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  • 2020-2024  (125)
  • 2000-2004  (2,602)
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  • 1
    Online Resource
    Online Resource
    Pandemic Cities : The COVID-19 Crisis and Australian Urban Regions (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Sustainability. ; Urban policy. ; Public health. ; Urban economics. ; Human geography. ; Sustainability. ; Urban Policy. ; Public Health. ; Urban Economics. ; Human Geography.
    Description / Table of Contents: COVID-19 and Australian cities: when the pandemic came to town -- Population challenges and change in pandemic cities -- COVID-19 and the social structure of cities: The forgotten vulnerable -- The great job reshuffle: How COVID-19 changed urban labour markets -- Housing and the pandemic -- Moving around the COVID city -- Planning the COVID city -- The future of COVID cities.
    Abstract: This book highlights the impact of the COVID-19 pandemic on cities. The COVID-19 pandemic and the associated economic and social impacts have been felt around the world. In large cities and other urban areas, the pandemic has highlighted a number of issues from pressures on urban labour and housing markets, shifts in demographic processes including migration and mobility, changes in urban travel patterns and pressures on contemporary planning and governance processes. Despite Australia’s relatively mild COVID exposure, Australian cities and large urban areas have not been immune to these issues. The economic shutdown of the country in the early stages of the pandemic, the sporadic border closures between states, the effective closure of international borders and the imposition of widespread public health orders that have required significant behavioural change across the population have all changed our cities in some and the way we live and work in them in some way. Some of the challenges have reflected long-standing problems including intrenched inequality in labour markets and housing markets, others such as the impact on commuting patterns and patterns of migration have emerged largely during the pandemic. This book, co-authored by experts in their field, outlines some of the major issues facing Australian cities and urban areas as a result of the pandemic and sets a course for future of the cities we live in.
    Type of Medium: Online Resource
    Pages: XII, 123 p. 49 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811958847
    Series Statement: Cities Research Series,
    URL: https://doi.org/10.1007/978-981-19-5884-7
    DOI: 10.1007/978-981-19-5884-7
    DDC: 304.2
    Language: English
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  • 2
    Online Resource
    Online Resource
    Forests as Complex Social and Ecological Systems : A Festschrift for Chadwick D. Oliver (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Applied ecology. ; Environmental management. ; Forestry. ; Environmental sciences Social aspects. ; System theory. ; Applied Ecology. ; Environmental Management. ; Forestry. ; Environmental Social Sciences. ; Complex Systems.
    Description / Table of Contents: Introduction -- 1. Chad Oliver and forests as complex systems; Melih Boydak -- Section I. Complex Forest Stand Dynamics -- 2. Principles of stand reconstruction to illuminate stand dynamics of complex forests in Alaska; Bob Deal -- 3: Forest stand dynamics principles used to guide the management of uneven-aged forest in the Missouri Ozarks; Dave Larsen -- 4: Forest stand dynamics and the curious case of the critically endangered Leadbeater’s Possum; Patrick Baker -- 5: Modelling and mapping complex stand structures with airborne LiDAR; John Kershaw -- 6. How might the concepts of traditional stand dynamics be used for more complex stands; Bruce Larson -- Section II. Forests as Complex Ecological Systems -- 7. Integrating effects of climate on temperate montane forests; Pil Sun Park -- 8. Carbon++: integrating non-CO2 forcers in our understanding of forests and climate; Kris Covey -- 9. Understanding post-wildfire fuel dynamics in dry forests of the Pacific Northwest; Morris Johnson -- 10. Understanding forestry through pictures: A journey of graphics, pictures, and visualisations; Jim McCarter -- 11. The inertia of forested landscapes and applications to management; Jeremy Wilson -- Section III. Forests as Complex Social Systems -- 12. Tiger in the woods, elephant in the room; Xuemei Han -- 13. Forests as complex systems: Implications from the perspective of sustainable development; Glenn Galloway -- 14. Securing forest tenure for rural development; Gerardo Segura -- 15. Understanding the dynamics between forests and livelihoods: A case of Central Indian landscapes; Alark Saxena -- 16. Closing comments; Chad Oliver. .
    Abstract: Professor Chadwick Dearing Oliver has made major intellectual contributions to forest science and natural resources management. Over the course of his career he has actively sought to bring research and practice together through synthesis, outreach, and capacity-building. A common thread throughout his career has been complexity and how we as a society understand and manage complex systems. His work on forest stand dynamics, landscape management, and sustainability have all focused on the emergent properties of complex ecological and/or social systems. This volume celebrates a remarkable career through a diverse group of former students and colleagues who work on a wide range of subject areas related to the management of complex natural resource systems. Over the past decade there has been considerable discussion about forests as complex adaptive systems. Advances in remote sensing, social methods, and data collection and processing have enabled more detailed characterisations of complex natural systems across spatial and temporal scales than ever before. Making sense of these data, however, requires conceptual frameworks that are robust to the complexity of the systems and their inherent dynamics, particularly in the context of global change. This volume presents a collection of cutting-edge research on natural ecosystems and their dynamics through the lens of complex adaptive systems. Each chapter offers new insights into how these systems can be made more resilient to ensure that they provide a diversity of ecological and social values well into the future. Together they provide a robust way of thinking about the many challenges that natural ecosystems face and how we as society may best address them.
    Type of Medium: Online Resource
    Pages: XVIII, 334 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030885557
    Series Statement: Managing Forest Ecosystems, 41
    URL: https://doi.org/10.1007/978-3-030-88555-7
    DOI: 10.1007/978-3-030-88555-7
    DDC: 333.9516
    Language: English
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  • 3
    Online Resource
    Online Resource
    Agromining: Farming for Metals : Extracting Unconventional Resources Using Plants (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Environmental engineering. ; Biotechnology. ; Bioremediation. ; Pollution. ; Energy policy. ; Energy and state. ; Environmental Engineering/Biotechnology. ; Pollution. ; Energy Policy, Economics and Management.
    Description / Table of Contents: 1 The Long Road to Developing Agromining/Phytomining -- 2 Agronomy of ‘Metal Crops’ Used in Agromining -- 3 Processing of Bio-ore to Products -- 4 Processing of Bio-ore to Products: REEs, and other elements -- 5 Life Cycle Assessment and Ecosystem Services of Agromining -- 6 Global Distribution and Ecology of Hyperaccumulator Plants -- 7 Physiology and Molecular Biology of Trace Element Hyperaccumulation -- 9 Tools for the Discovery of Hyperaccumulator Plant Species and Understanding Their Ecophysiology -- 10 Genesis and Behaviour of Ultramafic Soils and Consequences for Nickel Biogeochemistry -- 11 The Role of the Rhizosphere and Microbes Associated with Hyperaccumulator Plants in Metal Accumulation -- 12 Incorporating Hyperaccumulator Plants into Mine Rehabilitation in the Asia-Pacific Region -- 13 Agromining of High-Value Elements and Contaminants from Minerals Wastes -- 14 Agromining from Various Industrial Wastes -- 15 Phytoextraction of Cadmium: Feasibility in Field Applications and Potential Use of Harvested Biomass -- 16 Metal recovery with agromining from former mine and industrial sites under restoration -- 17 Element Case Studies: Nickel (temperate/Mediterranean regions).
    Abstract: This second and expanded edition of the first book on agromining (phytomining) presents a comprehensive overview of the metal farming & recovery of the agromining production chain. Agromining is an emerging technology that aims to transform the extraction of sources of target elements not accessible by traditional mining and processing techniques. Agromining, which is based on sustainable development, uses hyperaccumulator plants as 'metal crops' farmed on sub-economic soils or minerals wastes to obtain valuable target elements. This volume is edited and authored by the pioneers in the rapidly expanding field of agromining and presents the latest insights and developments in the field. This book provides in-depth information on the global distribution and ecology of hyperaccumulator plants, their biogeochemical pathways, the influence of rhizosphere microbes, the physiology and molecular biology of hyperaccumulation, as well as aspects of propagation and conservation of these unusual plants. It describes the agronomy of metal crops and opportunities for incorporating agromining into rehabilitation and mine closure, including test cases for agromining of nickel, cobalt, manganese, arsenic, selenium, cadmium, zinc, thallium, rare earth elements and platinum group elements. Since the first edition was published, there have successful nickel agromining field trials in the tropics (in Malaysia and Guatemala), and these are presented in a dedicated case study chapter. Other new chapters focus on the processing of bio-ore for elements other than nickel, such as rare earth elements and cadmium, and on agromining from industrial wastes such as tailings, and industrial by-products and sites. Furthermore, the book features two new chapters that provide a comprehensive assessment of accumulation a very wide range elements from the Periodic Table in various plant species around the globe, and a chapter on practical methods for discovery of hyperaccumulator plant species in the field and in the herbarium. This book is of interest to environmental professionals in the minerals industry, government regulators, and academics.
    Type of Medium: Online Resource
    Pages: IX, 489 p. 119 illus., 108 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030589042
    Series Statement: Mineral Resource Reviews,
    URL: https://doi.org/10.1007/978-3-030-58904-2
    DOI: 10.1007/978-3-030-58904-2
    DDC: 628
    Language: English
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  • 4
    Series available for loan
    Series available for loan
    Volcanic rifted margins (2002)
    Boulder, Colo. : The Geological Society of America
    Associated volumes
    Details Availability
    Call number: S 90.0095(362)
    In: Special paper / The Geological Society of America, 362
    Type of Medium: Series available for loan
    Pages: VI, 230 Seiten , Illustrationen, graphische Darstellungen, Karten
    ISBN: 0-8137-2362-0
    Series Statement: Special paper / The Geological Society of America 362
    URL: http://digitale-objekte.hbz-nrw.de/storage2/2018/06/15/file_365/7918592.pdf
    Language: English
    Note: Preface 1. Characteristics of volcanic rifted margins Martin A. Menzies, Simon L. Klemperer, Cynthia J. Ebinger, and Joel Baker 2. Crust and upper mantle structure in East Africa: Implications for the origin of Cenozoic rifting and volcanism and the formation of magmatic rifted margins Andrew A. Nyblade 3. Development of the Lebombo rifted volcanic margin of southeast Africa M.K. Watkeys 4. Extension and uplift of the northern Rio Grande Rift: Evidence from ⁴⁰Ar/³⁹Ar geochronology from the Sangre de Cristo Mountains, south-central Colorado and northern New Mexico Daniel P. Miggins, Ren A. Thompson, Charles L. Pillmore, Lawrence W. Snee, and Charles R. Stern 5. Lithospheric mantle beneath Arabia: A Pan-African protolith modified by the Afar and older plumes, rather than a source for continental flood volcanism? Joel Baker, Gilles Chazot, Martin A. Menzies, and Matthew Thirlwall 6. Petrogenesis of the Late Cretaceous tholeiitic magmatism in the passive margins of northeastern Madagascar Leone Melluso, Vincenzo Morra, Pietro Brotzu, Massimo D'Antonio, and Lucia Bennio 7. Silicic volcanism: An undervalued component of large igneous provinces and volcanic rifted margins Scott E. Bryan, Teal R. Riley, Dougal A. Jerram, Christopher J. Stephens, and Philip T Leat 8. Volcanology and fades architecture of flood basalts Dougal A. Jerram 9. East Greenland coast-parallel dike swarm and its role in continental breakup Martin Bromann Klausen and Hans Christian Larsen 10. Crustal architecture of South Atlantic volcanic margins W.U. Mohriak, B.R. Rosendahl, J.P. Turner, and S.C. Valente 11. Volcanic passive margin of Namibia: A potential fields perspective B. Corner, J. Cartwright, and R. Swart 12. Petrophysical modeling of high seismic velocity crust at the Namibian volcanic margin R.B. Trumbull, S.V. Sobolev, and K. Bauer
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  • 5
    Monograph available for loan
    Monograph available for loan
    Seismic hazard and risk analysis (2021)
    Cambridge, United Kingdom : Cambridge University Press
    Details Availability
    Call number: M 23.95135 ; 8/M 23.95382
    Description / Table of Contents: "An overview of the essential principles of seismic hazard and risk analysis, including advanced topics, worked examples and problem sets. (20) An overview of the essential principles and procedures of seismic hazard and risk analysis, of interest to earth scientists and engineers. Coverage includes state-of-the-art procedures, advanced topics, and future research directions. Each chapter includes worked examples and problem sets, with solutions and computer codes provided online. (46/341) Probabilistic Seismic Hazard and Risk Analyses underpin the loadings prescribed by engineering design codes, the decisions by asset owners to retrofit structures, the pricing of insurance policies, and many other activities. This is a comprehensive overview of the principles and procedures behind seismic hazard and risk analysis. It enables readers to understand best practises and future research directions. Early chapters cover the essential elements and concepts of seismic hazard and risk analysis, while later chapters shift focus to more advanced topics. Each chapter includes worked examples and problem sets for which full solutions are provided online. Appendices provide relevant background in probability and statistics. Computer codes are also available online to help replicate specific calculations and demonstrate the implementation of various methods. This is a valuable reference for upper level students and practitioners in civil engineering, and earth scientists interested in engineering seismology. (143)"--
    Type of Medium: Monograph available for loan
    Pages: xii, 581 Seiten , Illustrationen , 27 cm
    ISBN: 9781108425056 , 978-1-108-42505-6
    URL: https://www.gbv.de/dms/tib-ub-hannover/1767772416.pdf
    DOI: 10.1017/9781108425056
    Language: English
    Note: Contents Preface Introduction 1.1 Hazard and Risk Analysis 1.2 Uses of Hazard and Risk Infonnation 1.3 Detenninistic Analysis 1.4 Probabilistic Seismic Hazard Analysis 1.5 Probabilistic Risk Analysis 1.6 Benefits of Probabilistic Analysis I. 7 Uncertainties in Probabilistic Analysis 1.8 Validation Part I Hazard Inputs 2 Seismic Source Characterization 2.1 Introduction 2.2 Earth Structure and Plate Tectonics 2.3 Faults 2.4 Earthquake Processes 2.5 Earthquake Size 2.6 Definitions of Seismic Sources 2. 7 Source Characteristics 2.8 Conceptual Development of SSMs Exercises 3 Characterization of Earthquake Rates and Rupture Scenarios 3.1 Introduction 3.2 Approaches to Determining Rupture Rates 3.3 Constraints from Seismicity Data 3.4 Geological Constraints on Activity 3.5 Magnitude-Frequency Distributions 3.6 Rupture Scenarios and Computation of Rates 3.7 Generation of Rupture Scenarios 3.8 Time-Dependent Ruptw-e Rates Exercises 4 Empirical Ground-Motion Characterization 147 4.1 Introduction 147 4.2 Engineering Characterization of Ground Motion 149 4.3 Ground-Motion Databases 161 4.4 Mathematical Representation 166 4.5 General Trends in Empirical Data and Models 170 4.6 Prediction Using Empirical GMMs 179 4.7 Epistemic Uncertainty 186 4.8 Limitations of Empirical GMMs 192 Exercises 193 5 Physics-Based Ground-Motion Characterization 196 5.1 Introduction 196 5.2 Utility of Physics-Based Ground-Motion Simulation 198 5.3 Earthquake Source Representation 200 5.4 Seismic Wave Propagation 205 5.5 Methods for Physics-Based Ground-Motion Simulation 220 5.6 Prediction Using Physics-Based GMMs 233 Exercises Part II Hazard Calculations 247 6 PSHA Calculation 249 6.1 Introduction 249 6.2 The PSHA Calculation 250 6.3 Example Calculations 255 6.4 Hazard Curve Metrics 262 6.5 Sensitivity of Hazard Results to Inputs 266 6.6 Model Uncertainty 269 6.7 Logic Trees 272 6.8 PSHA with Epistemic Uncertainty 276 6.9 Monte Carlo PSHA 279 6.10 Discussion 280 Exercises 7 PSHA Products 286 7.1 Introduction 286 7.2 Disaggregation 287 7.3 Uniform Hazard Spectrum 301 7.4 Hazard Maps 306 7.5 Conditional Spectrum 307 7.6 VectorPSHA 312 7.7 Earthquake Sequences in PSHA 312 7.8 Implementation and Documentation of Hazard Studies 316 Exercises 8 Non-Ergodic Hazard Analysis 8.1 Introduction 8.2 Fundamental Concepts 8.3 Aleatory Variability versus Epistemic Uncertainty 8.4 When Can Non-Ergodic Approaches Be Applied? 8.5 Non-Ergodic Ground-Motion Models 8.6 Non-Ergodic Site Effects 8.7 Non-Ergodic Path Effects 8.8 Non-Ergodic Source Effects 8.9 Non-Ergodic Components in Seismic-Source Models Exercises Part Ill Risk 9 Seismic Risk 9.1 Introduction 9.2 Fragility and Vulnerability Functions 9.3 Calibrating Fragility and Vulnerability Functions 9.4 Risk Metrics 9.5 PEER Framework 9.6 Epistemic Uncertainty 9.7 Risk-Targeted Ground-Motion Intensity Exercises 10 Ground-Motion Selection I 0.1 Introduction I 0.2 Principles of Hazard-Consistent Ground-Motion Selection 10.3 Target Intensity Measure Distributions I 0.4 Selection Algorithms 10.5 Assessing Accuracy and Precision of Seismic Responses 10.6 Application-Specific Decisions 10.7 Design Code and Guideline Requirements 10.8 Documentation Exercises 11 Spatially Distributed Systems 11.1 Introduction 11.2 Parameterization Using Empirical Ground-Motion Models 11.3 Parameterization Using Physics-Based Simulations 11.4 Numerical Implementation 11.5 Coherency 11.6 Risk Exercises 12 Validation 12. l Introduction 12.2 Verification and Validation 12.3 Validation from Limited Observations 12.4 Direct Validation of Seismic Hazard Curves 12.5 Validation of Model Components 12.6 Do Failures of Past Calculations [nvalidate the PSHA Methodology? 12.7 Seismic Hazard and Risk Analysis for Decision-Making Exercises Appendix A Basics of Probability A. l Random Events A.2 Conditional Probability A.3 Random Variables A.4 Expectations and Moments A.5 Common Probability Distributions A.6 Random Number Generation Appendix B Basics of Statistics for Model Calibration 1 B.3 Statistical Estimation of m1,,x my,y B.5 Maximum Likelihood Estimation of Seismicity Parameters Estimation ofIM ofSymbols 433 484 486 494 514 519 523 529 533 578 viii Contents 12 Validation 12. l Introduction 12.2 Verification and Validation 12.3 Validation from Limited Observations 12.4 Direct Validation of Seismic Hazard Curves 12.5 Validation of Model Components 12.6 Do Failures of Past Calculations [nvalidate the PSHA Methodology? 12.7 Seismic Hazard and Risk Analysis for Decision-Making Exercises Appendix A Basics of Probability A. l Random Events A.2 Conditional Probability A.3 Random Variables A.4 Expectations and Moments A.5 Common Probability Distributions A.6 Random Number Generation Appendix B Basics of Statistics for Model Calibration B. l Confidence Intervals for the Sample Mean and Standard Deviation B.2 Hypothesis Testing for Statistical Significance B.3 Statistical Estimation of mmax B.4 Bayesian Estimation of lnmax B.5 Maximum Likelihood Estimation of Seismicity Parameters B.6 Empirical GMM Calibration B.7 Estimation of JM Correlations from GMMs B.8 Fragility Function Fitting References List of Symbols and Abbreviations Notation Conventions Index
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  • 6
    Electronic Resource
    Electronic Resource
    Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin (2000)
    Springer
    JBIC 5 (2000), S. 692-698 
    Details
    ISSN: 1432-1327
    Keywords: Metal substitution Cerium binding Lactoferrin Crystal structure Transferrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Proteins of the transferrin family play a key role in iron homeostasis through their extremely strong binding of iron, as Fe3+. They are nevertheless able to bind a surprisingly wide variety of other metal ions. To investigate how metal ions of different size, charge and coordination characteristics are accommodated, we have determined the crystal structure of human lactoferrin (Lf) complexed with Ce4+. The structure, refined at 2.2 Å resolution (R=20.2%, R free=25.7%) shows that the two Ce4+ ions occupy essentially the same positions as do Fe3+, and that the overall protein structure is unchanged; the same closed structure is formed for Ce2Lf as for Fe2Lf. The larger metal ion is accommodated by small shifts in the protein ligands, made possible by the presence of water molecules adjacent to each binding site. The two Ce4+ sites are equally occupied, indicating that the known difference in the pH-dependent release of Ce4+ arises from a specific protonation event, possibly of the His ligand in one of the binding sites. Comparing the effects of binding Ce4+ with those for the binding of other metal ions, we conclude that the ability of transferrins to accommodate metal ions other than Fe3+ depends on an interplay of charge, size, coordination and geometrical preferences of the bound metal ion. However, it is the ability to accept the six-coordinate, approximately octahedral, site provided by the protein that is of greatest importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007750000157
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  • 7
    Electronic Resource
    Electronic Resource
    Expression, crystallization and preliminary characterization of methylmalonyl coenzyme A epimerase from Propionibacterium shermanii (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 706-708 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Methylmalonyl-CoA epimerase (MMCE) is an enzyme that interconverts the R and S epimers of methylmalonyl-CoA in the pathway that links propionyl-CoA with succinyl-CoA. This is used for both biosynthetic and degradative processes, including the breakdown of odd-numbered fatty acids and some amino acids. The enzyme has been expressed in Escherichia coli both as the native enzyme and as its selenomethionine (SeMet) derivative. Crystals of both forms have been obtained by vapour diffusion using monomethylether PEG 2000 as precipitant. The native MMCE crystals are orthorhombic, with unit-cell parameters a = 56.0, b = 114.0, c = 156.0 Å, and the SeMet-MMCE crystals are monoclinic, with unit-cell parameters a = 43.6, b = 78.6, c = 89.4 Å, β = 92.0°; both diffract to better than 2.8 Å resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444901002050
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  • 8
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray analysis of native and recombinant human bile-salt dependent lipase: strategies for improvement of diffraction quality (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 478-480 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Human bile-salt dependent lipase (BSDL), secreted into both the digestive tract and human milk, is integral to the effective absorption of dietary lipids. In attempts to obtain crystals suitable for high-resolution X-ray crystallographic studies, various forms of the enzyme have been crystallized, including native and desialidated human milk BSDL and both intact recombinant BSDL and a truncated form lacking the heavily glycosylated C-terminal repeat region. Trigonal crystals of native BSDL, with unit-cell parameters a = b = 90.0, c = 156.1 Å, were obtained using 15–20%(w/v) PEG 8000 as precipitant. These crystals diffract to 3.5 Å along the unique axis, but to only 5–7 Å in orthogonal directions. Crystals of recombinant truncated BSDL grown from 15–20%(w/v) PEG 6000 are orthorhombic, space group P212121, with unit-cell parameters a = 59.2, b = 90.0, c = 107.7 Å, and diffract to 2.6 Å resolution. These are suitable for structural analysis by X-ray crystallography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444900000986
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  • 9
    Electronic Resource
    Electronic Resource
    Subunit dissociation and reassociation leads to preferential crystallization of haemoglobin Bart's (γ4) from solutions of human embryonic haemoglobin Portland (ζ2γ2) at low pH (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 921-924 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A variety of human haemoglobins (Hbs) are produced at different stages of human development, including three embryonic Hbs, foetal Hb and adult Hb. All are heterotetramers. During crystallization experiments on human embryonic Hb Portland (ζ2γ2), it was discovered by crystallographic and biochemical analysis that the homotetramer Hb Bart's (γ4) preferentially crystallizes from ζ2γ2 solutions below pH 5. This results from dissociation of Hb Portland into γ2 dimers and ζ monomers and has interesting implications for subunit interactions and tetramer stability in Hbs. It also makes possible a full crystallographic analysis of Hb Bart's, which is of considerable medical significance because of its presence in the red blood cells of millions of people worldwide who suffer from α-thalassaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444901004516
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  • 10
    Electronic Resource
    Electronic Resource
    Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 411 (2001), S. 330-334 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The evolutionarily conserved Ras/mitogen-activated protein kinase (MAPK) cascade is an integral part of the processes of cell division, differentiation, movement and death. Signals received at the cell surface are relayed into the nucleus, where MAPK phosphorylates and thereby modulates the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35077122
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