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  • 2020-2024  (187)
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  • 1
    Keywords: Pharmaceutical chemistry. ; Pharmacology. ; Clinical biochemistry. ; Pharmaceutics. ; Pharmacology. ; Medical Biochemistry.
    Description / Table of Contents: Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs -- Optimizing the Formulation of Poorly Water-Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle-Size Reduction Techniques -- Co-solvent and Complexation Systems -- Injectable Formulations of Poorly Water-Soluble Drugs -- Lipid-Based Formulations -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray-Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs -- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
    Abstract: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
    Type of Medium: Online Resource
    Pages: XII, 693 p. 280 illus., 138 illus. in color. , online resource.
    Edition: 3rd ed. 2022.
    ISBN: 9783030887193
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 50
    DDC: 615.19
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Ecology . ; Conservation biology. ; Zoology. ; Biodiversity. ; Ecology. ; Conservation Biology. ; Zoology. ; Biodiversity.
    Description / Table of Contents: Introduction -- Part I. Ethology and Behavioral Ecology of Sea Otters -- Taxonomy and Evolution of Sea Otters -- Sea Otter Behavior: Morphologic, Physiologic, and Sensory Adaptations -- Sea Otter Foraging Behavior -- Social Structure of Marine Otters: Inter and Intraspecific Variation -- Reproductive Behavior of Male Sea Otters -- Reproductive Behavior of Female Sea Otters and Their Pups -- Sea Otter Behavior and Its Influence on Littoral Community Structure -- Sea Otter Predator Avoidance Behavior -- Sea Otters and the Maritime Fur Trade -- Part II. Ethology and Behavioral Ecology of Polar Bears -- Polar Bear Taxonomy and Evolution -- Polar Bear Behavior: Morphologic and Physiologic Adaptations -- Polar Bear Foraging Behavior -- Polar Bear Reproductive and Denning Behavior -- Polar Bear Maternal Care, Neonatal Development, and Social Behavior -- Polar Bear Behavior in Response to Climate Change -- Human-Polar Bear Interactions.
    Abstract: Sea otters and polar bears are carnivorous marine mammals that still resemble their terrestrial ancestors. Compared with Cetacea (whales and dolphins), Sirenia (dugongs and manatees), and Pinnipedia (seals, sea lions, and walrus), they are less adapted for an aquatic life and the most recently evolved among marine mammals. Sea otters are amphibious but seldom come ashore, and polar bears primarily occur on sea ice or along the shore. When at sea, both species spend most of their time swimming at the surface or making short, shallow dives when foraging or pursuing prey. Indeed, polar bears rarely pursue seals in water. Nevertheless, polar bears are powerful swimmers and will stalk seals from the water. As with many other large carnivores, they are solitary hunters. Although sea otters are gregarious and form aggregations at sea called rafts, they are primarily asocial. Except during mating, the principal interaction among sea otters occurs between a female and offspring during the six-month dependency period. In large carnivores (e.g., wolves and lions) that feed on ungulates, sociality and cooperation are favored because of the need to capture large prey and defend carcasses. Polar bears, which are the largest terrestrial carnivore, are solitary hunters of seals and are neither gregarious nor social. Males and females briefly associate during courtship and mating. During this time, males aggressively compete for females. At other times, males generally avoid each other except for aggregations of males that form while summering on land, and females with cubs avoid males, which are known for infanticide. As with sea otters, the interaction of polar bears outside of mating occurs between a female and her offspring during the 2-3 year dependency period. This interaction is critically important when altricial cubs are born in the winter den. This book provides new insight into the ethology and behavioral ecology of sea otters and polar bears. Each chapter reviews the discoveries of previous studies and integrates recent research using new techniques and technology. The authors also address historic and current anthropogenic challenges for their survival as climate change alters entire marine ecosystems.
    Type of Medium: Online Resource
    Pages: XIV, 363 p. 110 illus., 89 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030667962
    Series Statement: Ethology and Behavioral Ecology of Marine Mammals,
    DDC: 577
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cartography. ; Geographic information systems. ; Geophysics. ; Cartography. ; Geographical Information System. ; Geophysics.
    Description / Table of Contents: Russian and Soviet Cartography: A Concise History -- An Introduction to Soviet Military City Plans -- Towards an Ontogenetic Approach to Soviet Military City Plans: a Post-Representational Epistemology -- Developing an Approach to Analysing Soviet City Plans -- The Methodology -- Analysing the Symbology of Soviet Military City Plans -- Discussion.
    Abstract: The collapse of the Soviet Union has seen the emergence of its unprecedentedly comprehensive global secret military mapping project and the commercial availability of a vast number of detailed topographic maps and city plans at several scales. This thesis provides an in-depth examination of the series of over 2,000 large-scale city plans produced in secret by the Military Topographic Directorate (Военное топографическое управление) of the General Staff between the end of the Second World War and the collapse of the USSR in 1991. After positioning the series in its historical context, the nature and content of the plans are examined in detail. A poststructuralist perspective introduces possibilities to utilise and apply the maps in new contexts, which this thesis facilitates by providing a systematic, empirical analysis of the Soviet map symbology at 1:10,000 and 1:25,000, using new translations of production manuals and a sample of the city plans. A comparative analysis with the current OpenStreetMap symbology indicates scope for Soviet mapping to be used as a valuable supplementary topographic resource in a variety of existing and future global mapping initiatives, including humanitarian crisis mapping. This leads to a conclusion that the relevance and value of Soviet military maps endure in modern applications, both as a source of data and as a means of overcoming contemporary cartographic challenges relating to symbology, design and the handling of large datasets. .
    Type of Medium: Online Resource
    Pages: XXII, 200 p. 97 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840174
    Series Statement: Springer Theses, Recognizing Outstanding Ph.D. Research,
    DDC: 526
    Language: English
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  • 4
    Publication Date: 2023-11-14
    Description: Simulating magma propagation pathways requires both a well‐calibrated model for the stress state of the volcano and models for dike advance within such a stress field. Here, we establish a framework for calculating computationally efficient and flexible magma propagation scenarios in the presence of caldera structures. We first develop a three‐dimensional (3D) numerical model for the stress state at volcanoes with mild topography, including the stress induced by surface loads and unloading due to the formation of caldera depressions. Then, we introduce a new, simplified 3D model of dike propagation. Such a model captures the complexity of 3D magma trajectories with low running time, and can backtrack dikes from a vent to the magma storage region. We compare the new dike propagation model to a previously published 3D model. Finally, we employ the simplified model to produce shallow dike propagation scenarios for a set of synthetic caldera settings with increasingly complex topographies. The resulting synthetic magma pathways and eruptive vent locations broadly reproduce the variability observed in natural calderas.
    Description: Plain Language Summary: Understanding the pathways that bring magma from an underground chamber to the surface helps to prepare for future eruptions in volcanic areas. Dikes are fractures filled with magma and represent the most common mechanism of magma transport in the Earth's crust. Their trajectories may be curved if the Earth's crust is deformed by the load of topography or by tectonic forces. Here we first discuss a model of such deformation processes in volcanic regions with complex but mild topography. Then, we develop a simplified dike propagation model that we compare to a more sophisticated one. Next, we combine our models and simulate magma pathways in artificially‐generated scenarios.
    Description: Key Points: We present numerical models of crustal stress state in the presence of caldera structures. We develop a fast dike propagation model and validate it on a previous numerical model. We combine our stress and dike models to simulate magma pathways at synthetic calderas.
    Description: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
    Description: http://persson.berkeley.edu/distmesh/
    Description: https://doi.org/10.5281/zenodo.3694164
    Description: https://doi.org/10.5281/zenodo.4726796
    Description: https://doi.org/10.5281/zenodo.4727208
    Description: https://doi.org/10.5880/GFZ.2.1.2023.001
    Keywords: ddc:550.278 ; dike propagation ; magma pathways ; stress modeling ; pre‐eruptive scenarios ; calderas
    Language: English
    Type: doc-type:article
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  • 5
    Publication Date: 2021-10-27
    Description: We describe the Dark Energy Survey (DES) Deep Fields, a set of images and associated multi-wavelength catalogue (ugrizJHKs) built from Dark Energy Camera (DECam) and Visible and Infrared Survey Telescope for Astronomy (VISTA) data. The DES Deep Fields comprise 11 fields (10 DES supernova fields plus COSMOS), with a total area of ∼30 square degrees in ugriz bands and reaching a maximum i-band depth of 26.75 (AB, 10σ, 2″). We present a catalogue for the DES 3-year cosmology analysis of those four fields with full 8-band coverage, totalling 5.88 sq. deg. after masking. Numbering 2.8million objects (1.6million post masking), our catalogue is drawn from images coadded to consistent depths of r = 25.7, i = 25, z = 24.3 mag. We use a new model-fitting code, built upon established methods, to deblend sources and ensure consistent colours across the u-band to Ks-band wavelength range. We further detail the tight control we maintain over the point-spread function modelling required for the model fitting, astrometry and consistency of photometry between the four fields. The catalogue allows us to perform a careful star-galaxy separation and produces excellent photometric redshift performance (NMAD = 0.023 at i 〈 23). The Deep-Fields catalogue will be made available as part of the cosmology data products release, following the completion of the DES 3-year weak lensing and galaxy clustering cosmology work.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 6
    Publication Date: 2023-11-24
    Description: In contrast to large river plumes, Coriolis effects are weak, and inertia is quickly depleted so that the fate and structure of small‐scale plumes are more sensitive to tide and wind. Advected alongshore by reversing tidal currents in absence of wind forcing, small buoyant plumes are persistently deflected downwind in presence of alongshore winds and exhibit little tidal variability. The effect of different upwelling/downwelling winds on buoyant outflows ∼10 m3 s−1 is explored. With increasing wind, tidal variability decreases, as does asymmetry in plume characteristics—for strong winds upwelling/downwelling plume structure is similar as the plume is retained closer to the shore. Wind forcing is exerted directly by wind stress on the surface of the plume and indirectly by wind‐driven currents that deflect the upwind boundary of the plume. While inertia and buoyancy dominate the inner plume, and wind dominates the outer plume, the mid‐plume responds to an interaction of wind and buoyancy forcing that can be indexed by a Plume Wedderburn Number Wpl (wind stress vs. density gradients): for weaker winds (Wpl 〈 1) surface stress enhances stratification through straining, lengthening the reach of low‐salinity waters, whereas for stronger winds (Wpl 〉 1) surface stress mixes the plume vertically, shortening the reach of low‐salinity waters. However, dilute plume waters extend furthest in strong winds, passively advected several kilometers downwind. Shoreline exposure to outflow transitions from a quasi‐symmetrical tide‐averaged zone of impact under zero‐wind to a heavily skewed zone with persistent weak wind and a one‐sided zone for strong wind.
    Description: Plain Language Summary: Compared to large river plumes, outflow from small rivers and mountainous streams is more sensitive to tides and winds because of the weak Coriolis effect and quickly reduced inertia. Alongshore (upwelling/downwelling) winds carry these small plumes in their direction. We use a numerical model to study the effect of these upwelling/downwelling winds on plumes spreading from small rivers with discharge rates of 10 m3 s−1 or less. Increasing wind reduces tidal fluctuations in plume patterns such that with strong winds the plume spreads similarly for upwelling and downwelling winds as it remains close to the shore. Wind affects the plume surface directly and the upwind‐plume boundary indirectly via wind‐driven currents. Inertia and buoyancy control the inner plume while wind and buoyancy control the mid‐plume and wind controls the outer plume. Weaker winds increase the plume length and layering by horizontally tilting the density gradients. Stronger winds shorten the plume by vertically mixing it. However, dilute plume waters extend furthest in strong winds, passively advected several kilometers downwind.
    Description: Key Points: Plume bends downwind, with upstream boundary deflected by ambient current and downstream boundary deflected by surface wind stress. Asymmetry in plume shape between weak upwelling versus downwelling winds vanishes with strong winds that retain the plume nearshore where Ekman transport negligible. Inertia & buoyancy control the near‐field; wind forcing & buoyancy control the mid‐field; wind mixing & passive advection control the far‐field.
    Description: National Science Foundation http://dx.doi.org/10.13039/100000001
    Description: Leibniz Institute für Ostseeforschung Warnemünde
    Description: http://doi.io-warnemuende.de/10.12754/data-2022-0009
    Keywords: ddc:551.46 ; small‐scale river plumes ; creek plumes ; upwelling downwelling winds ; high resolution river plume dynamics ; idealized numerical model
    Language: English
    Type: doc-type:article
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  • 7
    Publication Date: 2023-07-21
    Description: 2021 inter-sessional Science Board meeting - Note from the science Board Chair. FUTURE SCC's 7th inter-sessional meeting highlights. Sustainability of Marine Ecosystems Through Knowledge Networks (SMARTNET) Endorsed as a UN Decade of Ocean Science Program. SMARTNET featured in ECO magazine. Early Career Ocean Professionals: Evolving Contributions to PICES & the UN Ocean Decade. Pacific Ecology and Evolution Conference. The (Virtual) International Symposium on Plastics in the Arctic and Sub-Arctic Regions. Hal Batchelder's legacy - in PICES words. The western North Pacific during the 2020/2021 cold season. Behring Sea: Current status and recent trends. The Northeast Pacific: Update on Marine Heat Wave Status. PICES by the numbers - finding balance. Your PICES science images Feature: SEAturtle Special Project. About PICES Press.
    Description: Published
    Description: Non Refereed
    Repository Name: AquaDocs
    Type: Book/Monograph/Conference Proceedings
    Format: 38
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  • 8
    Publication Date: 2023-03-01
    Description: The European Union (EU) has firmly positioned itself as a global leader in promoting and implementing nature-based solutions (NBS). The recently released EU Biodiversity Strategy for 2030, Strategy on Adaptation to Climate Change, and Forest Strategy - all representing key pillars of the ambitious European Green Deal (EGD) - rely on NBS to both preserve and restore ecosystem integrity and increase climate resilience. Although research and policy in Europe have advanced the conceptualization and operationalization of NBS, a much wider adoption is needed to reach the ambitious goals of the EGD and fulfil its vision of transforming into a sustainable, climate-neutral, climate resilient, fair, and prosperous EU by 2050. In this paper, we review recent EU-supported research, policy, and practices to identify critical dimensions that still need to be addressed for greater uptake of NBS. While recognising the multiple societal challenges NBS can target, we build on the key messages from the ‘5th European Climate Change Adaptation conference ECCA 2021′ and focus our analysis on NBS for climate change adaptation and disaster risk reduction. We screen a wide range of NBS cases across the EU and identify-three core challenges to implementation: the lack of a comprehensive evidence base on the effectiveness of NBS to address targeted challenges; the need for a greater involvement of the private sector in financing NBS; and opportunities for enhancing stakeholder engagement in the successful design and implementation of NBS. We take these challenges as the starting point for a broader reflection and critical discussion on the role of i) knowledge, i) finance, including investments in NBS and divestments from nature-negative projects, and iii) governance and policy frameworks to enable the uptake of NBS. We conclude by identifying options for the EU to foster the uptake of NBS in research, policy and practice.
    Description: Published
    Description: 100450
    Description: 4A. Oceanografia e clima
    Description: JCR Journal
    Keywords: Nature-based solutions ; European Union ; European Green Deal ; Climate change adaptation ; Disaster risk reduction ; 05.08. Risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2024-03-14
    Description: The Antarctic Ice Sheet represents the largest source of uncertainty in future sea level rise projections, with a contribution to sea level by 2100 ranging from −5 to 43 cm of sea level equivalent under high carbon emission scenarios estimated by the recent Ice Sheet Model Intercomparison for CMIP6 (ISMIP6). ISMIP6 highlighted the different behaviors of the East and West Antarctic ice sheets, as well as the possible role of increased surface mass balance in offsetting the dynamic ice loss in response to changing oceanic conditions in ice shelf cavities. However, the detailed contribution of individual glaciers, as well as the partitioning of uncertainty associated with this ensemble, have not yet been investigated. Here, we analyze the ISMIP6 results for high carbon emission scenarios, focusing on key glaciers around the Antarctic Ice Sheet, and we quantify their projected dynamic mass loss, defined here as mass loss through increased ice discharge into the ocean in response to changing oceanic conditions. We highlight glaciers contributing the most to sea level rise, as well as their vulnerability to changes in oceanic conditions. We then investigate the different sources of uncertainty and their relative role in projections, for the entire continent and for key individual glaciers. We show that, in addition to Thwaites and Pine Island glaciers in West Antarctica, Totten and Moscow University glaciers in East Antarctica present comparable future dynamic mass loss and high sensitivity to ice shelf basal melt. The overall uncertainty in additional dynamic mass loss in response to changing oceanic conditions, compared to a scenario with constant oceanic conditions, is dominated by the choice of ice sheet model, accounting for 52 % of the total uncertainty of the Antarctic dynamic mass loss in 2100. Its relative role for the most dynamic glaciers varies between 14 % for MacAyeal and Whillans ice streams and 56 % for Pine Island Glacier at the end of the century. The uncertainty associated with the choice of climate model increases over time and reaches 13 % of the uncertainty by 2100 for the Antarctic Ice Sheet but varies between 4 % for Thwaites Glacier and 53 % for Whillans Ice Stream. The uncertainty associated with the ice–climate interaction, which captures different treatments of oceanic forcings such as the choice of melt parameterization, its calibration, and simulated ice shelf geometries, accounts for 22 % of the uncertainty at the ice sheet scale but reaches 36 % and 39 % for Institute Ice Stream and Thwaites Glacier, respectively, by 2100. Overall, this study helps inform future research by highlighting the sectors of the ice sheet most vulnerable to oceanic warming over the 21st century and by quantifying the main sources of uncertainty.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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  • 10
    Publication Date: 2023-10-05
    Description: This book examines the Army's role in the war on terrorism; the Army's homeland security needs; the implications of increased emphasis on Asia; the Army's role in coalition operations; the unfinished business of jointness-the lessons learned from operations and how to prepare for the future; the Army's deployability, logistical, and personnel challenges; and whether the Army can afford its Transformation. These examinations are bracketed by an introduction, a description of the Army's place in the new national security strategy, and a summary of the authors' conclusions.
    Keywords: Political Science ; Management & Organizational Behavior ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques::KJMV Management of specific areas::KJMV2 Personnel & human resources management ; bic Book Industry Communication::J Society & social sciences::JW Warfare & defence
    Language: English
    Format: image/jpeg
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