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  • 1
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    Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999
    Beschreibung: Stable delivery of a therapeutic protein under pharmacologic control was achieved through in vivo somatic gene transfer. This system was based on the expression of two chimeric, human-derived proteins that were reconstituted by rapamycin into a transcription factor complex. A mixture of two adeno-associated virus vectors, one expressing the transcription factor chimeras and one containing erythropoietin (Epo) under the control of a promoter responsive to the transcription factor, was injected into skeletal muscle of immune-competent mice. Administration of rapamycin resulted in 200-fold induction of plasma Epo. Stable engraftment of this humanized system in immune-competent mice was achieved for 6 months with similar results for at least 3 months in a rhesus monkey.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ye, X -- Rivera, V M -- Zoltick, P -- Cerasoli, F Jr -- Schnell, M A -- Gao, G -- Hughes, J V -- Gilman, M -- Wilson, J M -- P01 AR/NS43648-03/AR/NIAMS NIH HHS/ -- P30 DK47757-05/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 1;283(5398):88-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9872748" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cytomegalovirus/genetics ; Dependovirus/genetics ; Erythropoietin/administration & dosage/blood/*genetics ; Female ; Gene Expression Regulation ; *Gene Transfer Techniques ; Genetic Therapy/*methods ; Genetic Vectors ; Hematocrit ; Injections, Intramuscular ; Macaca mulatta ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Muscle, Skeletal ; Promoter Regions, Genetic ; Recombinant Fusion Proteins ; Recombinant Proteins ; Sirolimus/*pharmacology ; Transcription Factors/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    ASCA Observations of LMC SNRS (1999)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: We present our first results from a study of the supernova remnants (SNRs) in the Large Magellanic Cloud (LMC) using data from ASCA. The three remnants we have analyzed to date, 0509-67.5, 0519-69.0, and N103B, are among the smallest, and presumably also the youngest, in the Cloud. The X-ray spectra of these SNRs show strong K(alpha) emission lines of silicon, sulfur, argon, and calcium with no evidence for corresponding lines of oxygen, neon, or magnesium. The dominant feature in the spectra is a broad blend of emission lines around 1 keV which we attribute to L-shell emission lines of iron. Model calculations (Nomoto, Thielemann, & Yokoi 1984) show that the major products of nucleosynthesis in Type Ia supernovae (SNs) are the elements from silicon to iron, as observed here. The calculated nucleosynthetic yields from Type Ib and II SNs are shown to be qualitatively inconsistent with the data. We conclude that the SNs which produced these remnants were of Type Ia. This finding also confirms earlier suggestions that the class of Balmer-dominated remnants arise from Type Ia SN explosions. Based an these early results from the LMC SNR sample, we find that roughly one-half of the SNRs produced in the LMC within the last approximately 1500 yr came from Type Ia SNs.
    Schlagwort(e): Astronomy
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    ROSAT PSPC and HRI Observations of Supernova Remnant G292.0+1.8 (1999)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: The supernova remnant G292.0+1.8 was observed by the ROSAT PSPC for 18 ksec as part of this grant. Considerable effort was put into the analysis of the PSPC spectra. The major work went into nonequilibrium ionization joint spectral fits with the Einstein SSS and EXOSAT ME data which indicated that the two spatial regions of this remnant (a central bar and a plateau region covering a larger extent) had similar abundances, but different excitation conditions (temperature and ionization state), an important conclusion, if true. Unfortunately as this work was being finished, new ASCA data revealed the presence of a previously unknown, spectrally hard X-ray source near the center of the remnant which contaminated the SSS and ME data and as a consequence made our detailed spectral analysis done up until then un-publishable. We searched for evidence of this hard source in the PSPC data both spectrally and using timing searches (for a pulsar), but found nothing significant. ROSAT HRI data were also obtained on this remnant. These data were compared to the Einstein HRI data to search for evidence of spectral variations with position and possible expansion of the X-ray remnant. One feature in the remnant appears to have changed in brightness although it is not clear what is the cause of the change. No evidence for the hard ASCA source was apparent in the HRI data.
    Schlagwort(e): Astronomy
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    ASCA Observations of W44 (1999)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: We report the detection, using data from the Advanced Satellite for Cosmology and Astrophysics (ASCA), of a hard X-ray source in the vicinity of the radio pulsar PSR B1853+01, which is located within the supernova remnant (SNR) W44. PSR B1853+01, a 267 ms pulsar, has to date been detected only in the radio band. Previous observations at soft X-ray energies (e.g., with ROSAT HRI) have failed to detect any significant X-ray emission (pulsed or unpulsed) from the pulsar. In addition, no high-energy emission (approx. 〉 4 keV) has been detected previously from W44. Over the 0.5-4.0 keV band, the ASCA data show soft thermal emission from W44, with a morphology very similar to that observed earlier by Einstein and ROSAT. In the high-energy band (4.0-9.5 keV), the SNR is, for the most part, invisible, although a source coincident with the position of PSR B1853+01 is evident. The observed ASCA spectra are consistent with a power-law origin (photon index approx. 2.3) for the X-ray emission from this source at a flux level (flux density approx. 0.5 micro Jy at I keV) consistent with previous upper limits. The maximum allowed size for the source is determined directiv from the ASCA data (〈5 min.), while the minimum size is derived from the nondetection of a point source in the ROSAT HRI data (approx. 〉 30 sec.). Timing analysis of the hard X-ray source failed to detect pulsations at the pulsar's period. Based on these lines of evidence, we conclude that the new hard source in W44 represents an X-ray synchrotron nebula associated with PSR B1853+01, rather than the beamed output of the pulsar itself. This discoverv adds W44 to the small group of previously known plerionic SNRs This nebula lies at the low end of, but is consistent with, the correlation between X-ray luminosity and pulsar spin-down energy loss found for such objects, lending further support to our interpretation.
    Schlagwort(e): Astronomy
    Materialart: Contrib-595
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    ROSAT PSPC Observations of CL0016+16 (1999)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: NASA Grant NAG5-2156 has supported the analysis of several ROSAT observations, which have resulted in the publications. Contents include the following: 1. X-ray Observations of the Sunyaev-Zeldovich Decrement Clusters Abell 665 and CLOO16+16. 2. Complex Spatial Structures in Sunyaev-Zeldovich Decrement Clusters Abell 665 and CLOO16+16. 3. Discovery of Be/X-ray Stars in Two Supernova Remnants in the Small magellanic Cloud. 4. A New Transient Pulsar in the Small Magellanic Cloud with an Unusual X-ray Spectrum. 5. A New X-ray-Discovered Cluster of Galaxies Associated A,ith CLOO16+16. 6. A new X-ray-Discovered Cluster of Galaxies Associated with C10016+16. 7. The Distance to CLOO16+16 and the Hubble Constant. 8. HST Observations of Oxygen-rich Supernova Remnants in the Magellanic Clouds. I. Narrow-band Imaging of N132D in the LMC. 9. The Expansion of the X-ray Remnant of Tycho's Supernova (SN1572). 10. Supernova Remnants Associated with Molecular Clouds in the Large Magellanic Cloud. 11. A Measurement of the Hubble Constant from the X-ray Properties and the Sunyaev-Zeldovich Effect of CLOO16+16.
    Schlagwort(e): Astronomy
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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