-AR and GP-ARX: Workflow Summary -- 7 Practical Issues: Software -- 8 Experiments and Results -- 8.1 Model Selection and Validation Performance -- 8.2 Comparison of Hyperparameter Selection Algorithms -- 8.3 Final Evaluation -- 8.4 Sample Predictions With Error Bars -- 9 Conclusion -- References -- Chapter 10: Prediction of MeV Electron Fluxes and Forecast Verification -- 1 Relativistic Electrons in Earth's Outer Radiation Belt -- 1.1 Source, Loss, Transport, and Acceleration, Variation -- 2 Numerical Techniques in Radiation Belt Forecasting -- 3 Relativistic Electron Forecasting and Verification -- 3.1 Forecast Verification -- 3.2 Relativistic Electron Forecasting -- 4 Summary -- References -- Chapter 11: Artificial Neural Networks for Determining Magnetospheric Conditions -- 1 Introduction -- 2 A Brief Review of ANNs -- 3 Methodology and Application -- 3.1 The DEN2D Model -- 4 Advanced Applications -- 4.1 The DEN3D Model -- 4.2 The Chorus and Hiss Wave Models -- 4.3 Radiation Belt Flux Modeling -- 5 Summary and Discussion -- Acknowledgments -- References -- Chapter 12: Reconstruction of Plasma Electron Density From Satellite Measurements Via Artificial Neural Networks
    Description / Table of Contents: 1 Overview
    Type of Medium: Monograph available for loan
    Pages: xviii, 433 Seiten , Illustrationen
    ISBN: 978-0-12-811788-0
    Classification:
    Geophysics
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 3
    Publication Date: 2016-09-19
    Description: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with a unique geographical distribution. The genomic abnormalities leading to NPC pathogenesis remain unclear. In total, 135 NPC tumors were examined to characterize the mutational landscape using whole-exome sequencing and targeted resequencing. An APOBEC cytidine deaminase mutagenesis signature was revealed in the somatic mutations. Noticeably, multiple loss-of-function mutations were identified in several NF-κB signaling negative regulators NFKBIA, CYLD, and TNFAIP3. Functional studies confirmed that inhibition of NFKBIA had a significant impact on NF-κB activity and NPC cell growth. The identified loss-of-function mutations in NFKBIA leading to protein truncation contributed to the altered NF-κB activity, which is critical for NPC tumorigenesis. In addition, somatic mutations were found in several cancer-relevant pathways, including cell cycle-phase transition, cell death, EBV infection, and viral carcinogenesis. These data provide an enhanced road map for understanding the molecular basis underlying NPC.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2015-11-01
    Print ISSN: 0378-1119
    Electronic ISSN: 1879-0038
    Topics: Biology
    Published by Elsevier
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  • 5
  • 6
    Publication Date: 2019
    Description: Abstract The dynamics of freeze and thaw events in Antarctic sea ice impart chemical changes in the underlying sea water. Trace metals in sea ice and accumulated through deposition of dust are released into sea water as sea ice breaks up in spring. Clams such as Laternula elliptica incorporate a record of these and associated chemical dynamics in their carbonate shells. In 2012, we collected samples of L. elliptica from three sites along a sea ice persistence gradient in McMurdo Sound, Ross Sea Antarctica. Concentrations of trace metals in the chondrophore of each shell were measured by laser ablation inductively coupled plasma mass spectrometry. Ablations transected annual growth increments creating time series ranging in length from 13 to 25 yr. An 8‐yr time period of persistent sea ice, associated with presence of the B‐15 and C‐19 icebergs at the entrance of McMurdo Sound, was clearly resolved in the trace element time series. Conservative trace metals (Sr, Ba) were found at higher concentrations, and highly scavenged elements (Pb, Cu) were found at lower concentrations at sites with more persistent sea ice and during the 8‐yr period of iceberg‐influenced sea ice persistence. Bioactive trace metals (Fe, Ni) were found in higher concentrations during ice free conditions, associated with a period of high pelagic productivity. Our results provide an important case study for understanding the chemical signature of changing sea ice dynamics as reflected in bivalve shell material under a changing Antarctic climate.
    Print ISSN: 0024-3590
    Electronic ISSN: 1939-5590
    Topics: Biology , Geosciences , Physics
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  • 7
    Publication Date: 2016-03-07
    Description: Multiple factors, including host genetics, environmental factors, and Epstein–Barr virus (EBV) infection, contribute to nasopharyngeal carcinoma (NPC) development. To identify genetic susceptibility genes for NPC, a whole-exome sequencing (WES) study was performed in 161 NPC cases and 895 controls of Southern Chinese descent. The gene-based burden test discovered an association between macrophage-stimulating 1 receptor (MST1R) and NPC. We identified 13 independent cases carrying the MST1R pathogenic heterozygous germ-line variants, and 53.8% of these cases were diagnosed with NPC aged at or even younger than 20 y, indicating that MST1R germ-line variants are relevant to disease early-age onset (EAO) (age of ≤20 y). In total, five MST1R missense variants were found in EAO cases but were rare in controls (EAO vs. control, 17.9% vs. 1.2%, P = 7.94 × 10−12). The validation study, including 2,160 cases and 2,433 controls, showed that the MST1R variant c.G917A:p.R306H is highly associated with NPC (odds ratio of 9.0). MST1R is predominantly expressed in the tissue-resident macrophages and is critical for innate immunity that protects organs from tissue damage and inflammation. Importantly, MST1R expression is detected in the ciliated epithelial cells in normal nasopharyngeal mucosa and plays a role in the cilia motility important for host defense. Although no somatic mutation of MST1R was identified in the sporadic NPC tumors, copy number alterations and promoter hypermethylation at MST1R were often observed. Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of the MST1R-mediated signaling pathways.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2015-06-20
    Description: We assessed the Chinese version of the Drug Abuse Screening Test (DAST-10) for identifying illicit drug use during pregnancy among Chinese population. Chinese pregnant women attending their first antenatal visit or their first unbooked visit to the maternity ward were recruited during a 4-month study period in 2011. The participants completed self-administered questionnaires on demographic information, a single question on illicit drug use during pregnancy and the DAST-10. Urine samples screened positive by the urine Point-of-Care Test were confirmed by gas chromatography-mass spectrometry. DAST-10 performance was compared with three different gold standards: urinalysis, self-reported drug use, and evidence of drug use by urinalysis or self-report. 1214 Chinese pregnant women participated in the study and 1085 complete DAST-10 forms were collected. Women who had used illicit drugs had significantly different DAST-10 scores than those who had not. The sensitivity of DAST-10 for identify illicit drug use in pregnant women ranged from 79.2% to 33.3% and specificity ranged from 67.7% to 99.7% using cut-off scores from ≥1 to ≥3. The ~80% sensitivity of DAST-10 using a cut-off score of ≥1 should be sufficient for screening of illicit drug use in Chinese pregnant women, but validation tests for drug use are needed. Scientific Reports 5 doi: 10.1038/srep11420
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 9
    Publication Date: 2015-06-12
    Description: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). To identify recipient risk factors, a genome-wide study was performed including 481,820 single-nucleotide polymorphisms (SNPs). Two GVHD susceptibility loci (rs17114803 and rs17114808) within the SUFU gene were identified in the discovery cohort (p = 2.85 × 10−5). The incidence of acute GVHD among patients homozygous for CC at SUFU rs17114808 was 69%, which was significantly higher than the 8% rate observed in CT heterozygous patients (p = 0.0002). In an independent validation cohort of 100 patients, 50% of the patients with the CC genotype developed GVHD compared to 8% of the patients with either CT or TT genotype (p = 0.01). In comparison to CC dendritic cells, those from CT expressed higher levels of SUFU mRNA and protein, had lower levels of surface HLA-DR, and induced less allogeneic mixed leukocyte response (MLR). Ectopic expression of SUFU in THP-1 derived DCs reduced HLA-DR expression and suppressed MLR, whereas silencing of SUFU enhanced HLA-DR expression and increased MLR. Thus our findings provide novel evidence that recipient SUFU germline polymorphism is associated with acute GVHD and is a novel molecular target for GVHD prevention and treatment. Scientific Reports 5 doi: 10.1038/srep11098
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 10
    Publication Date: 2019
    Description: This study examines the sustainability of financial integration between China (represented by Shenzhen and Shanghai) stock markets and Hong Kong stock market over the period of pre and post launch of the Stock Connect Scheme. This paper aims to fill the gap in the financial literature by providing empirical research on the dynamics of the financial integration process, and examining the sustainability of financial integration among the three Chinese stock markets. We apply cointegration and both linear and nonlinear causalities to investigate whether the Shanghai–Hong Kong Stock Connect has any impact on both market capitalizations and market indices of Hong Kong, Shanghai, and Shenzhen markets. Through cointegration tests and linear Granger causality techniques, it was found that the stock markets from mainland China are increasingly influencing the Hong Kong stock market after the introduction of the Stock Connect Scheme; however, when using nonlinear Granger causality analysis for confirming China market dominance, the result shows an reverse relationship whereby the Hong Kong stock market is still relevant to understand and predict China stock market after the introduction of the Stock Connect Scheme. Overall, our findings support the view that the Shanghai–Hong Kong Stock Connect has a significant impact on both market capitalizations and market indices of the Hong Kong, Shanghai, and Shenzhen markets, but Hong Kong stock market is still relevant to understand and predict China stock market after the introduction of the Stock Connect Scheme. The change in share premium difference between mainland China’s domestic A-share markets and Hong Kong’s H-share market could change investors’ appetites or sentiments. Further research includes examining whether there is any functional relationship including nonlinear relationship and studying the dynamic drivers of the relationships.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI
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