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  • 2020-2024  (15)
  • 2005-2009  (222)
  • 2000-2004  (163)
  • 1955-1959  (22)
  • 1935-1939  (2)
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Keywords
Publisher
Language
Years
Year
  • 1
    Monograph available for loan
    Monograph available for loan
    Energy risk management : a primer for the utility industry (2006)
    Vienna, Va. : Public Utilities Reports
    Details Availability
    Call number: PIK P 113-07-0121
    Type of Medium: Monograph available for loan
    Pages: XXI,409 S. , graph. Darst.
    ISBN: 0910325189
    Note: Erscheinungsjahr in Vorlageform:c 2006
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    Monograph available for loan
    Monograph available for loan
    Ross ice shelf (2000)
    Schweden
    Details Availability
    Call number: AWI G5-02-0107
    Type of Medium: Monograph available for loan
    Pages: S. 139-432
    Series Statement: Geografiska Annaler Series A: Physical Geography 82A, 2000
    Branch Library: AWI Library
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  • 3
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    Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target (2021)
    InTechOpen | Drug Discovery | Drug Discovery
    Details
    Publication Date: 2024-04-01
    Description: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions.
    Keywords: pharmacology ; toxicology ; pharmacology ; toxicology ; Assay ; Enzyme ; Molar concentration ; Protein ; Thermal shift assay ; Trypanosoma brucei ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
    Format: image/jpeg
    Format: image/jpeg
    Format: image/jpeg
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    E-BOOK
  • 4
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    Correlation of Glacier ELA/Snowlines & Temperature Station data with ERA5 Temperature and Wind Speed, 1979 to 2017 (2022)
    PANGAEA
    Details
    Publication Date: 2024-04-20
    Description: This dataset contains the gridded correlation results from a study that sought to better understand the climatic footprint monitored by antipodal mid-latitude glacier populations. Understanding the links between glaciers and climate is critical for accurately interpreting contemporary cryosphere changes, and interrogating the causes of past glacier behavior. However, work is still needed to refine the extent to which they capture regional to hemisphere-scale atmospheric processes. A Pearson's correlation was performed between yearly summer seasonal data from the ERA5 gridded reconstructions of global temperature and wind changes on each available ERA5 pressure level and yearly glacier snowline/ELA elevations in the Southern Alps of New Zealand and in the European Alps. December-Febuary austral summer data was correlated with the Southern Alps records and June-August Northern Hemisphere summer data was correlated with the European Alps. The ERA5 input dataset was regridded onto a new monthly axis representing the true month lengths. Then the weighted seasonal average (December-February and June-August) was calculated. Individuals glaciers with Equilibrium Line Altitude (ELA; European Alps) and End of Summer Snowlines (EOSS; Southern Alps) were selected with respective records covering at least 80% of the 1979-2017/15 analysis period. The records from each glacier were then standardized and an EOF analysis was performed to obtain each location's First Principle Component for input into the Pearson's Correlation. A nearly identical set of analyses was performed using weather stations temperature data instead of glacier ELA/snowlines. The New Zealand station equivalent is from the National Institute of Water and Atmospheric Research (NIWA) New Zealand seven-station (NZ7S) series. The European Alps equivalent is from the HistAlp regional weather station syntheses. This companion analysis allows the glacier's ability to record the climate to be compared to that of meteorological instruments.
    Keywords: Alps; Binary Object; Binary Object (File Size); correlation; ERA5; European Alps; File content; glacier; New Zealand; Southern Hemisphere Westerly Winds; Westerlies
    Type: Dataset
    Format: text/tab-separated-values, 14 data points
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    DATA PANGAEA
  • 5
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    Micromagnetic coercivity distributions and interactions in chondrules with implications for paleointensities of the early solar system (2007)
    American Geophysical Union
    Details
    Publication Date: 2017-04-04
    Description: Chondrules in chondritic meteorites record the earliest stages of formation of the solar system, potentially providing information about the magnitude of early magnetic fields and early physical and chemical conditions. Using first-order reversal curves (FORCs), we map the coercivity distributions and interactions of 32 chondrules from the Allende, Karoonda, and Bjurbole meteorites. Distinctly different distributions and interactions exist for the three meteorites. The coercivity distributions are lognormal shaped, with Bjurbole distributions being bimodal or trimodal. The highest-coercivity mode in the Bjurbole chondrules is derived from tetrataenite, which interacts strongly with the lower-coercivity grains in a manner unlike that seen in terrestrial rocks. Such strong interactions have the potential to bias paleointensity estimates. Moreover, because a significant portion of the coercivity distributions for most of the chondrules is 〈10 mT, low-coercivity magnetic overprints are common. Therefore paleointensities based on the REM method, which rely on ratios of the natural remanent magnetization (NRM) to the saturation isothermal remanent magnetization (IRM) without magnetic cleaning, will probably be biased. The paleointensity bias is found to be about an order of magnitude for most chondrules with low-coercivity overprints. Paleointensity estimates based on a method we call REMc, which uses NRM/IRM ratios after magnetic cleaning, avoid this overprinting bias. Allende chondrules, which are the most pristine and possibly record the paleofield of the early solar system, have a mean REMc paleointensity of 10.4 μT. Karoonda and Bjurbole chondrules, which have experienced some thermal alteration, have REMc paleointensities of 4.6 and 3.2 μT, respectively.
    Description: NSF and INGV
    Description: Published
    Description: B03S90
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: reserved
    Keywords: paleomagnetism coercivity ; paleointensity ; magnetic interactions ; meteorite ; Chondrules ; FORC diagrams ; 01. Atmosphere::01.03. Magnetosphere::01.03.01. Interplanetary physics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 6
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    Radiocarbon and luminescence dating of overbank deposits in outwash sediments of the last glacial maximum in North Westland, New Zealand. (2003)
    In:  EPIC3New zealand journal of geology and geophysics, 46(1), pp. 95-106
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 7
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    Global birdsong embeddings enable superior transfer learning for bioacoustic classification (2023)
    In:  Scientific Reports vol. 13 no. 22876
    Details
    Publication Date: 2024-01-20
    Description: Automated bioacoustic analysis aids understanding and protection of both marine and terrestrial \nanimals and their habitats across extensive spatiotemporal scales, and typically involves analyzing \nvast collections of acoustic data. With the advent of deep learning models, classifcation of important \nsignals from these datasets has markedly improved. These models power critical data analyses for \nresearch and decision-making in biodiversity monitoring, animal behaviour studies, and natural \nresource management. However, deep learning models are often data-hungry and require a signifcant \namount of labeled training data to perform well. While sufcient training data is available for certain \ntaxonomic groups (e.g., common bird species), many classes (such as rare and endangered species, \nmany non-bird taxa, and call-type) lack enough data to train a robust model from scratch. This study \ninvestigates the utility of feature embeddings extracted from audio classifcation models to identify \nbioacoustic classes other than the ones these models were originally trained on. We evaluate models \non diverse datasets, including diferent bird calls and dialect types, bat calls, marine mammals calls, \nand amphibians calls. The embeddings extracted from the models trained on bird vocalization data \nconsistently allowed higher quality classifcation than the embeddings trained on general audio \ndatasets. The results of this study indicate that high-quality feature embeddings from large-scale \nacoustic bird classifers can be harnessed for few-shot transfer learning, enabling the learning of new \nclasses from a limited quantity of training data. Our fndings reveal the potential for efcient analyses \nof novel bioacoustic tasks, even in scenarios where available training data is limited to a few samples.
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Infrared Spectrometric Method for Monitoring Gaseous Organic Substances in Atmosphere (1956)
    s.l. : American Chemical Society
    Analytical chemistry 28 (1956), S. 945-949 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60114a005
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Electrical effects of a single stacking fault on fully depleted thin-film silicon-on-insulator P-channel metal–oxide–semiconductor field-effect transistors (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 420-426 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Electrical effects of a single stacking fault on fully depleted thin-film silicon-on-insulator (SOI) metal–oxide–semiconductor field-effect transistors (MOSFETs) were characterized. A simple method was demonstrated for the fabrication of fully depleted thin-film SOI MOSFETs with a single stacking fault in their channel region. SOI islands were created using selective epitaxial growth/epitaxial lateral overgrowth technology. The influence of a single stacking fault on device I–V characteristics was determined and compared to that of nearby identical devices without stacking faults. Off-state leakage currents, a threshold voltage shift, and drive current lowering were observed for devices with a single stacking fault in their channel region. Based on the location of the single stacking fault relative to the device channel region, various physical models were proposed to explain the phenomena observed. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1417995
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  • 10
    Electronic Resource
    Electronic Resource
    Write-Down Timeliness, Line-of-Business Disclosures and Investors’ Interpretations of Segment Divestiture Announcements (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of business finance & accounting 31 (2004), S. 0 
    Details
    ISSN: 1468-5957
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Abstract:  This paper examines investors’ anticipation and subsequent interpretations of asset write-downs accompanying segment divestitures. Examining long-window returns cumulated over the two years preceding the year of divestiture, we hypothesize and find that investors anticipate write-downs of segment operating assets before divestiture and recognition occurs, with anticipation conditional on the timeliness of the write-down and prior disclosure of the segments’ operating results under segment reporting rules. Short-window returns cumulated over the three days surrounding the announcement of the divestiture confirm that investor interpretations of asset write-downs are similarly contingent on write-down timeliness and prior disclosure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0306-686X.2004.00574.x
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