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  • 2020-2024  (4)
  • 1985-1989  (26)
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  • 1
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    Le savant, le langage et le pouvoir : Lecture du Livre du plaisir partagé en amitié (Kitāb al-imtāʿ wa-l-muʾānasa) d’Abū Ḥayyān al-Tawḥīdī (2021)
    ENS Éditions
    Details
    Publication Date: 2024-04-05
    Description: Les relations entre les intellectuels et le pouvoir constituent un enjeu majeur des sociétés arabes contemporaines. Cet ouvrage, qui fait remonter cette problématique au cœur de la société savante de l’époque arabe médiévale, actualise un débat des plus modernes en s’efforçant de montrer comment le progrès de la connaissance, le choix des mots, la transgression sont autant d’outils à disposition de l’homme de lettres à la cour pour défier l’autorité par ses seuls écrits, et partant, pour appeler à la réformer. Réputé ardu en raison de sa prose difficile d’accès, le Livre du plaisir partagé en amitié de Tawhīdī est souvent assimilé à une galerie de récits plaisants susceptibles d’édifier le public, à l’image de la vocation première des belles lettres arabes de l’époque médiévale. Cette étude vise en outre à montrer que le message de l’œuvre dépasse cette perspective pour plonger le lecteur au cœur d’une démarche qui tend à faire du savant le concurrent direct du gouvernant.
    Keywords: B1-5802 ; JA1-92 ; literary man ; political philosophy ; prose writer ; language ; scholar ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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    E-BOOK
  • 2
    Electronic Resource
    Electronic Resource
    Regulation of Rat Liver Acute Phase Genes by Interleukin-6 and Production of Hepatocyte Stimulating Factors by Rat Hepatoma Cells (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 557 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb24024.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Colonisation d'une population d'Oscillatoria rubescens (Cyanophyceae) par une bacterie epiphyte (1989)
    Springer
    Aquatic sciences 51 (1989), S. 59-66 
    Details
    ISSN: 1420-9055
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The presence of unknown bacteria upon filaments of the CyanophyteOscillatoria rubescens was observed in the Lake Leman (Lake of Geneva) during Autumn 1985. Conditions of this colonization and the morphology of the association are described. These bacteria probably belong to theCaulobacter group. To explain this colonization we suggest that bacteria respond chemotactically to Cyanophyte exudates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877781
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  • 4
    Electronic Resource
    Electronic Resource
    Water quality in rivers of western Switzerland: Application of an adaptable index based on benthic invertebrates (1989)
    Springer
    Aquatic sciences 51 (1989), S. 224-234 
    Details
    ISSN: 1420-9055
    Keywords: Benthos ; index ; invertebrates ; rivers ; Switzerland ; water quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Water quality was estimated from 205 samples of benthic invertebrates collected between 1982 and 1986 in 51 rivers of western Switzerland (canton of Vaud). Each sample consisted of the combined list of taxa resulting from one spring sample pooled with one summer sample. Water quality was indicated by total number of taxa and number of taxa intolerant of pollution: i. e. Heptageniidae, Plecoptera, and Trichoptera with a case. Six classes of values were delimited for each of these two variables by cluster analysis. Values from zero to five were attributed to each class. The index of water quality was computed by adding these two values in each sample. According to this index, good water quality was indicated by 42% of samples. This index can be adapted to other rivers because its components are easily modified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877744
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  • 5
    Electronic Resource
    Electronic Resource
    Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants (1986)
    [s.l.] : Nature Publishing Group
    Nature 323 (1986), S. 340-343 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Comparative phenotype of ras transformants, a, Aggregations of ras-Gly 12(G) and ras-Thr 12(T) transformants, photographed at indicated times (h). 11, tight aggregation; 14, slug formation; 16-25, culmination for KAx-3 cells, b, Organized streams of cells, wt, Wild type. Methods. The ras-Gly ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/323340a0
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  • 6
    Electronic Resource
    Electronic Resource
    Endocytosis and inositol hexakisphosphate levels inras transformants ofDictyostelium discoideum amoebae (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 365-367 
    Details
    ISSN: 1420-9071
    Keywords: Fluid-phase pinocytosis ; enzyme secretion ; inositol hexakisphosphate ; ras genes ; Dictyostelium discoideum ; amoebae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fluid-phase pinocytosis kinetics and lysosomal enzyme secretion parameters were measured inDictyostelium discoideum amoebae constructed from strain AX3 by transformation with a multicopy plasmid carrying either a normalras gene (ras-Gly12), a mutatedras gene (ras-Thr12) or by the vector carrying the geneticin resistance gene only (pDNEO2). It was found that the pinocytosis rate and extent as well as the lysosomal enzyme secretion were slightly different in the three strains. These changes, however, were related to minor modifications of the cellular volumes. The overall concentration of inositol hexakisphosphate was similar in the three strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957480
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  • 7
    Electronic Resource
    Electronic Resource
    Les Stephanodiscus (Diatomées) du Lac Léman: Description d'une nouvelle espèce, Stephanodiscus irregularis; mise au point taxonomique et distributions saisonnières (1987)
    Springer
    Hydrobiologia 148 (1987), S. 79-86 
    Details
    ISSN: 1573-5117
    Keywords: Lake Geneva ; Diatoms ; Stephanodiscus ; morphology ; taxonomy ; ecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Stephanodiscus (Diatoms) of Lake Geneva: Taxonomic changes, description of a new species (Stephanodiscus irregularis) and seasonal distributions. Both light and electron microscopy have been used to describe the species of Stephanodiscus collected in the plankton of Lake Geneva (Lac Léman, France-Switzerland) during the last few years. Eight taxa have been identified: S. irregularis nov. sp.; S. alpinus Hustedt = S. astraea var. minutula (Kütz.) Grunow; S. binderianus (Kütz.) Krieger var. binderianus; S. binderianus var. oestrupii (A. Cl.) A. Cl.; S. minutula (Kütz.) Round; S. parvus Stoermer & Hakansson = S. subtilis Van Goor var. subtilis; S. neoastraea Hakansson & Hickel; Cyclostephanos dubius (Fricke) Round = S. dubius (Fricke) Hustedt. Seasonal and interannual variations of some of these species are also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00018168
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  • 8
    Electronic Resource
    Electronic Resource
    On the dose dependency of Cyclosporin a absorption and disposition in healthy volunteers (1988)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 16 (1988), S. 331-353 
    Details
    ISSN: 1573-8744
    Keywords: Cyclosporin A ; pharmacokinetics ; dose dependency ; oral absorption ; disposition ; healthy subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of Cyclosporin A (CyA, SandimmuneR) was studied in 12 healthy male volunteers after oral dosing of 350 mg, 700 mg, and 1400 mg as a drinking solution. Blood samples were collected over 96 hr and analyzed by high pressure liquid chromatography. Concentration data were evaluated with model-independent and model-based linear pharmacokinetic concepts. Individual CyA concentration-time profiles in whole blood were well described by a two-compartment open model with zero-order absorption for all three doses. Comparison of pharmacokinetic parameters across doses indicates that both absorption and disposition are dose-dependent. Nonlinear disposition is suggested by the significant increase of the terminal half-life from 8.9±4.9hr to 11.9±4.9hr (mean±SD) after a 350 mg and a 1400 mg dose, respectively. Changes in the metabolic activity of the liver with concentration might be responsible for this phenomenon. In addition, the modeling approach indicated that bioavailability decreases with increasing dose. Moreover, the dependence of the rate of CyA absorption (zero-order rate constant) versus dose was well described by a hyperbola. The limited solubility of the drug in the gastrointestinal tract might be responsible for this behavior. The lag time (0.2–0.8 hr) was independent of dose. This value is similar to the time of gastric emptying in fasting volunteers. The duration of absorption for 11 of 12 subjects was in the range 2.5–3.5 hr over all doses and agrees well with the small intestine transit time. Some subjects showed a marked secondary peak at one or two doses, which could be adequately fitted by a model with two successive zero-order inputs. This double-peak behavior was ascribed to the influence of the food on gastric emptying. Dose dependency of disposition and absorption counterbalance each other in the usual dose range. This leads to an almost proportional increase of area under the blood CyA concentration-time profile with increasing dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01062550
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  • 9
    Electronic Resource
    Electronic Resource
    In Vivo Model for Ciclosporin Intestinal Absorption in Lipid Vehicles (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 677-679 
    Details
    ISSN: 1573-904X
    Keywords: Ciclosporin ; intestinal absorption ; lipid vehicle ; in vivo model ; lipid digestion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The influence of lipid vehicles on the intestinal absorption of Ciclosporin was studied in vivo. The model takes into account the effect of the intestinal lipid digestion on the absorption after intraduodenal administration of [3H]Ciclosporin in olive oil or middle-chain triglyceride (MCT) to the bile duct-cannulated rat. Digested vehicles significantly promoted the absorption compared to nondigested vehicles. In the nondigested state, olive oil was a significantly better vehicle than MCT, whereas the difference between both lipids was only a trend in the digested state. Further studies with variants of this in vivo model should determine the influence of abnormalities of fat digestion and absorption on the pharmacokinetics and pharmacodynamics of a drug with a low therapeutical index.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015939307478
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  • 10
    Electronic Resource
    Electronic Resource
    In Vitro Model for Ciclosporin Intestinal Absorption in Lipid Vehicles (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 673-676 
    Details
    ISSN: 1573-904X
    Keywords: Ciclosporin ; intestinal absorption ; lipid vehicle ; in vitro model ; lipid digestion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The influence of lipid vehicles on the intestinal absorption of Ciclosporin was studied in vitro. The effect of the intestinal lipid digestion was considered on the partition of the drug from olive oil or middle-chain triglyceride (MCT) into phases of simulated intestinal content. The phases obtained after ultracentrifugation were analyzed for their Ciclosporin content and characterized for their lipid classes. For both lipid vehicles the presence of lipolysis products did not promote the partition of the drug into the aqueous phase. The absorption in vivo was not related to the drug amount in the aqueous phase and in the oil phase. Therefore, phase quantification in vitro cannot simulate the dynamics of in vivo absorption events following application of a poorly water-soluble drug in a lipid vehicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015987223407
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