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  • 1
    Publikationsdatum: 2008-11-29
    Beschreibung: In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic information. Crosses between Drosophila strains that differ in the presence of a particular transposon can produce sterile progeny, a phenomenon called hybrid dysgenesis. This phenotype manifests itself only if the transposon is paternally inherited, suggesting maternal transmission of a factor that maintains fertility. In both P- and I-element-mediated hybrid dysgenesis models, daughters show a markedly different content of Piwi-interacting RNAs (piRNAs) targeting each element, depending on their parents of origin. Such differences persist from fertilization through adulthood. This indicates that maternally deposited piRNAs are important for mounting an effective silencing response and that a lack of maternal piRNA inheritance underlies hybrid dysgenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805124/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805124/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brennecke, Julius -- Malone, Colin D -- Aravin, Alexei A -- Sachidanandam, Ravi -- Stark, Alexander -- Hannon, Gregory J -- P01 CA013106/CA/NCI NIH HHS/ -- P01 CA013106-37/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 28;322(5906):1387-92. doi: 10.1126/science.1165171.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory (CSHL), 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19039138" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Argonaute Proteins ; Crosses, Genetic ; *DNA Transposable Elements ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/embryology/*genetics/physiology ; *Epigenesis, Genetic ; Female ; Fertility ; Hybridization, Genetic ; Male ; Ovary/metabolism ; Peptide Initiation Factors/genetics/metabolism ; *RNA Interference ; RNA, Small Interfering/*genetics/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2008-06-28
    Beschreibung: The atmospheric Cherenkov gamma-ray telescope MAGIC, designed for a low-energy threshold, has detected very-high-energy gamma rays from a giant flare of the distant Quasi-Stellar Radio Source (in short: radio quasar) 3C 279, at a distance of more than 5 billion light-years (a redshift of 0.536). No quasar has been observed previously in very-high-energy gamma radiation, and this is also the most distant object detected emitting gamma rays above 50 gigaelectron volts. Because high-energy gamma rays may be stopped by interacting with the diffuse background light in the universe, the observations by MAGIC imply a low amount for such light, consistent with that known from galaxy counts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MAGIC Collaboration -- Albert, J -- Aliu, E -- Anderhub, H -- Antonelli, L A -- Antoranz, P -- Backes, M -- Baixeras, C -- Barrio, J A -- Bartko, H -- Bastieri, D -- Becker, J K -- Bednarek, W -- Berger, K -- Bernardini, E -- Bigongiari, C -- Biland, A -- Bock, R K -- Bonnoli, G -- Bordas, P -- Bosch-Ramon, V -- Bretz, T -- Britvitch, I -- Camara, M -- Carmona, E -- Chilingarian, A -- Commichau, S -- Contreras, J L -- Cortina, J -- Costado, M T -- Covino, S -- Curtef, V -- Dazzi, F -- De Angelis, A -- De Cea Del Pozo, E -- de Los Reyes, R -- De Lotto, B -- De Maria, M -- De Sabata, F -- Mendez, C Delgado -- Dominguez, A -- Dorner, D -- Doro, M -- Errando, M -- Fagiolini, M -- Ferenc, D -- Fernandez, E -- Firpo, R -- Fonseca, M V -- Font, L -- Galante, N -- Lopez, R J Garcia -- Garczarczyk, M -- Gaug, M -- Goebel, F -- Hayashida, M -- Herrero, A -- Hohne, D -- Hose, J -- Hsu, C C -- Huber, S -- Jogler, T -- Kneiske, T M -- Kranich, D -- La Barbera, A -- Laille, A -- Leonardo, E -- Lindfors, E -- Lombardi, S -- Longo, F -- Lopez, M -- Lorenz, E -- Majumdar, P -- Maneva, G -- Mankuzhiyil, N -- Mannheim, K -- Maraschi, L -- Mariotti, M -- Martinez, M -- Mazin, D -- Meucci, M -- Meyer, M -- Miranda, J M -- Mirzoyan, R -- Mizobuchi, S -- Moles, M -- Moralejo, A -- Nieto, D -- Nilsson, K -- Ninkovic, J -- Otte, N -- Oya, I -- Panniello, M -- Paoletti, R -- Paredes, J M -- Pasanen, M -- Pascoli, D -- Pauss, F -- Pegna, R G -- Perez-Torres, M A -- Persic, M -- Peruzzo, L -- Piccioli, A -- Prada, F -- Prandini, E -- Puchades, N -- Raymers, A -- Rhode, W -- Ribo, M -- Rico, J -- Rissi, M -- Robert, A -- Rugamer, S -- Saggion, A -- Saito, T Y -- Salvati, M -- Sanchez-Conde, M -- Sartori, P -- Satalecka, K -- Scalzotto, V -- Scapin, V -- Schmitt, R -- Schweizer, T -- Shayduk, M -- Shinozaki, K -- Shore, S N -- Sidro, N -- Sierpowska-Bartosik, A -- Sillanpaa, A -- Sobczynska, D -- Spanier, F -- Stamerra, A -- Stark, L S -- Takalo, L -- Tavecchio, F -- Temnikov, P -- Tescaro, D -- Teshima, M -- Tluczykont, M -- Torres, D F -- Turini, N -- Vankov, H -- Venturini, A -- Vitale, V -- Wagner, R M -- Wittek, W -- Zabalza, V -- Zandanel, F -- Zanin, R -- Zapatero, J -- New York, N.Y. -- Science. 2008 Jun 27;320(5884):1752-4. doi: 10.1126/science.1157087.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universitat Wurzburg, D-97074 Wurzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18583607" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2008-10-18
    Beschreibung: One fundamental question about pulsars concerns the mechanism of their pulsed electromagnetic emission. Measuring the high-end region of a pulsar's spectrum would shed light on this question. By developing a new electronic trigger, we lowered the threshold of the Major Atmospheric gamma-ray Imaging Cherenkov (MAGIC) telescope to 25 giga-electron volts. In this configuration, we detected pulsed gamma-rays from the Crab pulsar that were greater than 25 giga-electron volts, revealing a relatively high cutoff energy in the phase-averaged spectrum. This indicates that the emission occurs far out in the magnetosphere, hence excluding the polar-cap scenario as a possible explanation of our measurement. The high cutoff energy also challenges the slot-gap scenario.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MAGIC Collaboration -- Aliu, E -- Anderhub, H -- Antonelli, L A -- Antoranz, P -- Backes, M -- Baixeras, C -- Barrio, J A -- Bartko, H -- Bastieri, D -- Becker, J K -- Bednarek, W -- Berger, K -- Bernardini, E -- Bigongiari, C -- Biland, A -- Bock, R K -- Bonnoli, G -- Bordas, P -- Bosch-Ramon, V -- Bretz, T -- Britvitch, I -- Camara, M -- Carmona, E -- Chilingarian, A -- Commichau, S -- Contreras, J L -- Cortina, J -- Costado, M T -- Covino, S -- Curtef, V -- Dazzi, F -- De Angelis, A -- De Cea Del Pozo, E -- de Los Reyes, R -- De Lotto, B -- De Maria, M -- De Sabata, F -- Delgado Mendez, C -- Dominguez, A -- Dorner, D -- Doro, M -- Elsasser, D -- Errando, M -- Fagiolini, M -- Ferenc, D -- Fernandez, E -- Firpo, R -- Fonseca, M V -- Font, L -- Galante, N -- Garcia Lopez, R J -- Garczarczyk, M -- Gaug, M -- Goebel, F -- Hadasch, D -- Hayashida, M -- Herrero, A -- Hohne, D -- Hose, J -- Hsu, C C -- Huber, S -- Jogler, T -- Kranich, D -- La Barbera, A -- Laille, A -- Leonardo, E -- Lindfors, E -- Lombardi, S -- Longo, F -- Lopez, M -- Lorenz, E -- Majumdar, P -- Maneva, G -- Mankuzhiyil, N -- Mannheim, K -- Maraschi, L -- Mariotti, M -- Martinez, M -- Mazin, D -- Meucci, M -- Meyer, M -- Miranda, J M -- Mirzoyan, R -- Moles, M -- Moralejo, A -- Nieto, D -- Nilsson, K -- Ninkovic, J -- Otte, N -- Oya, I -- Paoletti, R -- Paredes, J M -- Pasanen, M -- Pascoli, D -- Pauss, F -- Pegna, R G -- Perez-Torres, M A -- Persic, M -- Peruzzo, L -- Piccioli, A -- Prada, F -- Prandini, E -- Puchades, N -- Raymers, A -- Rhode, W -- Ribo, M -- Rico, J -- Rissi, M -- Robert, A -- Rugamer, S -- Saggion, A -- Saito, T Y -- Salvati, M -- Sanchez-Conde, M -- Sartori, P -- Satalecka, K -- Scalzotto, V -- Scapin, V -- Schweizer, T -- Shayduk, M -- Shinozaki, K -- Shore, S N -- Sidro, N -- Sierpowska-Bartosik, A -- Sillanpaa, A -- Sobczynska, D -- Spanier, F -- Stamerra, A -- Stark, L S -- Takalo, L -- Tavecchio, F -- Temnikov, P -- Tescaro, D -- Teshima, M -- Tluczykont, M -- Torres, D F -- Turini, N -- Vankov, H -- Venturini, A -- Vitale, V -- Wagner, R M -- Wittek, W -- Zabalza, V -- Zandanel, F -- Zanin, R -- Zapatero, J -- de Jager, O C -- de Ona Wilhelmi, E -- New York, N.Y. -- Science. 2008 Nov 21;322(5905):1221-4. doi: 10.1126/science.1164718. Epub 2008 Oct 16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18927358" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2008-03-22
    Beschreibung: Pattern separation, the process of transforming similar representations or memories into highly dissimilar, nonoverlapping representations, is a key component of many functions ascribed to the hippocampus. Computational models have stressed the role of the hippocampus and, in particular, the dentate gyrus and its projections into the CA3 subregion in pattern separation. We used high-resolution (1.5-millimeter isotropic voxels) functional magnetic resonance imaging to measure brain activity during incidental memory encoding. Although activity consistent with a bias toward pattern completion was observed in CA1, the subiculum, and the entorhinal and parahippocampal cortices, activity consistent with a strong bias toward pattern separation was observed in, and limited to, the CA3/dentate gyrus. These results provide compelling evidence of a key role of the human CA3/dentate gyrus in pattern separation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829853/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829853/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bakker, Arnold -- Kirwan, C Brock -- Miller, Michael -- Stark, Craig E L -- P41 RR15241-01A1/RR/NCRR NIH HHS/ -- R01 EB000975/EB/NIBIB NIH HHS/ -- R01 EB000975-04/EB/NIBIB NIH HHS/ -- R01 EB008171/EB/NIBIB NIH HHS/ -- R01 EB008171-01A1/EB/NIBIB NIH HHS/ -- R01 EB00975-01/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 21;319(5870):1640-2. doi: 10.1126/science.1152882.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18356518" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Analysis of Variance ; Brain Mapping ; Dentate Gyrus/*physiology ; Entorhinal Cortex/physiology ; Female ; Hippocampus/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory/*physiology ; Parahippocampal Gyrus/physiology ; *Pattern Recognition, Physiological
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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